Endothelial function and its determinants in children born after maternal bariatric surgery
Background Children born from mothers who underwent bariatric surgery were found to have an improved lipid profile and lower CRP levels compared to siblings born before surgery. We hypothesized that surgery before pregnancy might also influence endothelial function in the offspring. Methods Blood sa...
Gespeichert in:
| Veröffentlicht in: | Pediatric research 2022-02, Vol.91 (3), p.699-704 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 704 |
|---|---|
| container_issue | 3 |
| container_start_page | 699 |
| container_title | Pediatric research |
| container_volume | 91 |
| creator | Van De Maele, Karolien Devlieger, Roland De Schepper, Jean Gies, Inge |
| description | Background
Children born from mothers who underwent bariatric surgery were found to have an improved lipid profile and lower CRP levels compared to siblings born before surgery. We hypothesized that surgery before pregnancy might also influence endothelial function in the offspring.
Methods
Blood sample analysis, blood pressure (BP) measurement, and peripheral arterial tonometry (PAT) were performed in 142 children (median age 10.5 years), either born from mothers who underwent bariatric surgery (BS) before pregnancy (
n
= 36) from mothers with overweight/obesity (OW/OB) (
n
= 71) or from normal weight (NW) mothers (
n
= 35), allowing the determination of the Reactive Hyperemia Index (RHI) in 111 children.
Results
Children of the BS group had a higher diastolic blood pressure SDS and a lower RHI compared to the children of the OW/OB and NW group (1.32 versus 1.37 in OW/OB and 1.70 in NW;
p
= 0.004). After log transformation and correction for age, weight SDS, BMI SDS, body fat percentage, and diastolic BP SDS, RHI was comparable between the groups.
Conclusions
Children of mothers who underwent bariatric surgery before pregnancy do not have a disturbed endothelial function before puberty, when their increased diastolic BP and degree of adiposity is taken into account.
Impact
Children born after maternal bariatric surgery have a higher diastolic blood pressure without impaired endothelial function.
To our knowledge, this is the first study that investigates the vascular function of children based on maternal characteristics during pregnancy.
Adult offspring of mothers with obesity during pregnancy have an increased cardiovascular mortality. Since we cannot demonstrate a childhood-onset primary vascular dysfunction, this cardiovascular vulnerability might be more related to the hypertension and body adiposity. Thus, more emphasis should be made on the prevention of obesity and hypertension in the offspring at risk for development of obesity. |
| doi_str_mv | 10.1038/s41390-021-01500-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2511245563</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2637579053</sourcerecordid><originalsourceid>FETCH-LOGICAL-c419t-48d0c788d747d1c408fe602849eafe10c38e158afc6434faf2114dc075079d0b3</originalsourceid><addsrcrecordid>eNp9kL1u2zAURokiQe2kfYEMgYAsXdTcK5IiNRZBmhQw0CWZMhA0f2oaEuWS0uC3Dx27KdChCwnynu8jcQi5QviKQOVtZkg7qKHBGpAD1PsPZImclivGxBlZAlCsadfJBbnIeQuAjEv2kSwolVQ0vF2Sl_tox2nj-qD7ys_RTGGMlY62ClOurJtcGkLUsRxCrMwm9Da5WK3HVChfptWgyxpLeq1T0FMKpspz-uXS_hM597rP7vNpvyTP3--f7h7r1c-HH3ffVrVh2E01kxaMkNIKJiwaBtK7FhrJOqe9QzBUOuRSe9Myyrz2DSKzBgQH0VlY00vy5di7S-Pv2eVJDSEb1_c6unHOquGIDeO8pQW9-QfdjvPh94VqqeCiA36gmiNl0phzcl7tUhh02isEdVCvjupVUa_e1Kt9CV2fquf14Ox75I_rAtAjkMsoFkF_3_5P7St4gI92</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2637579053</pqid></control><display><type>article</type><title>Endothelial function and its determinants in children born after maternal bariatric surgery</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Van De Maele, Karolien ; Devlieger, Roland ; De Schepper, Jean ; Gies, Inge</creator><creatorcontrib>Van De Maele, Karolien ; Devlieger, Roland ; De Schepper, Jean ; Gies, Inge</creatorcontrib><description>Background
Children born from mothers who underwent bariatric surgery were found to have an improved lipid profile and lower CRP levels compared to siblings born before surgery. We hypothesized that surgery before pregnancy might also influence endothelial function in the offspring.
Methods
Blood sample analysis, blood pressure (BP) measurement, and peripheral arterial tonometry (PAT) were performed in 142 children (median age 10.5 years), either born from mothers who underwent bariatric surgery (BS) before pregnancy (
n
= 36) from mothers with overweight/obesity (OW/OB) (
n
= 71) or from normal weight (NW) mothers (
n
= 35), allowing the determination of the Reactive Hyperemia Index (RHI) in 111 children.
Results
Children of the BS group had a higher diastolic blood pressure SDS and a lower RHI compared to the children of the OW/OB and NW group (1.32 versus 1.37 in OW/OB and 1.70 in NW;
p
= 0.004). After log transformation and correction for age, weight SDS, BMI SDS, body fat percentage, and diastolic BP SDS, RHI was comparable between the groups.
