Transcription factor SP1-induced microRNA-146b-3p facilitates the progression and metastasis of colorectal cancer via regulating FAM107A

Recent studies have provided compelling evidence regarding the association of microRNAs (miRNAs) with the progression and development of tumors. Among the miRNAs, the dysregulation of miR-146b-3p expression has been reported in several cancers, however, its effect on colorectal cancer (CRC) remains...

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Veröffentlicht in:	Life sciences (1973) 2021-07, Vol.277, p.119398-119398, Article 119398
Hauptverfasser:	Wang, Di, Feng, Meina, Ma, Xianxiong, Tao, Kaixiong, Wang, Guobin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animals Apoptosis Apoptosis - genetics ArrayExpress Assaying Cancer Cell cycle Cell Cycle - genetics Cell growth Cell Line, Tumor Cell migration Cell Movement - genetics Cell proliferation Cell Proliferation - drug effects Chromatin Colorectal Cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Downstream effects FAM107A Female Flow cytometry Gene Expression Regulation, Neoplastic - genetics Genes, Tumor Suppressor - physiology GEO Humans Immunoprecipitation Male Metastases Mice Mice, Inbred BALB C MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Middle Aged MiR-146b-3p miRNA Neoplasm Metastasis - genetics Nuclear Proteins - genetics Nuclear Proteins - metabolism Polymerase chain reaction Ribonucleic acid RNA SP1 Sp1 Transcription Factor - genetics Sp1 Transcription Factor - metabolism Transcription factors Tumors Western blotting Xenograft Model Antitumor Assays
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