On the Role of Normal Aging Processes in the Onset and Pathogenesis of Diseases Associated with the Abnormal Accumulation of Protein Aggregates

Aging is a prime systemic cause of various age-related diseases, in particular, proteinopathies. In fact, most diseases associated with protein misfolding are sporadic, and their incidence increases with aging. This review examines the process of protein aggregate formation, the toxicity of such agg...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Biochemistry (Moscow) 2021-03, Vol.86 (3), p.275-289
Hauptverfasser: Ilyinsky, Nikolay S., Nesterov, Semen V., Shestoperova, Elizaveta I., Fonin, Alexander V., Uversky, Vladimir N., Gordeliy, Valentin I.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 289
container_issue 3
container_start_page 275
container_title Biochemistry (Moscow)
container_volume 86
creator Ilyinsky, Nikolay S.
Nesterov, Semen V.
Shestoperova, Elizaveta I.
Fonin, Alexander V.
Uversky, Vladimir N.
Gordeliy, Valentin I.
description Aging is a prime systemic cause of various age-related diseases, in particular, proteinopathies. In fact, most diseases associated with protein misfolding are sporadic, and their incidence increases with aging. This review examines the process of protein aggregate formation, the toxicity of such aggregates, the organization of cellular systems involved in proteostasis, and the impact of protein aggregates on important cellular processes leading to proteinopathies. We also analyze how manifestations of aging (mitochondrial dysfunction, dysfunction of signaling systems, changes in the genome and epigenome) facilitate pathogenesis of various proteinopathies either directly, by increasing the propensity of key proteins for aggregation, or indirectly, through dysregulation of stress responses. Such analysis might help in outlining approaches for treating proteinopathies and extending healthy longevity.
doi_str_mv 10.1134/S0006297921030056
format Article
fullrecord <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2511894283</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A656116807</galeid><sourcerecordid>A656116807</sourcerecordid><originalsourceid>FETCH-LOGICAL-c439t-d48c171f51db74806e7cc94f0ab5b68ab03500f0173b908e0eed93a3445b6c623</originalsourceid><addsrcrecordid>eNp1kstu1DAUhi1ERYfCA7BBltiwSXscJ46zjAoFpKpTcVlHjnOScZXYxXaEeApeuQ4zUJWLvLDs832_j2UT8oLBKWO8OPsEACKvqzpnwAFK8YhsmACZcSjgMdms5WytH5OnIdykZQ41f0KOOZdcJnNDfmwtjTukH92E1A30yvlZTbQZjR3ptXcaQ8BAzZ7a2oCRKtvTaxV3bkSLwYTVe2MCqpVsQnDaqIg9_Wbi7qfWdPYQq_UyL5OKxtnVSgdETNnNOHockxSekaNBTQGfH-YT8uXi7efz99nl9t2H8-Yy0wWvY9YXUrOKDSXru6qQILDSui4GUF3ZCak64CXAAKziXQ0SAbGvueJFkcpa5PyEvN7n3nr3dcEQ29kEjdOkLLoltHnJmKyLXPKEvvoDvXGLt6m7RAHjpahkfU-NasLW2MFFr_Qa2jaiFIwJCVWiTv9BpdHjbLSzOJi0_0Bge0F7F4LHob31Zlb-e8ugXT9B-9cnSM7LQ8NLN2P_2_j16gnI90BIJTuiv7_R_1PvAPcuuZI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2501356789</pqid></control><display><type>article</type><title>On the Role of Normal Aging Processes in the Onset and Pathogenesis of Diseases Associated with the Abnormal Accumulation of Protein Aggregates</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Ilyinsky, Nikolay S. ; Nesterov, Semen V. ; Shestoperova, Elizaveta I. ; Fonin, Alexander V. ; Uversky, Vladimir N. ; Gordeliy, Valentin I.</creator><creatorcontrib>Ilyinsky, Nikolay S. ; Nesterov, Semen V. ; Shestoperova, Elizaveta I. ; Fonin, Alexander V. ; Uversky, Vladimir N. ; Gordeliy, Valentin I.