Conclusions
Children of mothers who underwent bariatric surgery before pregnancy do not have a disturbed endothelial function before puberty, when their increased diastolic BP and degree of adiposity is taken into account.
Impact
Children born after maternal bariatric surgery have a higher diastolic blood pressure without impaired endothelial function.
To our knowledge, this is the first study that investigates the vascular function of children based on maternal characteristics during pregnancy.
Adult offspring of mothers with obesity during pregnancy have an increased cardiovascular mortality. Since we cannot demonstrate a childhood-onset primary vascular dysfunction, this cardiovascular vulnerability might be more related to the hypertension and body adiposity. Thus, more emphasis should be made on the prevention of obesity and hypertension in the offspring at risk for development of obesity.</description><identifier>ISSN: 0031-3998</identifier><identifier>EISSN: 1530-0447</identifier><identifier>DOI: 10.1038/s41390-021-01500-y</identifier><identifier>PMID: 33837256</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Adult ; Bariatric Surgery ; Blood pressure ; Body Mass Index ; Child ; Female ; Gastrointestinal surgery ; Humans ; Hypertension ; Medicine ; Medicine & Public Health ; Obesity ; Overweight ; Pediatric Surgery ; Pediatrics ; Population Study Article ; Pregnancy ; Risk Factors</subject><ispartof>Pediatric research, 2022-02, Vol.91 (3), p.699-704</ispartof><rights>The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc 2021</rights><rights>2021. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.</rights><rights>The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc 2021.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-48d0c788d747d1c408fe602849eafe10c38e158afc6434faf2114dc075079d0b3</citedby><cites>FETCH-LOGICAL-c419t-48d0c788d747d1c408fe602849eafe10c38e158afc6434faf2114dc075079d0b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33837256$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Van De Maele, Karolien</creatorcontrib><creatorcontrib>Devlieger, Roland</creatorcontrib><creatorcontrib>De Schepper, Jean</creatorcontrib><creatorcontrib>Gies, Inge</creatorcontrib><title>Endothelial function and its determinants in children born after maternal bariatric surgery</title><title>Pediatric research</title><addtitle>Pediatr Res</addtitle><addtitle>Pediatr Res</addtitle><description>Background
Children born from mothers who underwent bariatric surgery were found to have an improved lipid profile and lower CRP levels compared to siblings born before surgery. We hypothesized that surgery before pregnancy might also influence endothelial function in the offspring.
Methods
Blood sample analysis, blood pressure (BP) measurement, and peripheral arterial tonometry (PAT) were performed in 142 children (median age 10.5 years), either born from mothers who underwent bariatric surgery (BS) before pregnancy (
n
= 36) from mothers with overweight/obesity (OW/OB) (
n
= 71) or from normal weight (NW) mothers (
n
= 35), allowing the determination of the Reactive Hyperemia Index (RHI) in 111 children.
Results
Children of the BS group had a higher diastolic blood pressure SDS and a lower RHI compared to the children of the OW/OB and NW group (1.32 versus 1.37 in OW/OB and 1.70 in NW;
p
= 0.004). After log transformation and correction for age, weight SDS, BMI SDS, body fat percentage, and diastolic BP SDS, RHI was comparable between the groups.
Conclusions
Children of mothers who underwent bariatric surgery before pregnancy do not have a disturbed endothelial function before puberty, when their increased diastolic BP and degree of adiposity is taken into account.
Impact
Children born after maternal bariatric surgery have a higher diastolic blood pressure without impaired endothelial function.
To our knowledge, this is the first study that investigates the vascular function of children based on maternal characteristics during pregnancy.
