Yeasts as a promising delivery platform for DNA and RNA vaccines
ABSTRACT Yeasts are considered a useful system for the development of vaccines for human and veterinary health. Species such as Saccharomyces cerevisiae and Pichia pastoris have been used successfully as host organisms for the production of subunit vaccines. These organisms have been also explored a...
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| Veröffentlicht in: | FEMS yeast research 2021-05, Vol.21 (3), p.1 |
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| creator | Silva, Anna Jéssica Duarte de Macêdo, Larissa Silva Leal, Lígia Rosa Sales de Jesus, André Luiz Santos Freitas, Antonio Carlos |
| description | ABSTRACT
Yeasts are considered a useful system for the development of vaccines for human and veterinary health. Species such as Saccharomyces cerevisiae and Pichia pastoris have been used successfully as host organisms for the production of subunit vaccines. These organisms have been also explored as vaccine vehicles enabling the delivery of antigens such as proteins and nucleic acids. The employed species possess a GRAS status (Generally Recognized as Safe) for the production of therapeutic proteins, besides promoting immunostimulation due to the properties of their wall cell composition. This strategy allows the administration of nucleic acids orally and a specific delivery to professional antigen-presenting cells (APCs). In this review, we seek to outline the development of whole yeast vaccines (WYV) carrying nucleic acids in different approaches in the medical field, as well as the immunological aspects of this vaccine strategy. The data presented here reveal the application of this platform in promoting effective immune responses in the context of prophylactic and therapeutic approaches.
Yeasts have the potential to be used as vaccine vehicles, carrying nucleic acids in immunotherapy strategies. |
| doi_str_mv | 10.1093/femsyr/foab018 |
| format | Article |
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Yeasts are considered a useful system for the development of vaccines for human and veterinary health. Species such as Saccharomyces cerevisiae and Pichia pastoris have been used successfully as host organisms for the production of subunit vaccines. These organisms have been also explored as vaccine vehicles enabling the delivery of antigens such as proteins and nucleic acids. The employed species possess a GRAS status (Generally Recognized as Safe) for the production of therapeutic proteins, besides promoting immunostimulation due to the properties of their wall cell composition. This strategy allows the administration of nucleic acids orally and a specific delivery to professional antigen-presenting cells (APCs). In this review, we seek to outline the development of whole yeast vaccines (WYV) carrying nucleic acids in different approaches in the medical field, as well as the immunological aspects of this vaccine strategy. The data presented here reveal the application of this platform in promoting effective immune responses in the context of prophylactic and therapeutic approaches.
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Yeasts are considered a useful system for the development of vaccines for human and veterinary health. Species such as Saccharomyces cerevisiae and Pichia pastoris have been used successfully as host organisms for the production of subunit vaccines. These organisms have been also explored as vaccine vehicles enabling the delivery of antigens such as proteins and nucleic acids. The employed species possess a GRAS status (Generally Recognized as Safe) for the production of therapeutic proteins, besides promoting immunostimulation due to the properties of their wall cell composition. This strategy allows the administration of nucleic acids orally and a specific delivery to professional antigen-presenting cells (APCs). In this review, we seek to outline the development of whole yeast vaccines (WYV) carrying nucleic acids in different approaches in the medical field, as well as the immunological aspects of this vaccine strategy. The data presented here reveal the application of this platform in promoting effective immune responses in the context of prophylactic and therapeutic approaches.
