Influence of surface morphology of chitosan films modified by chitin nanofibrils on their biological properties
•Chitosan-chitin composite film are characterized by their oriented structure.•Chitosan macromolecules self-organize on the chitin nanofibrils surface.•Chitin nanofibrils enhances mechanical properties, specific conductivity, proliferative activity of fibroblasts on the composite surface.•Optimal co...
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| Veröffentlicht in: | Carbohydrate polymers 2021-06, Vol.262, p.117917-117917, Article 117917 |
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| creator | Dresvyanina, E.N. Kodolova-Chukhontseva, V.V. Bystrov, S.G. Dobrovolskaya, I.P. Vaganov, G.V. Smirnova, N.V. Kolbe, K.A. Kamalov, A.M. Ivan’kova, E.M. Morganti, P. Yudin, V.E. |
| description | •Chitosan-chitin composite film are characterized by their oriented structure.•Chitosan macromolecules self-organize on the chitin nanofibrils surface.•Chitin nanofibrils enhances mechanical properties, specific conductivity, proliferative activity of fibroblasts on the composite surface.•Optimal concentration of chitin nanofibrils in the composite film is 5 wt.%.
The paper is devoted to the study of influence of chitin nanofibrils on the structure, surface morphology, mechanical properties, and electrical conductivity of chitosan-based composite films intended for use in biomedical technologies. It was demonstrated that the optimal concentration of chitin nanofibrils in the composite film is 5 wt.%. For the films of this composition, we observed orientation of structural elements on film surface, enhanced mechanical properties as well as an increase in both specific conductivity and proliferative activity of skin fibroblasts on film surface. These results are related to the appearance of oriented structure in nanocomposites and to self-organization of chitosan macromolecules on the surface of chitin nanofibrils. It was revealed that increase in surface energy and surface hydrophilicity did not facilitate effective adhesion, viability and proliferative activity of cells during cultivation on the surface of composite films. |
| doi_str_mv | 10.1016/j.carbpol.2021.117917 |
| format | Article |
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The paper is devoted to the study of influence of chitin nanofibrils on the structure, surface morphology, mechanical properties, and electrical conductivity of chitosan-based composite films intended for use in biomedical technologies. It was demonstrated that the optimal concentration of chitin nanofibrils in the composite film is 5 wt.%. For the films of this composition, we observed orientation of structural elements on film surface, enhanced mechanical properties as well as an increase in both specific conductivity and proliferative activity of skin fibroblasts on film surface. These results are related to the appearance of oriented structure in nanocomposites and to self-organization of chitosan macromolecules on the surface of chitin nanofibrils. It was revealed that increase in surface energy and surface hydrophilicity did not facilitate effective adhesion, viability and proliferative activity of cells during cultivation on the surface of composite films.</description><identifier>ISSN: 0144-8617</identifier><identifier>EISSN: 1879-1344</identifier><identifier>DOI: 10.1016/j.carbpol.2021.117917</identifier><identifier>PMID: 33838798</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Chitin nanofibrils ; Chitosan ; Hydrophobicity ; Mechanical properties ; Proliferative activity of cells ; Surface morphology</subject><ispartof>Carbohydrate polymers, 2021-06, Vol.262, p.117917-117917, Article 117917</ispartof><rights>2021 Elsevier Ltd</rights><rights>Copyright © 2021 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-c1ce0692efeedc6253fec8d58a0b6a0f60af750cd13697409f24e995a3e93ef63</citedby><cites>FETCH-LOGICAL-c365t-c1ce0692efeedc6253fec8d58a0b6a0f60af750cd13697409f24e995a3e93ef63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0144861721003040$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33838798$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dresvyanina, E.N.</creatorcontrib><creatorcontrib>Kodolova-Chukhontseva, V.V.</creatorcontrib><creatorcontrib>Bystrov, S.G.</creatorcontrib><creatorcontrib>Dobrovolskaya, I.P.</creatorcontrib><creatorcontrib>Vaganov, G.V.</creatorcontrib><creatorcontrib>Smirnova, N.V.</creatorcontrib><creatorcontrib>Kolbe, K.A.</creatorcontrib><creatorcontrib>Kamalov, A.M.</creatorcontrib><creatorcontrib>Ivan’kova, E.M.</creatorcontrib><creatorcontrib>Morganti, P.</creatorcontrib><creatorcontrib>Yudin, V.E.</creatorcontrib><title>Influence of surface morphology of chitosan films modified by chitin nanofibrils on their biological properties</title><title>Carbohydrate polymers</title><addtitle>Carbohydr Polym</addtitle><description>•Chitosan-chitin composite film are characterized by their oriented structure.•Chitosan macromolecules self-organize on the chitin nanofibrils surface.•Chitin nanofibrils enhances mechanical properties, specific conductivity, proliferative activity of fibroblasts on the composite surface.•Optimal concentration of chitin nanofibrils in the composite film is 5 wt.%.
