On the Role of Normal Aging Processes in the Onset and Pathogenesis of Diseases Associated with the Abnormal Accumulation of Protein Aggregates
Aging is a prime systemic cause of various age-related diseases, in particular, proteinopathies. In fact, most diseases associated with protein misfolding are sporadic, and their incidence increases with aging. This review examines the process of protein aggregate formation, the toxicity of such agg...
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Veröffentlicht in: | Biochemistry (Moscow) 2021-03, Vol.86 (3), p.275-289 |
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creator | Ilyinsky, Nikolay S. Nesterov, Semen V. Shestoperova, Elizaveta I. Fonin, Alexander V. Uversky, Vladimir N. Gordeliy, Valentin I. |
description | Aging is a prime systemic cause of various age-related diseases, in particular, proteinopathies. In fact, most diseases associated with protein misfolding are sporadic, and their incidence increases with aging. This review examines the process of protein aggregate formation, the toxicity of such aggregates, the organization of cellular systems involved in proteostasis, and the impact of protein aggregates on important cellular processes leading to proteinopathies. We also analyze how manifestations of aging (mitochondrial dysfunction, dysfunction of signaling systems, changes in the genome and epigenome) facilitate pathogenesis of various proteinopathies either directly, by increasing the propensity of key proteins for aggregation, or indirectly, through dysregulation of stress responses. Such analysis might help in outlining approaches for treating proteinopathies and extending healthy longevity. |
doi_str_mv | 10.1134/S0006297921030056 |
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In fact, most diseases associated with protein misfolding are sporadic, and their incidence increases with aging. This review examines the process of protein aggregate formation, the toxicity of such aggregates, the organization of cellular systems involved in proteostasis, and the impact of protein aggregates on important cellular processes leading to proteinopathies. We also analyze how manifestations of aging (mitochondrial dysfunction, dysfunction of signaling systems, changes in the genome and epigenome) facilitate pathogenesis of various proteinopathies either directly, by increasing the propensity of key proteins for aggregation, or indirectly, through dysregulation of stress responses. 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In fact, most diseases associated with protein misfolding are sporadic, and their incidence increases with aging. This review examines the process of protein aggregate formation, the toxicity of such aggregates, the organization of cellular systems involved in proteostasis, and the impact of protein aggregates on important cellular processes leading to proteinopathies. We also analyze how manifestations of aging (mitochondrial dysfunction, dysfunction of signaling systems, changes in the genome and epigenome) facilitate pathogenesis of various proteinopathies either directly, by increasing the propensity of key proteins for aggregation, or indirectly, through dysregulation of stress responses. Such analysis might help in outlining approaches for treating proteinopathies and extending healthy longevity.</description><subject>Age related diseases</subject><subject>Aggregates</subject><subject>Aging</subject><subject>Analysis</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bioorganic Chemistry</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Microbiology</subject><subject>Mitochondria</subject><subject>Mitochondria - metabolism</subject><subject>Mitochondria - pathology</subject><subject>Neurodegenerative Diseases - etiology</subject><subject>Neurodegenerative Diseases - metabolism</subject><subject>Neurodegenerative Diseases - physiopathology</subject><subject>Pathogenesis</subject><subject>Protein Aggregation, Pathological</subject><subject>Protein folding</subject><subject>Proteins</subject><subject>Proteostasis</subject><subject>Proteostasis Deficiencies - etiology</subject><subject>Proteostasis Deficiencies - metabolism</subject><subject>Proteostasis Deficiencies - physiopathology</subject><subject>Review</subject><subject>Signalling systems</subject><subject>Telecommunication systems</subject><subject>Toxicity</subject><issn>0006-2979</issn><issn>1608-3040</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kstu1DAUhi1ERYfCA7BBltiwSXscJ46zjAoFpKpTcVlHjnOScZXYxXaEeApeuQ4zUJWLvLDs832_j2UT8oLBKWO8OPsEACKvqzpnwAFK8YhsmACZcSjgMdms5WytH5OnIdykZQ41f0KOOZdcJnNDfmwtjTukH92E1A30yvlZTbQZjR3ptXcaQ8BAzZ7a2oCRKtvTaxV3bkSLwYTVe2MCqpVsQnDaqIg9_Wbi7qfWdPYQq_UyL5OKxtnVSgdETNnNOHockxSekaNBTQGfH-YT8uXi7efz99nl9t2H8-Yy0wWvY9YXUrOKDSXru6qQILDSui4GUF3ZCak64CXAAKziXQ0SAbGvueJFkcpa5PyEvN7n3nr3dcEQ29kEjdOkLLoltHnJmKyLXPKEvvoDvXGLt6m7RAHjpahkfU-NasLW2MFFr_Qa2jaiFIwJCVWiTv9BpdHjbLSzOJi0_0Bge0F7F4LHob31Zlb-e8ugXT9B-9cnSM7LQ8NLN2P_2_j16gnI90BIJTuiv7_R_1PvAPcuuZI</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Ilyinsky, Nikolay S.