</creatorcontrib><description>Aging is a prime systemic cause of various age-related diseases, in particular, proteinopathies. In fact, most diseases associated with protein misfolding are sporadic, and their incidence increases with aging. This review examines the process of protein aggregate formation, the toxicity of such aggregates, the organization of cellular systems involved in proteostasis, and the impact of protein aggregates on important cellular processes leading to proteinopathies. We also analyze how manifestations of aging (mitochondrial dysfunction, dysfunction of signaling systems, changes in the genome and epigenome) facilitate pathogenesis of various proteinopathies either directly, by increasing the propensity of key proteins for aggregation, or indirectly, through dysregulation of stress responses. Such analysis might help in outlining approaches for treating proteinopathies and extending healthy longevity.</description><identifier>ISSN: 0006-2979</identifier><identifier>EISSN: 1608-3040</identifier><identifier>DOI: 10.1134/S0006297921030056</identifier><identifier>PMID: 33838629</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Age related diseases ; Aggregates ; Aging ; Analysis ; Animals ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Bioorganic Chemistry ; Genomes ; Genomics ; Humans ; Life Sciences ; Microbiology ; Mitochondria ; Mitochondria - metabolism ; Mitochondria - pathology ; Neurodegenerative Diseases - etiology ; Neurodegenerative Diseases - metabolism ; Neurodegenerative Diseases - physiopathology ; Pathogenesis ; Protein Aggregation, Pathological ; Protein folding ; Proteins ; Proteostasis ; Proteostasis Deficiencies - etiology ; Proteostasis Deficiencies - metabolism ; Proteostasis Deficiencies - physiopathology ; Review ; Signalling systems ; Telecommunication systems ; Toxicity</subject><ispartof>Biochemistry (Moscow), 2021-03, Vol.86 (3), p.275-289</ispartof><rights>Pleiades Publishing, Ltd. 2021</rights><rights>COPYRIGHT 2021 Springer</rights><rights>Pleiades Publishing, Ltd. 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-d48c171f51db74806e7cc94f0ab5b68ab03500f0173b908e0eed93a3445b6c623</citedby><cites>FETCH-LOGICAL-c439t-d48c171f51db74806e7cc94f0ab5b68ab03500f0173b908e0eed93a3445b6c623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S0006297921030056$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S0006297921030056$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33838629$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ilyinsky, Nikolay S.</creatorcontrib><creatorcontrib>Nesterov, Semen V.</creatorcontrib><creatorcontrib>Shestoperova, Elizaveta I.</creatorcontrib><creatorcontrib>Fonin, Alexander V.</creatorcontrib><creatorcontrib>Uversky, Vladimir N.</creatorcontrib><creatorcontrib>Gordeliy, Valentin I.</creatorcontrib><title>On the Role of Normal Aging Processes in the Onset and Pathogenesis of Diseases Associated with the Abnormal Accumulation of Protein Aggregates</title><title>Biochemistry (Moscow)</title><addtitle>Biochemistry Moscow</addtitle><addtitle>Biochemistry (Mosc)</addtitle><description>Aging is a prime systemic cause of various age-related diseases, in particular, proteinopathies. In fact, most diseases associated with protein misfolding are sporadic, and their incidence increases with aging. This review examines the process of protein aggregate formation, the toxicity of such aggregates, the organization of cellular systems involved in proteostasis, and the impact of protein aggregates on important cellular processes leading to proteinopathies. We also analyze how manifestations of aging (mitochondrial dysfunction, dysfunction of signaling systems, changes in the genome and epigenome) facilitate pathogenesis of various proteinopathies either directly, by increasing the propensity of key proteins for aggregation, or indirectly, through dysregulation of stress responses. Such analysis might help in outlining approaches for treating proteinopathies and extending healthy longevity.