The positive effect of pregnancy in rheumatoid arthritis and the use of medications for the management of rheumatoid arthritis during pregnancy
Rheumatoid arthritis (RA) is an autoimmune systemic inflammatory disorder that is mostly characterised by progressive symmetrical joint destruction, particularly in the wrist and fingers, while it may also affect additional joints and several organs, such as the skin, heart, blood vessels, and lungs...
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| Veröffentlicht in: | Inflammopharmacology 2021-08, Vol.29 (4), p.987-1000 |
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| creator | Sharma, Uday Raj Nediyedath Rathnakaran, Akhila Raj, B. P. Prudhvi Padinjakkara, Gayathry Das, Akanksh Vada, Surendra Mudagal, Manjunatha P. |
| description | Rheumatoid arthritis (RA) is an autoimmune systemic inflammatory disorder that is mostly characterised by progressive symmetrical joint destruction, particularly in the wrist and fingers, while it may also affect additional joints and several organs, such as the skin, heart, blood vessels, and lungs. It is identified by raised anti-rheumatoid factor and anti-cyclic citrullinated peptide antibodies. The chemical mediators involved in the activity of RA are IL-1β, TNF-α, and IL-6. Pregnancy exerts a positive effect on RA that helps to modulate the disease condition. Different hypotheses are recommended to explain the ameliorating effect of pregnancy in RA. RA cannot be completely cured. The treatment goal is the attrition of pain and inflammation and the further progression of the disease. Long-term management of RA is carried out using disease-modifying antirheumatic drugs (DMARDs). Therapy of acute flares can be done with Non-steroidal anti-inflammatory drugs (NSAIDs) accompanied by ad interim usage of glucocorticoids. Biologic response modifiers are also available; they act by abolishing the activity of T- cells. However, it is necessary to select the correct treatment regimen when it comes to the management of RA in pregnancy. |
| doi_str_mv | 10.1007/s10787-021-00808-9 |
| format | Article |
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P. Prudhvi ; Padinjakkara, Gayathry ; Das, Akanksh ; Vada, Surendra ; Mudagal, Manjunatha P.</creator><creatorcontrib>Sharma, Uday Raj ; Nediyedath Rathnakaran, Akhila ; Raj, B. P. Prudhvi ; Padinjakkara, Gayathry ; Das, Akanksh ; Vada, Surendra ; Mudagal, Manjunatha P.</creatorcontrib><description>Rheumatoid arthritis (RA) is an autoimmune systemic inflammatory disorder that is mostly characterised by progressive symmetrical joint destruction, particularly in the wrist and fingers, while it may also affect additional joints and several organs, such as the skin, heart, blood vessels, and lungs. It is identified by raised anti-rheumatoid factor and anti-cyclic citrullinated peptide antibodies. The chemical mediators involved in the activity of RA are IL-1β, TNF-α, and IL-6. Pregnancy exerts a positive effect on RA that helps to modulate the disease condition. Different hypotheses are recommended to explain the ameliorating effect of pregnancy in RA. RA cannot be completely cured. The treatment goal is the attrition of pain and inflammation and the further progression of the disease. Long-term management of RA is carried out using disease-modifying antirheumatic drugs (DMARDs). Therapy of acute flares can be done with Non-steroidal anti-inflammatory drugs (NSAIDs) accompanied by ad interim usage of glucocorticoids. Biologic response modifiers are also available; they act by abolishing the activity of T- cells. However, it is necessary to select the correct treatment regimen when it comes to the management of RA in pregnancy.</description><identifier>ISSN: 0925-4692</identifier><identifier>EISSN: 1568-5608</identifier><identifier>DOI: 10.1007/s10787-021-00808-9</identifier><identifier>PMID: 33844107</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Allergology ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; Antirheumatic Agents - pharmacology ; Antirheumatic Agents - therapeutic use ; Arthritis, Rheumatoid - drug therapy ; Arthritis, Rheumatoid - immunology ; Arthritis, Rheumatoid - metabolism ; Biological Products - pharmacology ; Biological Products - therapeutic use ; Biomedical and Life Sciences ; Biomedicine ; Dermatology ; Disease Management ; Female ; Gastroenterology ; Glucocorticoids - pharmacology ; Glucocorticoids - therapeutic use ; Humans ; Immunology ; Pharmacology/Toxicology ; Pregnancy ; Pregnancy Complications - drug therapy ; Pregnancy Complications - immunology ; Pregnancy Complications - metabolism ; Review ; Rheumatology ; Synovial Membrane - drug effects ; Synovial Membrane - immunology ; Synovial Membrane - metabolism</subject><ispartof>Inflammopharmacology, 2021-08, Vol.29 (4), p.987-1000</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Switzerland AG 2021</rights><rights>2021. 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P. Prudhvi</creatorcontrib><creatorcontrib>Padinjakkara, Gayathry</creatorcontrib><creatorcontrib>Das, Akanksh</creatorcontrib><creatorcontrib>Vada, Surendra</creatorcontrib><creatorcontrib>Mudagal, Manjunatha P.