Multidimensional flow cytometry reveals novel platelet subpopulations in response to prostacyclin

Background Robust platelet activation leads to the generation of subpopulations characterized by differential expression of phosphatidylserine (PS). Prostacyclin (PGI2) modulates many aspects of platelet function, but its influence on platelet subpopulations is unknown. Objectives and Methods We use...

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Veröffentlicht in:	Journal of thrombosis and haemostasis 2021-07, Vol.19 (7), p.1800-1812
Hauptverfasser:	Hindle, Matthew S., Spurgeon, Benjamin E. J., Cheah, Lih T., Webb, Beth A., Naseem, Khalid M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood platelets cAMP CD40L protein CD63 antigen Computer applications Cyclic AMP Depolarization Embedding Fibrinogen Flow cytometry Fourier analysis Fourier transforms Mitochondria Monocytes Phosphatidylserine Phosphorylation Platelets procoagulant Prostacyclin subpopulations
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