Association of interleukin-12B rs6887695 with susceptibility to allergic rhinitis
Interleukin-12 (IL-12) is a heterodimeric cytokine encoded by two separate genes, IL12A and IL12B, which may play a regulatory role in allergen-induced inflammation through CD4 + T-cell subsets polarization. The aim of this study was to investigate the association of single-nucleotide polymorphisms...
Gespeichert in:
| Veröffentlicht in: | Immunologic research 2021-04, Vol.69 (2), p.189-195 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 195 |
|---|---|
| container_issue | 2 |
| container_start_page | 189 |
| container_title | Immunologic research |
| container_volume | 69 |
| creator | Falahi, Sara Salari, Farhad Rezaiemanesh, Alireza Mortazavi, Seyed Hamidreza Koohyanizadeh, Farzaneh Lotfi, Ramin Gorgin Karaji, Ali |
| description | Interleukin-12 (IL-12) is a heterodimeric cytokine encoded by two separate genes, IL12A and IL12B, which may play a regulatory role in allergen-induced inflammation through CD4
+
T-cell subsets polarization. The aim of this study was to investigate the association of single-nucleotide polymorphisms (SNPs) in the IL12B gene with susceptibility to allergic rhinitis (AR). We performed a case–control study including 130 AR patients and 130 healthy controls to evaluate the possible association between IL12B gene SNPs (rs3212227, rs6887695) and the risk of AR using the polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP) method. Our results showed no significant association between IL12B rs3212227 A > C polymorphism with AR. In contrast, the GC genotype of rs6887695 G > C was associated with susceptibility to AR in comparison with the GG genotype (
p
= 0.049, OR = 1.684, 95% CI: 1.002–2.83). We also observed a statistically significant difference in the additive model (GC versus GG + CC,
p
= 0.03, OR = 1.705, 95% CI: 1.040–2.794) for SNPs rs6887695. Furthermore, haplotypes analysis demonstrated that C–C haplotype was associated with an increased risk of AR (
p
= 0.01, OR = 1.845, 95% CI: 1.114–3.057). Our findings suggest that IL12B rs6887695 polymorphism may be a potential biomarker for susceptibility to AR in an Iranian population. |
| doi_str_mv | 10.1007/s12026-021-09189-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2511238414</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2523913953</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-dd328ff2d249073d043b8e814ba1e19d07a7895e78069e67cd90efd29084a2003</originalsourceid><addsrcrecordid>eNp9kMtKBDEQRYMoOj5-wIU0uHETrcqjkyx18AWCCAruQk93WqM93WOSRvx7o-MDXLiqRZ17qziE7CIcIoA6isiAlRQYUjCoDcUVMkEpDQUl5SqZAJOKMqXuN8hmjE8AWArB18kG55oLrvWE3BzHONS-Sn7oi6EtfJ9c6Nz47HuK7KQIsdRalUYWrz49FnGMtVskP_OdT29FGoqq61x48HURHn3vk4_bZK2tuuh2vuYWuTs7vZ1e0Kvr88vp8RWtuZKJNg1num1Zw4QBxRsQfKadRjGr0KFpQFVKG-mUhtK4UtWNAdc2zIAWFQPgW-Rg2bsIw8voYrJzn5_ruqp3wxgtk4iMa4Eio_t_0KdhDH3-LlOMG-RG8kyxJVWHIcbgWrsIfl6FN4tgP4TbpXCbhdtP4RZzaO-repzNXfMT-TacAb4EYl71Dy783v6n9h0nuYlP</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2523913953</pqid></control><display><type>article</type><title>Association of interleukin-12B rs6887695 with susceptibility to allergic rhinitis</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Falahi, Sara ; Salari, Farhad ; Rezaiemanesh, Alireza ; Mortazavi, Seyed Hamidreza ; Koohyanizadeh, Farzaneh ; Lotfi, Ramin ; Gorgin Karaji, Ali</creator><creatorcontrib>Falahi, Sara ; Salari, Farhad ; Rezaiemanesh, Alireza ; Mortazavi, Seyed Hamidreza ; Koohyanizadeh, Farzaneh ; Lotfi, Ramin ; Gorgin Karaji, Ali</creatorcontrib><description>Interleukin-12 (IL-12) is a heterodimeric cytokine encoded by two separate genes, IL12A and IL12B, which may play a regulatory role in allergen-induced inflammation through CD4
+
