Effects of Nigella sativa oil and thymoquinone on radiation-induced oxidative stress in kidney tissue of rats

Effects of Nigella sativa oil and thymoquinone on radiation-induced oxidative stress in kidney tissue of rats

Ionizing radiation leads to release of free radicals into the systemic circulation from irradiated tissues. These free radicals cause oxidative stress in distant organs. Oxidative status may be reversed by naturally occurring antioxidant agents. The aim of this study was to investigate protective an...

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Veröffentlicht in:Biomedicine & pharmacotherapy 2021-07, Vol.139, p.111540-111540, Article 111540
Hauptverfasser: Alkis, Hilal, Demir, Elif, Taysi, Mehmet Resit, Sagir, Suleyman, Taysi, Seyithan
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Free radicals
Ionizing radiation
Kidney
Nigella sativa oil
Thymoquinone
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creator Alkis, Hilal
Demir, Elif
Taysi, Mehmet Resit
Sagir, Suleyman
Taysi, Seyithan
description Ionizing radiation leads to release of free radicals into the systemic circulation from irradiated tissues. These free radicals cause oxidative stress in distant organs. Oxidative status may be reversed by naturally occurring antioxidant agents. The aim of this study was to investigate protective and antioxidant effects of Nigella sativa oil (NSO) and thymoquinone (TQ) in kidney tissue of rats exposed to cranial irradiation. Forty-eight Sprague-Dawley rats were divided into six groups: IR group received irradiation (IR) to total cranium plus saline; IR plus NSO group received IR and NSO; IR plus TQ group received IR and TQ; sham group did not receive NSO, TQ or IR; control group of TQ received dimethyl sulfoxide; control group of NSO received saline. Total oxidant status (TOS), oxidative stress index (OSI) and lipid hydroperoxide (LOOH) levels were studied as oxidative parameters, and total antioxidant status (TAS), total sulfhydryl levels, paraoxonase (PON), ceruloplasmin (Cp) and arylesterase activities were determined as antioxidative parameters in the kidney tissue of rats. Kidney TOS, OSI and LOOH levels were significantly lower in IR plus TQ, IR plus NSO and sham groups compared to IR group (p 
doi_str_mv 10.1016/j.biopha.2021.111540
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These free radicals cause oxidative stress in distant organs. Oxidative status may be reversed by naturally occurring antioxidant agents. The aim of this study was to investigate protective and antioxidant effects of Nigella sativa oil (NSO) and thymoquinone (TQ) in kidney tissue of rats exposed to cranial irradiation. Forty-eight Sprague-Dawley rats were divided into six groups: IR group received irradiation (IR) to total cranium plus saline; IR plus NSO group received IR and NSO; IR plus TQ group received IR and TQ; sham group did not receive NSO, TQ or IR; control group of TQ received dimethyl sulfoxide; control group of NSO received saline. Total oxidant status (TOS), oxidative stress index (OSI) and lipid hydroperoxide (LOOH) levels were studied as oxidative parameters, and total antioxidant status (TAS), total sulfhydryl levels, paraoxonase (PON), ceruloplasmin (Cp) and arylesterase activities were determined as antioxidative parameters in the kidney tissue of rats. Kidney TOS, OSI and LOOH levels were significantly lower in IR plus TQ, IR plus NSO and sham groups compared to IR group (p &lt; 0.001). TAS, PON and Cp activities in IR group were significantly lower compared to the control group (p &lt; 0.001). PON and Cp activities were significantly higher in IR plus NSO and IR plus TQ groups compared to IR group (p &lt; 0.001). In conclusion, free radicals generated by cranial ionizing radiation exposure cause oxidative stress in kidney. NSO and TQ exhibit protective and antioxidant effects against oxidative damage in rats. [Display omitted] •Ionizing radiation leads to formation of free radicals and oxidative stress.