A fatal wound complication following sequential anti-angiogenesis, immune checkpoint inhibition and ultra-hypofractionated radiotherapy
Purpose Multimodality treatments combining radiotherapy, immune therapy and/or targeted therapy are under heavy investigation. Promising data from clinical trials are emerging, nevertheless unexpected interactions and adverse events should not be overlooked. Case presentation Here we present a case...
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| Veröffentlicht in: | Clinical journal of gastroenterology 2021-08, Vol.14 (4), p.1121-1125 |
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| container_issue | 4 |
| container_start_page | 1121 |
| container_title | Clinical journal of gastroenterology |
| container_volume | 14 |
| creator | Orazem, Miha Draulans, Cédric Spaas, Mathieu Van Cutsem, Eric Debecker, Marina De Meerleer, Gert Tejpar, Sabine Dekervel, Jeroen Haustermans, Karin |
| description | Purpose
Multimodality treatments combining radiotherapy, immune therapy and/or targeted therapy are under heavy investigation. Promising data from clinical trials are emerging, nevertheless unexpected interactions and adverse events should not be overlooked.
Case presentation
Here we present a case study of a patient with metastatic colon adenocarcinoma treated sequentially with a chemotherapy/targeted therapy combination, immune checkpoint inhibitors and ultra-hypofractionated radiotherapy. After radiation treatment, the patient developed extensive posterior abdominal wall wounds coinciding with regression of the irradiated metastatic tumour mass and marked elevation of the inflammation parameters.
Conclusion
This case represents an unusual fatal wound complication after palliative ultra-hypofractionated radiotherapy. Further research into synergistic effects of sequential radiotherapy and anti-angiogenesis therapy may provide an advantage in anticipating severe sequelae. |
| doi_str_mv | 10.1007/s12328-021-01399-2 |
| format | Article |
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Multimodality treatments combining radiotherapy, immune therapy and/or targeted therapy are under heavy investigation. Promising data from clinical trials are emerging, nevertheless unexpected interactions and adverse events should not be overlooked.
Case presentation
Here we present a case study of a patient with metastatic colon adenocarcinoma treated sequentially with a chemotherapy/targeted therapy combination, immune checkpoint inhibitors and ultra-hypofractionated radiotherapy. After radiation treatment, the patient developed extensive posterior abdominal wall wounds coinciding with regression of the irradiated metastatic tumour mass and marked elevation of the inflammation parameters.
Conclusion
This case represents an unusual fatal wound complication after palliative ultra-hypofractionated radiotherapy. Further research into synergistic effects of sequential radiotherapy and anti-angiogenesis therapy may provide an advantage in anticipating severe sequelae.</description><identifier>ISSN: 1865-7257</identifier><identifier>EISSN: 1865-7265</identifier><identifier>DOI: 10.1007/s12328-021-01399-2</identifier><identifier>PMID: 33844128</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Abdominal Surgery ; Case Report ; Colorectal Surgery ; Combined Modality Therapy ; Gastroenterology ; Hepatology ; Humans ; Immune Checkpoint Inhibitors ; Immunotherapy ; Medicine ; Medicine & Public Health ; Surgical Oncology</subject><ispartof>Clinical journal of gastroenterology, 2021-08, Vol.14 (4), p.1121-1125</ispartof><rights>Japanese Society of Gastroenterology 2021</rights><rights>2021. Japanese Society of Gastroenterology.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-fced3ee3ad16911b115d20e6df674e6bf04d21282b15ac897703c58797c40d893</citedby><cites>FETCH-LOGICAL-c415t-fced3ee3ad16911b115d20e6df674e6bf04d21282b15ac897703c58797c40d893</cites><orcidid>0000-0002-1267-7874</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12328-021-01399-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12328-021-01399-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33844128$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Orazem, Miha</creatorcontrib><creatorcontrib>Draulans, Cédric</creatorcontrib><creatorcontrib>Spaas, Mathieu</creatorcontrib><creatorcontrib>Van Cutsem, Eric</creatorcontrib><creatorcontrib>Debecker, Marina</creatorcontrib><creatorcontrib>De Meerleer, Gert</creatorcontrib><creatorcontrib>Tejpar, Sabine</creatorcontrib><creatorcontrib>Dekervel, Jeroen</creatorcontrib><creatorcontrib>Haustermans, Karin</creatorcontrib><title>A fatal wound complication following sequential anti-angiogenesis, immune checkpoint inhibition and ultra-hypofractionated radiotherapy</title><title>Clinical journal of gastroenterology</title><addtitle>Clin J Gastroenterol</addtitle><addtitle>Clin J Gastroenterol</addtitle><description>Purpose
Multimodality treatments combining radiotherapy, immune therapy and/or targeted therapy are under heavy investigation. Promising data from clinical trials are emerging, nevertheless unexpected interactions and adverse events should not be overlooked.
Case presentation
Here we present a case study of a patient with metastatic colon adenocarcinoma treated sequentially with a chemotherapy/targeted therapy combination, immune checkpoint inhibitors and ultra-hypofractionated radiotherapy. After radiation treatment, the patient developed extensive posterior abdominal wall wounds coinciding with regression of the irradiated metastatic tumour mass and marked elevation of the inflammation parameters.