T-cell subsets polarization. The aim of this study was to investigate the association of single-nucleotide polymorphisms (SNPs) in the IL12B gene with susceptibility to allergic rhinitis (AR). We performed a case–control study including 130 AR patients and 130 healthy controls to evaluate the possible association between IL12B gene SNPs (rs3212227, rs6887695) and the risk of AR using the polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP) method. Our results showed no significant association between IL12B rs3212227 A > C polymorphism with AR. In contrast, the GC genotype of rs6887695 G > C was associated with susceptibility to AR in comparison with the GG genotype (
p
= 0.049, OR = 1.684, 95% CI: 1.002–2.83). We also observed a statistically significant difference in the additive model (GC versus GG + CC,
p
= 0.03, OR = 1.705, 95% CI: 1.040–2.794) for SNPs rs6887695. Furthermore, haplotypes analysis demonstrated that C–C haplotype was associated with an increased risk of AR (
p
= 0.01, OR = 1.845, 95% CI: 1.114–3.057). Our findings suggest that IL12B rs6887695 polymorphism may be a potential biomarker for susceptibility to AR in an Iranian population.</description><identifier>ISSN: 0257-277X</identifier><identifier>EISSN: 1559-0755</identifier><identifier>DOI: 10.1007/s12026-021-09189-1</identifier><identifier>PMID: 33834388</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Allergens ; Allergic rhinitis ; Allergology ; Biomarkers ; Biomedical and Life Sciences ; Biomedicine ; Case-Control Studies ; CD4 antigen ; Cytokines ; Female ; Gene polymorphism ; Genetic Predisposition to Disease ; Genotype ; Haplotypes ; Humans ; IL12B protein ; Immunology ; Inflammation ; Interleukin 1 ; Interleukin 12 ; Interleukin-12 Subunit p40 - genetics ; Internal Medicine ; Iran ; Lymphocytes T ; Male ; Medicine/Public Health ; Middle Aged ; Nucleotides ; Original Article ; Polymerase chain reaction ; Polymorphism ; Polymorphism, Single Nucleotide ; Restriction fragment length polymorphism ; Rhinitis ; Rhinitis, Allergic - genetics ; Single-nucleotide polymorphism ; Statistical analysis ; Susceptibility</subject><ispartof>Immunologic research, 2021-04, Vol.69 (2), p.189-195</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-dd328ff2d249073d043b8e814ba1e19d07a7895e78069e67cd90efd29084a2003</citedby><cites>FETCH-LOGICAL-c375t-dd328ff2d249073d043b8e814ba1e19d07a7895e78069e67cd90efd29084a2003</cites><orcidid>0000-0003-4537-5722</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12026-021-09189-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12026-021-09189-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33834388$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Falahi, Sara</creatorcontrib><creatorcontrib>Salari, Farhad</creatorcontrib><creatorcontrib>Rezaiemanesh, Alireza</creatorcontrib><creatorcontrib>Mortazavi, Seyed Hamidreza</creatorcontrib><creatorcontrib>Koohyanizadeh, Farzaneh</creatorcontrib><creatorcontrib>Lotfi, Ramin</creatorcontrib><creatorcontrib>Gorgin Karaji, Ali</creatorcontrib><title>Association of interleukin-12B rs6887695 with susceptibility to allergic rhinitis</title><title>Immunologic research</title><addtitle>Immunol Res</addtitle><addtitle>Immunol Res</addtitle><description>Interleukin-12 (IL-12) is a heterodimeric cytokine encoded by two separate genes, IL12A and IL12B, which may play a regulatory role in allergen-induced inflammation through CD4
+
T-cell subsets polarization. The aim of this study was to investigate the association of single-nucleotide polymorphisms (SNPs) in the IL12B gene with susceptibility to allergic rhinitis (AR). We performed a case–control study including 130 AR patients and 130 healthy controls to evaluate the possible association between IL12B gene SNPs (rs3212227, rs6887695) and the risk of AR using the polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP) method. Our results showed no significant association between IL12B rs3212227 A > C polymorphism with AR. In contrast, the GC genotype of rs6887695 G > C was associated with susceptibility to AR in comparison with the GG genotype (
p
= 0.049, OR = 1.684, 95% CI: 1.002–2.83). We also observed a statistically significant difference in the additive model (GC versus GG + CC,
p
= 0.03, OR = 1.705, 95% CI: 1.040–2.794) for SNPs rs6887695. Furthermore, haplotypes analysis demonstrated that C–C haplotype was associated with an increased risk of AR (