Yeasts have the potential to be used as vaccine vehicles, carrying nucleic acids in immunotherapy strategies.</description><subject>Antigen-presenting cells</subject><subject>Antigens</subject><subject>DNA</subject><subject>DNA vaccines</subject><subject>Drug Delivery Systems</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immunostimulation</subject><subject>Immunotherapy</subject><subject>mRNA Vaccines</subject><subject>Proteins</subject><subject>RNA</subject><subject>Saccharomyces cerevisiae - genetics</subject><subject>Saccharomycetales - genetics</subject><subject>Vaccines</subject><subject>Vaccines, DNA - administration & dosage</subject><subject>Vaccines, DNA - genetics</subject><subject>Vaccines, Subunit</subject><subject>Vaccines, Synthetic - administration & dosage</subject><subject>Vaccines, Synthetic - genetics</subject><subject>Yeast</subject><subject>Yeasts - genetics</subject><issn>1567-1356</issn><issn>1567-1364</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkU1LAzEQhoMoflSvHmXBix5aM5vd7uZmqV8FUah68BSyyaSs7G5qsiv235tirSiCJGTC8MybybyEHAIdAOXszGDtF-7MWFlQyDfILqTDrA9smGyu7-lwh-x5_0IpZJTm22SHsZxlWZ7ukvNnlL71kQw7mjtbl75sZpHGqnxDt4jmlWyNdXUUjujibhTJRkfTEN-kUmWDfp9sGVl5PFjFHnm6unwc3_Rv768n49FtXyU8b_s8STXTLNGoMpCxzkOaogHKDJeF5kmOOIyBa61iCQawkFolGjjVHIsUWI-cfOqGJl879K0IrSqsKtmg7byIU4CYZXk4euT4F_piO9eE7gLFIOZhEPSbmskKRdkY2zqplqJilNHl6MKsAjX4gwpLY10q26ApQ_5HwemPgsC0-N7OZOe9mDxM_xRXznrv0Ii5K2vpFgKoWNorPu0VK3tDwdHqZ11Ro17jX35-v267-X9iH98krWQ</recordid><startdate>20210501</startdate><enddate>20210501</enddate><creator>Silva, Anna Jéssica Duarte</creator><creator>de Macêdo, Larissa Silva</creator><creator>Leal, Lígia Rosa Sales</creator><creator>de Jesus, André Luiz Santos</creator><creator>Freitas, Antonio Carlos</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4957-9549</orcidid><orcidid>https://orcid.org/0000-0003-2335-5712</orcidid></search><sort><creationdate>20210501</creationdate><title>Yeasts as a promising delivery platform for DNA and RNA vaccines</title><author>Silva, Anna Jéssica Duarte ; 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Yeasts are considered a useful system for the development of vaccines for human and veterinary health. Species such as Saccharomyces cerevisiae and Pichia pastoris have been used successfully as host organisms for the production of subunit vaccines. These organisms have been also explored as vaccine vehicles enabling the delivery of antigens such as proteins and nucleic acids. The employed species possess a GRAS status (Generally Recognized as Safe) for the production of therapeutic proteins, besides promoting immunostimulation due to the properties of their wall cell composition. This strategy allows the administration of nucleic acids orally and a specific delivery to professional antigen-presenting cells (APCs). In this review, we seek to outline the development of whole yeast vaccines (WYV) carrying nucleic acids in different approaches in the medical field, as well as the immunological aspects of this vaccine strategy. The data presented here reveal the application of this platform in promoting effective immune responses in the context of prophylactic and therapeutic approaches.
Yeasts have the potential to be used as vaccine vehicles, carrying nucleic acids in immunotherapy strategies.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>33837785</pmid><doi>10.1093/femsyr/foab018</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-4957-9549</orcidid><orcidid>https://orcid.org/0000-0003-2335-5712</orcidid><oa>free_for_read</oa></addata></record> |
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| issn | 1567-1356 1567-1364 |
| language | eng |
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| source | Oxford Journals Open Access Collection |
| subjects | Antigen-presenting cells Antigens DNA DNA vaccines Drug Delivery Systems Health aspects Humans Immune response Immunostimulation Immunotherapy mRNA Vaccines Proteins RNA Saccharomyces cerevisiae - genetics Saccharomycetales - genetics Vaccines Vaccines, DNA - administration & dosage Vaccines, DNA - genetics Vaccines, Subunit Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - genetics Yeast Yeasts - genetics |
| title | Yeasts as a promising delivery platform for DNA and RNA vaccines |
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