</description><subject>Age related diseases</subject><subject>Aggregates</subject><subject>Aging</subject><subject>Analysis</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bioorganic Chemistry</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Microbiology</subject><subject>Mitochondria</subject><subject>Mitochondria - metabolism</subject><subject>Mitochondria - pathology</subject><subject>Neurodegenerative Diseases - etiology</subject><subject>Neurodegenerative Diseases - metabolism</subject><subject>Neurodegenerative Diseases - physiopathology</subject><subject>Pathogenesis</subject><subject>Protein Aggregation, Pathological</subject><subject>Protein folding</subject><subject>Proteins</subject><subject>Proteostasis</subject><subject>Proteostasis Deficiencies - etiology</subject><subject>Proteostasis Deficiencies - metabolism</subject><subject>Proteostasis Deficiencies - physiopathology</subject><subject>Review</subject><subject>Signalling systems</subject><subject>Telecommunication systems</subject><subject>Toxicity</subject><issn>0006-2979</issn><issn>1608-3040</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kstu1DAUhi1ERYfCA7BBltiwSXscJ46zjAoFpKpTcVlHjnOScZXYxXaEeApeuQ4zUJWLvLDs832_j2UT8oLBKWO8OPsEACKvqzpnwAFK8YhsmACZcSjgMdms5WytH5OnIdykZQ41f0KOOZdcJnNDfmwtjTukH92E1A30yvlZTbQZjR3ptXcaQ8BAzZ7a2oCRKtvTaxV3bkSLwYTVe2MCqpVsQnDaqIg9_Wbi7qfWdPYQq_UyL5OKxtnVSgdETNnNOHockxSekaNBTQGfH-YT8uXi7efz99nl9t2H8-Yy0wWvY9YXUrOKDSXru6qQILDSui4GUF3ZCak64CXAAKziXQ0SAbGvueJFkcpa5PyEvN7n3nr3dcEQ29kEjdOkLLoltHnJmKyLXPKEvvoDvXGLt6m7RAHjpahkfU-NasLW2MFFr_Qa2jaiFIwJCVWiTv9BpdHjbLSzOJi0_0Bge0F7F4LHob31Zlb-e8ugXT9B-9cnSM7LQ8NLN2P_2_j16gnI90BIJTuiv7_R_1PvAPcuuZI</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Ilyinsky, Nikolay S.</creator><creator>Nesterov, Semen V.</creator><creator>Shestoperova, Elizaveta I.</creator><creator>Fonin, Alexander V.</creator><creator>Uversky, Vladimir N.</creator><creator>Gordeliy, Valentin I.</creator><general>Pleiades Publishing</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20210301</creationdate><title>On the Role of Normal Aging Processes in the Onset and Pathogenesis of Diseases Associated with the Abnormal Accumulation of Protein Aggregates</title><author>Ilyinsky, Nikolay S. ; Nesterov, Semen V. ; Shestoperova, Elizaveta I. ; Fonin, Alexander V. ; Uversky, Vladimir N. ; Gordeliy, Valentin I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-d48c171f51db74806e7cc94f0ab5b68ab03500f0173b908e0eed93a3445b6c623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Age related diseases</topic><topic>Aggregates</topic><topic>Aging</topic><topic>Analysis</topic><topic>Animals</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bioorganic Chemistry</topic><topic>Genomes</topic><topic>Genomics</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Microbiology</topic><topic>Mitochondria</topic><topic>Mitochondria - metabolism</topic><topic>Mitochondria - pathology</topic><topic>Neurodegenerative Diseases - etiology</topic><topic>Neurodegenerative Diseases - metabolism</topic><topic>Neurodegenerative Diseases - physiopathology</topic><topic>Pathogenesis</topic><topic>Protein Aggregation, Pathological</topic><topic>Protein folding</topic><topic>Proteins</topic><topic>Proteostasis</topic><topic>Proteostasis Deficiencies - etiology</topic><topic>Proteostasis Deficiencies - metabolism</topic><topic>Proteostasis Deficiencies - physiopathology</topic><topic>Review</topic><topic>Signalling systems</topic><topic>Telecommunication systems</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ilyinsky, Nikolay S.</creatorcontrib><creatorcontrib>Nesterov, Semen V.</creatorcontrib><creatorcontrib>Shestoperova, Elizaveta I.