p
= 0.01, OR = 1.845, 95% CI: 1.114–3.057). Our findings suggest that IL12B rs6887695 polymorphism may be a potential biomarker for susceptibility to AR in an Iranian population.</description><subject>Adult</subject><subject>Allergens</subject><subject>Allergic rhinitis</subject><subject>Allergology</subject><subject>Biomarkers</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Case-Control Studies</subject><subject>CD4 antigen</subject><subject>Cytokines</subject><subject>Female</subject><subject>Gene polymorphism</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Haplotypes</subject><subject>Humans</subject><subject>IL12B protein</subject><subject>Immunology</subject><subject>Inflammation</subject><subject>Interleukin 1</subject><subject>Interleukin 12</subject><subject>Interleukin-12 Subunit p40 - genetics</subject><subject>Internal Medicine</subject><subject>Iran</subject><subject>Lymphocytes T</subject><subject>Male</subject><subject>Medicine/Public Health</subject><subject>Middle Aged</subject><subject>Nucleotides</subject><subject>Original Article</subject><subject>Polymerase chain reaction</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Restriction fragment length polymorphism</subject><subject>Rhinitis</subject><subject>Rhinitis, Allergic - genetics</subject><subject>Single-nucleotide polymorphism</subject><subject>Statistical analysis</subject><subject>Susceptibility</subject><issn>0257-277X</issn><issn>1559-0755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kMtKBDEQRYMoOj5-wIU0uHETrcqjkyx18AWCCAruQk93WqM93WOSRvx7o-MDXLiqRZ17qziE7CIcIoA6isiAlRQYUjCoDcUVMkEpDQUl5SqZAJOKMqXuN8hmjE8AWArB18kG55oLrvWE3BzHONS-Sn7oi6EtfJ9c6Nz47HuK7KQIsdRalUYWrz49FnGMtVskP_OdT29FGoqq61x48HURHn3vk4_bZK2tuuh2vuYWuTs7vZ1e0Kvr88vp8RWtuZKJNg1num1Zw4QBxRsQfKadRjGr0KFpQFVKG-mUhtK4UtWNAdc2zIAWFQPgW-Rg2bsIw8voYrJzn5_ruqp3wxgtk4iMa4Eio_t_0KdhDH3-LlOMG-RG8kyxJVWHIcbgWrsIfl6FN4tgP4TbpXCbhdtP4RZzaO-repzNXfMT-TacAb4EYl71Dy783v6n9h0nuYlP</recordid><startdate>20210401</startdate><enddate>20210401</enddate><creator>Falahi, Sara</creator><creator>Salari, Farhad</creator><creator>Rezaiemanesh, Alireza</creator><creator>Mortazavi, Seyed Hamidreza</creator><creator>Koohyanizadeh, Farzaneh</creator><creator>Lotfi, Ramin</creator><creator>Gorgin Karaji, Ali</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4537-5722</orcidid></search><sort><creationdate>20210401</creationdate><title>Association of interleukin-12B rs6887695 with susceptibility to allergic rhinitis</title><author>Falahi, Sara ; Salari, Farhad ; Rezaiemanesh, Alireza ; Mortazavi, Seyed Hamidreza ; Koohyanizadeh, Farzaneh ; Lotfi, Ramin ; Gorgin Karaji, Ali</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-dd328ff2d249073d043b8e814ba1e19d07a7895e78069e67cd90efd29084a2003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Allergens</topic><topic>Allergic rhinitis</topic><topic>Allergology</topic><topic>Biomarkers</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Case-Control Studies</topic><topic>CD4 antigen</topic><topic>Cytokines</topic><topic>Female</topic><topic>Gene polymorphism</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Haplotypes</topic><topic>Humans</topic><topic>IL12B protein</topic><topic>Immunology</topic><topic>Inflammation</topic><topic>Interleukin 1</topic><topic>Interleukin 12</topic><topic>Interleukin-12 Subunit p40 - genetics</topic><topic>Internal Medicine</topic><topic>Iran</topic><topic>Lymphocytes T</topic><topic>Male</topic><topic>Medicine/Public Health</topic><topic>Middle Aged</topic><topic>Nucleotides</topic><topic>Original Article</topic><topic>Polymerase chain reaction</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Restriction fragment length polymorphism</topic><topic>Rhinitis</topic><topic>Rhinitis, Allergic - genetics</topic><topic>Single-nucleotide polymorphism</topic><topic>Statistical analysis</topic><topic>Susceptibility</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Falahi, Sara</creatorcontrib><creatorcontrib>Salari, Farhad</creatorcontrib><creatorcontrib>Rezaiemanesh, Alireza</creatorcontrib><creatorcontrib>Mortazavi, Seyed