•Release of free radicals into systemic circulation cause oxidative damage in kidney.•Nigella sativa oil and thymoquinone exhibit antioxidant and radioprotective effects.•Nigella sativa oil and thymoquinone can prevent kidneys against oxidative injury.</description><identifier>ISSN: 0753-3322</identifier><identifier>EISSN: 1950-6007</identifier><identifier>DOI: 10.1016/j.biopha.2021.111540</identifier><identifier>PMID: 33831837</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Free radicals ; Ionizing radiation ; Kidney ; Nigella sativa oil ; Thymoquinone</subject><ispartof>Biomedicine &amp; pharmacotherapy, 2021-07, Vol.139, p.111540-111540, Article 111540</ispartof><rights>2021 The Authors</rights><rights>Copyright © 2021 The Authors. Published by Elsevier Masson SAS.. 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These free radicals cause oxidative stress in distant organs. Oxidative status may be reversed by naturally occurring antioxidant agents. The aim of this study was to investigate protective and antioxidant effects of Nigella sativa oil (NSO) and thymoquinone (TQ) in kidney tissue of rats exposed to cranial irradiation. Forty-eight Sprague-Dawley rats were divided into six groups: IR group received irradiation (IR) to total cranium plus saline; IR plus NSO group received IR and NSO; IR plus TQ group received IR and TQ; sham group did not receive NSO, TQ or IR; control group of TQ received dimethyl sulfoxide; control group of NSO received saline. Total oxidant status (TOS), oxidative stress index (OSI) and lipid hydroperoxide (LOOH) levels were studied as oxidative parameters, and total antioxidant status (TAS), total sulfhydryl levels, paraoxonase (PON), ceruloplasmin (Cp) and arylesterase activities were determined as antioxidative parameters in the kidney tissue of rats. Kidney TOS, OSI and LOOH levels were significantly lower in IR plus TQ, IR plus NSO and sham groups compared to IR group (p &lt; 0.001). TAS, PON and Cp activities in IR group were significantly lower compared to the control group (p &lt; 0.001). PON and Cp activities were significantly higher in IR plus NSO and IR plus TQ groups compared to IR group (p &lt; 0.001). In conclusion, free radicals generated by cranial ionizing radiation exposure cause oxidative stress in kidney. NSO and TQ exhibit protective and antioxidant effects against oxidative damage in rats. [Display omitted] •Ionizing radiation leads to formation of free radicals and oxidative stress.•Release of free radicals into systemic circulation cause oxidative damage in kidney.•Nigella sativa oil and thymoquinone exhibit antioxidant and radioprotective effects.•Nigella sativa oil and thymoquinone can prevent kidneys against oxidative injury.</description><subject>Free radicals</subject><subject>Ionizing radiation</subject><subject>Kidney</subject><subject>Nigella sativa oil</subject><subject>Thymoquinone</subject><issn>0753-3322</issn><issn>1950-6007</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kE1P3DAQhq2Kqiy0_wAhH7lk64_YiS9IFaItEmov7dly4kmZZWMvdoLYf19HgR57Gmn0vPPxEHLB2ZYzrj_vth3Gw4PbCib4lnOuavaObLhRrNKMNSdkwxolKymFOCVnOe8YY0rL9gM5lbKVvJXNhoy3wwD9lGkc6A_8A_u9o9lN-OxoxD11wdPp4TjGpxlDDEBjoMl5LEQMFQY_9-BpfEG_ZIDmKUHOFAN9RB_gSCfMeYZlenJT_kjeD26f4dNrPSe_v97-uvle3f_8dnfz5b7qa9ZOlfSaq44xX8vaDQ1I55lRYJjvTA2qtLvBGd4MRrRgWq1db7QwWklvhPeNPCdX69xDKpdDnuyIuV-eCxDnbIXiXMi2aXVB6xXtU8w5wWAPCUeXjpYzu4i2O7uKtotou4ouscvXDXM3gv8XejNbgOsVgPLnM0KyuUcIRRemItz6iP_f8BfD2ZGy</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Alkis, Hilal</creator><creator>Demir, Elif</creator><creator>Taysi, Mehmet Resit</creator><creator>Sagir, Suleyman</creator><creator>Taysi, Seyithan</creator><general>Elsevier Masson SAS</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20210701</creationdate><title>Effects of Nigella sativa oil and thymoquinone on radiation-induced