</creatorcontrib><creatorcontrib>Fonin, Alexander V.</creatorcontrib><creatorcontrib>Uversky, Vladimir N.</creatorcontrib><creatorcontrib>Gordeliy, Valentin I.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemistry (Moscow)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ilyinsky, Nikolay S.</au><au>Nesterov, Semen V.</au><au>Shestoperova, Elizaveta I.</au><au>Fonin, Alexander V.</au><au>Uversky, Vladimir N.</au><au>Gordeliy, Valentin I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>On the Role of Normal Aging Processes in the Onset and Pathogenesis of Diseases Associated with the Abnormal Accumulation of Protein Aggregates</atitle><jtitle>Biochemistry (Moscow)</jtitle><stitle>Biochemistry Moscow</stitle><addtitle>Biochemistry (Mosc)</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>86</volume><issue>3</issue><spage>275</spage><epage>289</epage><pages>275-289</pages><issn>0006-2979</issn><eissn>1608-3040</eissn><abstract>Aging is a prime systemic cause of various age-related diseases, in particular, proteinopathies. In fact, most diseases associated with protein misfolding are sporadic, and their incidence increases with aging. This review examines the process of protein aggregate formation, the toxicity of such aggregates, the organization of cellular systems involved in proteostasis, and the impact of protein aggregates on important cellular processes leading to proteinopathies. We also analyze how manifestations of aging (mitochondrial dysfunction, dysfunction of signaling systems, changes in the genome and epigenome) facilitate pathogenesis of various proteinopathies either directly, by increasing the propensity of key proteins for aggregation, or indirectly, through dysregulation of stress responses. Such analysis might help in outlining approaches for treating proteinopathies and extending healthy longevity.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><pmid>33838629</pmid><doi>10.1134/S0006297921030056</doi><tpages>15</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0006-2979
ispartof Biochemistry (Moscow), 2021-03, Vol.86 (3), p.275-289
issn 0006-2979
1608-3040
language eng
recordid cdi_proquest_miscellaneous_2511894283
source MEDLINE; SpringerLink Journals
subjects Age related diseases
Aggregates
Aging
Analysis
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Genomes
Genomics
Humans
Life Sciences
Microbiology
Mitochondria
Mitochondria - metabolism
Mitochondria - pathology
Neurodegenerative Diseases - etiology
Neurodegenerative Diseases - metabolism
Neurodegenerative Diseases - physiopathology
Pathogenesis
Protein Aggregation, Pathological
Protein folding
Proteins
Proteostasis
Proteostasis Deficiencies - etiology
Proteostasis Deficiencies - metabolism
Proteostasis Deficiencies - physiopathology
Review
Signalling systems
Telecommunication systems
Toxicity
title On the Role of Normal Aging Processes in the Onset and Pathogenesis of Diseases Associated with the Abnormal Accumulation of Protein Aggregates
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T12%3A25%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=On%20the%20Role%20of%20Normal%20Aging%20Processes%20in%20the%20Onset%20and%20Pathogenesis%20of%20Diseases%20Associated%20with%20the%20Abnormal%20Accumulation%20of%20Protein%20Aggregates&rft.jtitle=Biochemistry%20(Moscow)&rft.au=Ilyinsky,%20Nikolay%20S.&rft.date=2021-03-01&rft.volume=86&rft.issue=3&rft.spage=275&rft.epage=289&rft.pages=275-289&rft.issn=0006-2979&rft.eissn=1608-3040&rft_id=info:doi/10.1134/S0006297921030056&rft_dat=%3Cgale_proqu%3EA656116807%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2501356789&rft_id=info:pmid/33838629&rft_galeid=A656116807&rfr_iscdi=true