Hamidreza</creatorcontrib><creatorcontrib>Koohyanizadeh, Farzaneh</creatorcontrib><creatorcontrib>Lotfi, Ramin</creatorcontrib><creatorcontrib>Gorgin Karaji, Ali</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Immunologic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Falahi, Sara</au><au>Salari, Farhad</au><au>Rezaiemanesh, Alireza</au><au>Mortazavi, Seyed Hamidreza</au><au>Koohyanizadeh, Farzaneh</au><au>Lotfi, Ramin</au><au>Gorgin Karaji, Ali</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of interleukin-12B rs6887695 with susceptibility to allergic rhinitis</atitle><jtitle>Immunologic research</jtitle><stitle>Immunol Res</stitle><addtitle>Immunol Res</addtitle><date>2021-04-01</date><risdate>2021</risdate><volume>69</volume><issue>2</issue><spage>189</spage><epage>195</epage><pages>189-195</pages><issn>0257-277X</issn><eissn>1559-0755</eissn><abstract>Interleukin-12 (IL-12) is a heterodimeric cytokine encoded by two separate genes, IL12A and IL12B, which may play a regulatory role in allergen-induced inflammation through CD4
+
T-cell subsets polarization. The aim of this study was to investigate the association of single-nucleotide polymorphisms (SNPs) in the IL12B gene with susceptibility to allergic rhinitis (AR). We performed a case–control study including 130 AR patients and 130 healthy controls to evaluate the possible association between IL12B gene SNPs (rs3212227, rs6887695) and the risk of AR using the polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP) method. Our results showed no significant association between IL12B rs3212227 A > C polymorphism with AR. In contrast, the GC genotype of rs6887695 G > C was associated with susceptibility to AR in comparison with the GG genotype (
p
= 0.049, OR = 1.684, 95% CI: 1.002–2.83). We also observed a statistically significant difference in the additive model (GC versus GG + CC,
p
= 0.03, OR = 1.705, 95% CI: 1.040–2.794) for SNPs rs6887695. Furthermore, haplotypes analysis demonstrated that C–C haplotype was associated with an increased risk of AR (
p
= 0.01, OR = 1.845, 95% CI: 1.114–3.057). Our findings suggest that IL12B rs6887695 polymorphism may be a potential biomarker for susceptibility to AR in an Iranian population.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>33834388</pmid><doi>10.1007/s12026-021-09189-1</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-4537-5722</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0257-277X |
| ispartof | Immunologic research, 2021-04, Vol.69 (2), p.189-195 |
| issn | 0257-277X 1559-0755 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2511238414 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Allergens Allergic rhinitis Allergology Biomarkers Biomedical and Life Sciences Biomedicine Case-Control Studies CD4 antigen Cytokines Female Gene polymorphism Genetic Predisposition to Disease Genotype Haplotypes Humans IL12B protein Immunology Inflammation Interleukin 1 Interleukin 12 Interleukin-12 Subunit p40 - genetics Internal Medicine Iran Lymphocytes T Male Medicine/Public Health Middle Aged Nucleotides Original Article Polymerase chain reaction Polymorphism Polymorphism, Single Nucleotide Restriction fragment length polymorphism Rhinitis Rhinitis, Allergic - genetics Single-nucleotide polymorphism Statistical analysis Susceptibility |
| title | Association of interleukin-12B rs6887695 with susceptibility to allergic rhinitis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T07%3A02%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20of%20interleukin-12B%20rs6887695%20with%20susceptibility%20to%20allergic%20rhinitis&rft.jtitle=Immunologic%20research&rft.au=Falahi,%20Sara&rft.date=2021-04-01&rft.volume=69&rft.issue=2&rft.spage=189&rft.epage=195&rft.pages=189-195&rft.issn=0257-277X&rft.eissn=1559-0755&rft_id=info:doi/10.1007/s12026-021-09189-1&rft_dat=%3Cproquest_cross%3E2523913953%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2523913953&rft_id=info:pmid/33834388&rfr_iscdi=true |