Adult offspring of mothers with obesity during pregnancy have an increased cardiovascular mortality. Since we cannot demonstrate a childhood-onset primary vascular dysfunction, this cardiovascular vulnerability might be more related to the hypertension and body adiposity. Thus, more emphasis should be made on the prevention of obesity and hypertension in the offspring at risk for development of obesity.</description><subject>Adult</subject><subject>Bariatric Surgery</subject><subject>Blood pressure</subject><subject>Body Mass Index</subject><subject>Child</subject><subject>Female</subject><subject>Gastrointestinal surgery</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Obesity</subject><subject>Overweight</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Population Study Article</subject><subject>Pregnancy</subject><subject>Risk Factors</subject><issn>0031-3998</issn><issn>1530-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kL1u2zAURokiQe2kfYEMgYAsXdTcK5IiNRZBmhQw0CWZMhA0f2oaEuWS0uC3Dx27KdChCwnynu8jcQi5QviKQOVtZkg7qKHBGpAD1PsPZImclivGxBlZAlCsadfJBbnIeQuAjEv2kSwolVQ0vF2Sl_tox2nj-qD7ys_RTGGMlY62ClOurJtcGkLUsRxCrMwm9Da5WK3HVChfptWgyxpLeq1T0FMKpspz-uXS_hM597rP7vNpvyTP3--f7h7r1c-HH3ffVrVh2E01kxaMkNIKJiwaBtK7FhrJOqe9QzBUOuRSe9Myyrz2DSKzBgQH0VlY00vy5di7S-Pv2eVJDSEb1_c6unHOquGIDeO8pQW9-QfdjvPh94VqqeCiA36gmiNl0phzcl7tUhh02isEdVCvjupVUa_e1Kt9CV2fquf14Ox75I_rAtAjkMsoFkF_3_5P7St4gI92</recordid><startdate>20220201</startdate><enddate>20220201</enddate><creator>Van De Maele, Karolien</creator><creator>Devlieger, Roland</creator><creator>De Schepper, Jean</creator><creator>Gies, Inge</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20220201</creationdate><title>Endothelial function and its determinants in children born after maternal bariatric surgery</title><author>Van De Maele, Karolien ; Devlieger, Roland ; De Schepper, Jean ; Gies, Inge</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-48d0c788d747d1c408fe602849eafe10c38e158afc6434faf2114dc075079d0b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adult</topic><topic>Bariatric Surgery</topic><topic>Blood pressure</topic><topic>Body Mass Index</topic><topic>Child</topic><topic>Female</topic><topic>Gastrointestinal surgery</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Obesity</topic><topic>Overweight</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Population Study Article</topic><topic>Pregnancy</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Van De Maele, Karolien</creatorcontrib><creatorcontrib>Devlieger, Roland</creatorcontrib><creatorcontrib>De Schepper, Jean</creatorcontrib><creatorcontrib>Gies, Inge</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Van De Maele, Karolien</au><au>Devlieger, Roland</au><au>De Schepper, Jean</au><au>Gies, Inge</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endothelial function and its determinants in children born after maternal bariatric surgery</atitle><jtitle>Pediatric research</jtitle><stitle>Pediatr Res</stitle><addtitle>Pediatr Res</addtitle><date>2022-02-01</date><risdate>2022</risdate><volume>91</volume><issue>3</issue><spage>699</spage><epage>704</epage><pages>699-704</pages><issn>0031-3998</issn><eissn>1530-0447</eissn><abstract>Background
Children born from mothers who underwent bariatric surgery were found to have an improved lipid profile and lower CRP levels compared to siblings born before surgery. We hypothesized that surgery before pregnancy might also influence endothelial function in the offspring.
Methods
Blood sample analysis, blood pressure (BP) measurement, and peripheral arterial tonometry (PAT) were performed in 142 children (median age 10.5 years), either born from mothers who underwent bariatric surgery (BS) before pregnancy (
n
= 36) from mothers with overweight/obesity (OW/OB) (
n
= 71) or from normal weight (NW) mothers (
n
= 35), allowing the determination of the Reactive Hyperemia Index (RHI) in 111 children.
Results
Children of the BS group had a higher diastolic blood pressure SDS and a lower RHI compared to the children of the OW/OB and NW group (1.32 versus 1.37 in OW/OB and 1.70 in NW;
p
= 0.004). After log transformation and correction for age, weight SDS, BMI SDS, body fat percentage, and diastolic BP SDS, RHI was comparable between the groups.
Conclusions
Children of mothers who underwent bariatric surgery before pregnancy do not have a disturbed endothelial function before puberty, when their increased diastolic BP and degree of adiposity is taken into account.
Impact
Children born after maternal bariatric surgery have a higher diastolic blood pressure without impaired endothelial function.
To our knowledge, this is the first study that investigates the vascular function of children based on maternal characteristics during pregnancy.
Adult offspring of mothers with obesity during pregnancy have an increased cardiovascular mortality. Since we cannot demonstrate a childhood-onset primary vascular dysfunction, this cardiovascular vulnerability might be more related to the hypertension and body adiposity. Thus, more emphasis should be made on the prevention of obesity and hypertension in the offspring at risk for development of obesity.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>33837256</pmid><doi>10.1038/s41390-021-01500-y</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-3998 |
| ispartof | Pediatric research, 2022-02, Vol.91 (3), p.699-704 |
| issn | 0031-3998 1530-0447 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2511245563 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Bariatric Surgery Blood pressure Body Mass Index Child Female Gastrointestinal surgery Humans Hypertension Medicine Medicine & Public Health Obesity Overweight Pediatric Surgery Pediatrics Population Study Article Pregnancy Risk Factors |
| title | Endothelial function and its determinants in children born after maternal bariatric surgery |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T14%3A39%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Endothelial%20function%20and%20its%20determinants%20in%20children%20born%20after%20maternal%20bariatric%20surgery&rft.jtitle=Pediatric%20research&rft.au=Van%20De%20Maele,%20Karolien&rft.date=2022-02-01&rft.volume=91&rft.issue=3&rft.spage=699&rft.epage=704&rft.pages=699-704&rft.issn=0031-3998&rft.eissn=1530-0447&rft_id=info:doi/10.1038/s41390-021-01500-y&rft_dat=%3Cproquest_cross%3E2637579053%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2637579053&rft_id=info:pmid/33837256&rfr_iscdi=true |