</creator><creator>Nesterov, Semen V.</creator><creator>Shestoperova, Elizaveta I.</creator><creator>Fonin, Alexander V.</creator><creator>Uversky, Vladimir N.</creator><creator>Gordeliy, Valentin I.</creator><general>Pleiades Publishing</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20210301</creationdate><title>On the Role of Normal Aging Processes in the Onset and Pathogenesis of Diseases Associated with the Abnormal Accumulation of Protein Aggregates</title><author>Ilyinsky, Nikolay S. ; Nesterov, Semen V. ; Shestoperova, Elizaveta I. ; Fonin, Alexander V. ; Uversky, Vladimir N. ; Gordeliy, Valentin I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-d48c171f51db74806e7cc94f0ab5b68ab03500f0173b908e0eed93a3445b6c623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Age related diseases</topic><topic>Aggregates</topic><topic>Aging</topic><topic>Analysis</topic><topic>Animals</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bioorganic Chemistry</topic><topic>Genomes</topic><topic>Genomics</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Microbiology</topic><topic>Mitochondria</topic><topic>Mitochondria - 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Academic</collection><jtitle>Biochemistry (Moscow)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ilyinsky, Nikolay S.</au><au>Nesterov, Semen V.</au><au>Shestoperova, Elizaveta I.</au><au>Fonin, Alexander V.</au><au>Uversky, Vladimir N.</au><au>Gordeliy, Valentin I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>On the Role of Normal Aging Processes in the Onset and Pathogenesis of Diseases Associated with the Abnormal Accumulation of Protein Aggregates</atitle><jtitle>Biochemistry (Moscow)</jtitle><stitle>Biochemistry Moscow</stitle><addtitle>Biochemistry (Mosc)</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>86</volume><issue>3</issue><spage>275</spage><epage>289</epage><pages>275-289</pages><issn>0006-2979</issn><eissn>1608-3040</eissn><abstract>Aging is a prime systemic cause of various age-related diseases, in particular, proteinopathies. In fact, most diseases associated with protein misfolding are sporadic, and their incidence increases with aging. This review examines the process of protein aggregate formation, the toxicity of such aggregates, the organization of cellular systems involved in proteostasis, and the impact of protein aggregates on important cellular processes leading to proteinopathies. We also analyze how manifestations of aging (mitochondrial dysfunction, dysfunction of signaling systems, changes in the genome and epigenome) facilitate pathogenesis of various proteinopathies either directly, by increasing the propensity of key proteins for aggregation, or indirectly, through dysregulation of stress responses. Such analysis might help in outlining approaches for treating proteinopathies and extending healthy longevity.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><pmid>33838629</pmid><doi>10.1134/S0006297921030056</doi><tpages>15</tpages></addata></record> |
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subjects | Age related diseases Aggregates Aging Analysis Animals Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Genomes Genomics Humans Life Sciences Microbiology Mitochondria Mitochondria - metabolism Mitochondria - pathology Neurodegenerative Diseases - etiology Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - physiopathology Pathogenesis Protein Aggregation, Pathological Protein folding Proteins Proteostasis Proteostasis Deficiencies - etiology Proteostasis Deficiencies - metabolism Proteostasis Deficiencies - physiopathology Review Signalling systems Telecommunication systems Toxicity |
title | On the Role of Normal Aging Processes in the Onset and Pathogenesis of Diseases Associated with the Abnormal Accumulation of Protein Aggregates |
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