The paper is devoted to the study of influence of chitin nanofibrils on the structure, surface morphology, mechanical properties, and electrical conductivity of chitosan-based composite films intended for use in biomedical technologies. It was demonstrated that the optimal concentration of chitin nanofibrils in the composite film is 5 wt.%. For the films of this composition, we observed orientation of structural elements on film surface, enhanced mechanical properties as well as an increase in both specific conductivity and proliferative activity of skin fibroblasts on film surface. These results are related to the appearance of oriented structure in nanocomposites and to self-organization of chitosan macromolecules on the surface of chitin nanofibrils. It was revealed that increase in surface energy and surface hydrophilicity did not facilitate effective adhesion, viability and proliferative activity of cells during cultivation on the surface of composite films.</description><subject>Chitin nanofibrils</subject><subject>Chitosan</subject><subject>Hydrophobicity</subject><subject>Mechanical properties</subject><subject>Proliferative activity of cells</subject><subject>Surface morphology</subject><issn>0144-8617</issn><issn>1879-1344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqFkE1v3CAQhlGVqtl8_IRWHHPxljE2NqcqitI20kq9pGeE8dBlhY0LdqT998HZba_hApp5Zl7xEPIZ2BYYiK-HrdGxm4LflqyELUAjoflANtA2sgBeVRdkw6CqilZAc0muUjqwfASwT-SS85Znrt2Q8DRav-BokAZL0xKtzs8hxGkffPhzXKtm7-aQ9Eit80PKzd5Zhz3tjm8tN9JRj8G6LjqfaBjpvEcXaefWDc5oT6cYJoyzw3RDPlrtE96e72vy-_vj88PPYvfrx9PD_a4wXNRzYcAgE7JEi9gbUdbcomn7utWsE5pZwbRtamZ64EI2FZO2rFDKWnOUHK3g1-TutDdH_10wzWpwyaD3esSwJFXWAK2sBeMZrU-oiSGliFZN0Q06HhUwtbpWB3V2rVbX6uQ6z305RyzdgP3_qX9yM_DtBGD-6IvDqJJxq-reRTSz6oN7J-IVza-VQQ</recordid><startdate>20210615</startdate><enddate>20210615</enddate><creator>Dresvyanina, E.N.</creator><creator>Kodolova-Chukhontseva, V.V.</creator><creator>Bystrov, S.G.</creator><creator>Dobrovolskaya, I.P.</creator><creator>Vaganov, G.V.</creator><creator>Smirnova, N.V.</creator><creator>Kolbe, K.A.</creator><creator>Kamalov, A.M.</creator><creator>Ivan’kova, E.M.</creator><creator>Morganti, P.</creator><creator>Yudin, V.E.</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20210615</creationdate><title>Influence of surface morphology of chitosan films modified by chitin nanofibrils on their biological properties</title><author>Dresvyanina, E.N. ; Kodolova-Chukhontseva, V.V. ; Bystrov, S.G. ; Dobrovolskaya, I.P. ; Vaganov, G.V. ; Smirnova, N.V. ; Kolbe, K.A. ; Kamalov, A.M. ; Ivan’kova, E.M. ; Morganti, P. ; Yudin, V.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-c1ce0692efeedc6253fec8d58a0b6a0f60af750cd13697409f24e995a3e93ef63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Chitin nanofibrils</topic><topic>Chitosan</topic><topic>Hydrophobicity</topic><topic>Mechanical properties</topic><topic>Proliferative activity of cells</topic><topic>Surface morphology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dresvyanina, E.N.</creatorcontrib><creatorcontrib>Kodolova-Chukhontseva, V.V.</creatorcontrib><creatorcontrib>Bystrov, S.G.</creatorcontrib><creatorcontrib>Dobrovolskaya, I.P.</creatorcontrib><creatorcontrib>Vaganov, G.V.</creatorcontrib><creatorcontrib>Smirnova, N.V.</creatorcontrib><creatorcontrib>Kolbe, K.A.</creatorcontrib><creatorcontrib>Kamalov, A.M.</creatorcontrib><creatorcontrib>Ivan’kova, E.M.</creatorcontrib><creatorcontrib>Morganti, P.</creatorcontrib><creatorcontrib>Yudin, V.E.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Carbohydrate polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dresvyanina, E.N.</au><au>Kodolova-Chukhontseva, V.V.</au><au>Bystrov, S.G.</au><au>Dobrovolskaya, I.P.</au><au>Vaganov, G.V.</au><au>Smirnova, N.V.</au><au>Kolbe, K.A.</au><au>Kamalov, A.M.</au><au>Ivan’kova, E.M.</au><au>Morganti, P.</au><au>Yudin, V.E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of surface morphology of chitosan films modified by chitin nanofibrils on their biological properties</atitle><jtitle>Carbohydrate polymers</jtitle><addtitle>Carbohydr Polym</addtitle><date>2021-06-15</date><risdate>2021</risdate><volume>262</volume><spage>117917</spage><epage>117917</epage><pages>117917-117917</pages><artnum>117917</artnum><issn>0144-8617</issn><eissn>1879-1344</eissn><abstract>•Chitosan-chitin composite film are characterized by their oriented structure.•Chitosan macromolecules self-organize on the chitin nanofibrils surface.•Chitin nanofibrils enhances mechanical properties, specific conductivity, proliferative activity of fibroblasts on the composite surface.•Optimal concentration of chitin nanofibrils in the composite film is 5 wt.%.
The paper is devoted to the study of influence of chitin nanofibrils on the structure, surface morphology, mechanical properties, and electrical conductivity of chitosan-based composite films intended for use in biomedical technologies. It was demonstrated that the optimal concentration of chitin nanofibrils in the composite film is 5 wt.%. For the films of this composition, we observed orientation of structural elements on film surface, enhanced mechanical properties as well as an increase in both specific conductivity and proliferative activity of skin fibroblasts on film surface. These results are related to the appearance of oriented structure in nanocomposites and to self-organization of chitosan macromolecules on the surface of chitin nanofibrils. It was revealed that increase in surface energy and surface hydrophilicity did not facilitate effective adhesion, viability and proliferative activity of cells during cultivation on the surface of composite films.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>33838798</pmid><doi>10.1016/j.carbpol.2021.117917</doi><tpages>1</tpages></addata></record> |
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| subjects | Chitin nanofibrils Chitosan Hydrophobicity Mechanical properties Proliferative activity of cells Surface morphology |
| title | Influence of surface morphology of chitosan films modified by chitin nanofibrils on their biological properties |
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