</creatorcontrib><title>The positive effect of pregnancy in rheumatoid arthritis and the use of medications for the management of rheumatoid arthritis during pregnancy</title><title>Inflammopharmacology</title><addtitle>Inflammopharmacol</addtitle><addtitle>Inflammopharmacology</addtitle><description>Rheumatoid arthritis (RA) is an autoimmune systemic inflammatory disorder that is mostly characterised by progressive symmetrical joint destruction, particularly in the wrist and fingers, while it may also affect additional joints and several organs, such as the skin, heart, blood vessels, and lungs. It is identified by raised anti-rheumatoid factor and anti-cyclic citrullinated peptide antibodies. The chemical mediators involved in the activity of RA are IL-1β, TNF-α, and IL-6. Pregnancy exerts a positive effect on RA that helps to modulate the disease condition. Different hypotheses are recommended to explain the ameliorating effect of pregnancy in RA. RA cannot be completely cured. The treatment goal is the attrition of pain and inflammation and the further progression of the disease. Long-term management of RA is carried out using disease-modifying antirheumatic drugs (DMARDs). Therapy of acute flares can be done with Non-steroidal anti-inflammatory drugs (NSAIDs) accompanied by ad interim usage of glucocorticoids. Biologic response modifiers are also available; they act by abolishing the activity of T- cells. However, it is necessary to select the correct treatment regimen when it comes to the management of RA in pregnancy.</description><subject>Allergology</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</subject><subject>Antirheumatic Agents - pharmacology</subject><subject>Antirheumatic Agents - therapeutic use</subject><subject>Arthritis, Rheumatoid - drug therapy</subject><subject>Arthritis, Rheumatoid - immunology</subject><subject>Arthritis, Rheumatoid - metabolism</subject><subject>Biological Products - pharmacology</subject><subject>Biological Products - therapeutic use</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Dermatology</subject><subject>Disease Management</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Glucocorticoids - pharmacology</subject><subject>Glucocorticoids - therapeutic use</subject><subject>Humans</subject><subject>Immunology</subject><subject>Pharmacology/Toxicology</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - drug therapy</subject><subject>Pregnancy Complications - immunology</subject><subject>Pregnancy Complications - metabolism</subject><subject>Review</subject><subject>Rheumatology</subject><subject>Synovial Membrane - drug effects</subject><subject>Synovial Membrane - immunology</subject><subject>Synovial Membrane - metabolism</subject><issn>0925-4692</issn><issn>1568-5608</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kb1u3DAQhInAhn0--wVSBCzTyFlSPxTLwIgTAwbSXGqCIpd3PJxIhZQM-CnyypHuHKcxXG2x881iZwj5yOCWAYgvmYFoRQGcFQAttIX8QFasbtqibqA9IyuQvC6qRvJLcpXzHgAa0cgLclmWbVXN9Ir82eyQDjH70T8hRefQjDQ6OiTcBh3MM_WBph1OvR6jt1SncZdmcaY6WDrO8JRxAXq03ujRx5Cpi-m46nXQW-wxHC3fdLFT8mH7_9w1OXf6kPHmZa7Jr_tvm7sfxePP7w93Xx8LU1ZiLBzjpp6f4Z0VnQRuu0oyy6S1pq46xzUKUVpbSemkA23qjnEBTdeIzjqjZbkmn0--Q4q_J8yj6n02eDjogHHKiteMtbIuq0XKT1KTYs4JnRqS73V6VgzUUoQ6FaHmItSxCLVAn178p26O5hX5l_wsKE-CPCwJYFL7OKUw__ye7V_pJJeo</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Sharma, Uday Raj</creator><creator>Nediyedath Rathnakaran, Akhila</creator><creator>Raj, B. 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P. Prudhvi</creatorcontrib><creatorcontrib>Padinjakkara, Gayathry</creatorcontrib><creatorcontrib>Das, Akanksh</creatorcontrib><creatorcontrib>Vada, Surendra</creatorcontrib><creatorcontrib>Mudagal, Manjunatha P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Inflammopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sharma, Uday Raj</au><au>Nediyedath Rathnakaran, Akhila</au><au>Raj, B. P. 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| ispartof | Inflammopharmacology, 2021-08, Vol.29 (4), p.987-1000 |
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| subjects | Allergology Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Antirheumatic Agents - pharmacology Antirheumatic Agents - therapeutic use Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - metabolism Biological Products - pharmacology Biological Products - therapeutic use Biomedical and Life Sciences Biomedicine Dermatology Disease Management Female Gastroenterology Glucocorticoids - pharmacology Glucocorticoids - therapeutic use Humans Immunology Pharmacology/Toxicology Pregnancy Pregnancy Complications - drug therapy Pregnancy Complications - immunology Pregnancy Complications - metabolism Review Rheumatology Synovial Membrane - drug effects Synovial Membrane - immunology Synovial Membrane - metabolism |
| title | The positive effect of pregnancy in rheumatoid arthritis and the use of medications for the management of rheumatoid arthritis during pregnancy |
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