Conclusion
This case represents an unusual fatal wound complication after palliative ultra-hypofractionated radiotherapy. Further research into synergistic effects of sequential radiotherapy and anti-angiogenesis therapy may provide an advantage in anticipating severe sequelae.</description><subject>Abdominal Surgery</subject><subject>Case Report</subject><subject>Colorectal Surgery</subject><subject>Combined Modality Therapy</subject><subject>Gastroenterology</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Immune Checkpoint Inhibitors</subject><subject>Immunotherapy</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Surgical Oncology</subject><issn>1865-7257</issn><issn>1865-7265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctu3CAUhlHVqLm0L9BFxLKL0nAxxl5GUZpEitRNu0YYjmdIbHAAK5on6GuXZCZZdnUQfOeTfn6EvjL6g1GqLjLjgneEckYoE31P-Ad0wrpWEsVb-fH9LNUxOs35gdKWUyU-oWMhuqZhvDtBfy_xaIqZ8HNcg8M2zsvkrSk-BjzGaYrPPmxwhqcVQvGVM3UQEzY-biBA9vk79vO8BsB2C_ZxiT4U7MPWD_5VYqp1nUoyZLtb4piMfbk2BRxOxvlYtpDMsvuMjkYzZfhymGfoz8_r31e35P7Xzd3V5T2xDZOFjBacABDGsbZnbGBMOk6hdWOrGmiHkTaO12B8YNLYrleKCis71SvbUNf14gx923uXFGumXPTss4VpMgHimjWXjHW9FD2tKN-jNsWcE4x6SX42aacZ1S8F6H0BuhagXwvQvC6dH_zrMIN7X3n78QqIPZDrU9hA0g9xTaFm_p_2H0UJlL4</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Orazem, Miha</creator><creator>Draulans, Cédric</creator><creator>Spaas, Mathieu</creator><creator>Van Cutsem, Eric</creator><creator>Debecker, Marina</creator><creator>De Meerleer, Gert</creator><creator>Tejpar, Sabine</creator><creator>Dekervel, Jeroen</creator><creator>Haustermans, Karin</creator><general>Springer Singapore</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1267-7874</orcidid></search><sort><creationdate>20210801</creationdate><title>A fatal wound complication following sequential anti-angiogenesis, immune checkpoint inhibition and ultra-hypofractionated radiotherapy</title><author>Orazem, Miha ; Draulans, Cédric ; Spaas, Mathieu ; Van Cutsem, Eric ; Debecker, Marina ; De Meerleer, Gert ; Tejpar, Sabine ; Dekervel, Jeroen ; Haustermans, Karin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-fced3ee3ad16911b115d20e6df674e6bf04d21282b15ac897703c58797c40d893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Abdominal Surgery</topic><topic>Case Report</topic><topic>Colorectal Surgery</topic><topic>Combined Modality Therapy</topic><topic>Gastroenterology</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Immune Checkpoint Inhibitors</topic><topic>Immunotherapy</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Surgical Oncology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Orazem, Miha</creatorcontrib><creatorcontrib>Draulans, Cédric</creatorcontrib><creatorcontrib>Spaas, Mathieu</creatorcontrib><creatorcontrib>Van Cutsem, Eric</creatorcontrib><creatorcontrib>Debecker, Marina</creatorcontrib><creatorcontrib>De Meerleer, Gert</creatorcontrib><creatorcontrib>Tejpar, Sabine</creatorcontrib><creatorcontrib>Dekervel, Jeroen</creatorcontrib><creatorcontrib>Haustermans, Karin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Orazem, Miha</au><au>Draulans, Cédric</au><au>Spaas, Mathieu</au><au>Van Cutsem, Eric</au><au>Debecker, Marina</au><au>De Meerleer, Gert</au><au>Tejpar, Sabine</au><au>Dekervel, Jeroen</au><au>Haustermans, Karin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A fatal wound complication following sequential anti-angiogenesis, immune checkpoint inhibition and ultra-hypofractionated radiotherapy</atitle><jtitle>Clinical journal of gastroenterology</jtitle><stitle>Clin J Gastroenterol</stitle><addtitle>Clin J Gastroenterol</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>14</volume><issue>4</issue><spage>1121</spage><epage>1125</epage><pages>1121-1125</pages><issn>1865-7257</issn><eissn>1865-7265</eissn><abstract>Purpose
Multimodality treatments combining radiotherapy, immune therapy and/or targeted therapy are under heavy investigation. Promising data from clinical trials are emerging, nevertheless unexpected interactions and adverse events should not be overlooked.
Case presentation
Here we present a case study of a patient with metastatic colon adenocarcinoma treated sequentially with a chemotherapy/targeted therapy combination, immune checkpoint inhibitors and ultra-hypofractionated radiotherapy. After radiation treatment, the patient developed extensive posterior abdominal wall wounds coinciding with regression of the irradiated metastatic tumour mass and marked elevation of the inflammation parameters.
Conclusion
This case represents an unusual fatal wound complication after palliative ultra-hypofractionated radiotherapy. Further research into synergistic effects of sequential radiotherapy and anti-angiogenesis therapy may provide an advantage in anticipating severe sequelae.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>33844128</pmid><doi>10.1007/s12328-021-01399-2</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-1267-7874</orcidid><oa>free_for_read</oa></addata></record> |
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| issn | 1865-7257 1865-7265 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Abdominal Surgery Case Report Colorectal Surgery Combined Modality Therapy Gastroenterology Hepatology Humans Immune Checkpoint Inhibitors Immunotherapy Medicine Medicine & Public Health Surgical Oncology |
| title | A fatal wound complication following sequential anti-angiogenesis, immune checkpoint inhibition and ultra-hypofractionated radiotherapy |
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