oxidative stress in kidney tissue of rats</title><author>Alkis, Hilal ; Demir, Elif ; Taysi, Mehmet Resit ; Sagir, Suleyman ; Taysi, Seyithan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-3d615b00d434af7e3ad095e90db94e5d43bfa917f928e9866ac9629653d92dd73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Free radicals</topic><topic>Ionizing radiation</topic><topic>Kidney</topic><topic>Nigella sativa oil</topic><topic>Thymoquinone</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alkis, Hilal</creatorcontrib><creatorcontrib>Demir, Elif</creatorcontrib><creatorcontrib>Taysi, Mehmet Resit</creatorcontrib><creatorcontrib>Sagir, Suleyman</creatorcontrib><creatorcontrib>Taysi, Seyithan</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomedicine &amp; pharmacotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alkis, Hilal</au><au>Demir, Elif</au><au>Taysi, Mehmet Resit</au><au>Sagir, Suleyman</au><au>Taysi, Seyithan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Nigella sativa oil and thymoquinone on radiation-induced oxidative stress in kidney tissue of rats</atitle><jtitle>Biomedicine &amp; pharmacotherapy</jtitle><addtitle>Biomed Pharmacother</addtitle><date>2021-07-01</date><risdate>2021</risdate><volume>139</volume><spage>111540</spage><epage>111540</epage><pages>111540-111540</pages><artnum>111540</artnum><issn>0753-3322</issn><eissn>1950-6007</eissn><abstract>Ionizing radiation leads to release of free radicals into the systemic circulation from irradiated tissues. These free radicals cause oxidative stress in distant organs. Oxidative status may be reversed by naturally occurring antioxidant agents. The aim of this study was to investigate protective and antioxidant effects of Nigella sativa oil (NSO) and thymoquinone (TQ) in kidney tissue of rats exposed to cranial irradiation. Forty-eight Sprague-Dawley rats were divided into six groups: IR group received irradiation (IR) to total cranium plus saline; IR plus NSO group received IR and NSO; IR plus TQ group received IR and TQ; sham group did not receive NSO, TQ or IR; control group of TQ received dimethyl sulfoxide; control group of NSO received saline. Total oxidant status (TOS), oxidative stress index (OSI) and lipid hydroperoxide (LOOH) levels were studied as oxidative parameters, and total antioxidant status (TAS), total sulfhydryl levels, paraoxonase (PON), ceruloplasmin (Cp) and arylesterase activities were determined as antioxidative parameters in the kidney tissue of rats. Kidney TOS, OSI and LOOH levels were significantly lower in IR plus TQ, IR plus NSO and sham groups compared to IR group (p &lt; 0.001). TAS, PON and Cp activities in IR group were significantly lower compared to the control group (p &lt; 0.001). PON and Cp activities were significantly higher in IR plus NSO and IR plus TQ groups compared to IR group (p &lt; 0.001). In conclusion, free radicals generated by cranial ionizing radiation exposure cause oxidative stress in kidney. NSO and TQ exhibit protective and antioxidant effects against oxidative damage in rats. [Display omitted] •Ionizing radiation leads to formation of free radicals and oxidative stress.•Release of free radicals into systemic circulation cause oxidative damage in kidney.•Nigella sativa oil and thymoquinone exhibit antioxidant and radioprotective effects.•Nigella sativa oil and thymoquinone can prevent kidneys against oxidative injury.</abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>33831837</pmid><doi>10.1016/j.biopha.2021.111540</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
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source Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
subjects Free radicals
Ionizing radiation
Kidney
Nigella sativa oil
Thymoquinone
title Effects of Nigella sativa oil and thymoquinone on radiation-induced oxidative stress in kidney tissue of rats
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