Discovery of novel pyrimidine molecules containing boronic acid as VCP/p97 Inhibitors

[Display omitted] Valine-containing protein (VCP) is a member of the adenosine triphosphate family involved in a variety of cellular activities. VCP/p97 is capable of maintaining protein homeostasis and mediating the degradation of misfolded polypeptides by the ubiquitin–proteasome system (UPS). In...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2021-05, Vol.38, p.116114-116114, Article 116114
Hauptverfasser:	Zhang, Yonglei, Xie, Xiaomin, Wang, Xueyuan, Wen, Tiantian, Zhao, Chi, Liu, Hailong, Zhao, Bo, Zhu, Yongqiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological activity Boric acid Molecular docking Ubiquitin–proteasome system Valine-containing protein
Online-Zugang:	Volltext
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