Presence of risk factors for thyroid cancer does not improve the performance of ultrasound screening for thyroid nodules in patients with obesity
Purpose It has been suggested, on a theoretical basis, that ultrasound screening of thyroid nodules in obese patients with additional risk factors (family history, chronic autoimmune thyroiditis or high thyrotropin) might be cost‐effective for the early detection and treatment of thyroid cancer. The...
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| Veröffentlicht in: | International journal of clinical practice (Esher) 2021-07, Vol.75 (7), p.e14211-n/a |
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| container_title | International journal of clinical practice (Esher) |
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| creator | Gimenez‐Perez, Gabriel Recasens, Assumpta Chicharro, Sandra Simo, Olga Murillo, Jesus Castells, Ignasi |
| description | Purpose
It has been suggested, on a theoretical basis, that ultrasound screening of thyroid nodules in obese patients with additional risk factors (family history, chronic autoimmune thyroiditis or high thyrotropin) might be cost‐effective for the early detection and treatment of thyroid cancer. The present study evaluates if this approach can be validated in a real clinical setting.
Methods
Patients with obesity who attended hospital‐based clinics were evaluated for risk factors of thyroid cancer and ultrasound screened for thyroid nodularity. Detected nodules were evaluated according to current guidelines.
Results
A total of 429 patients were evaluated (70.2% women, mean age 49.1 ± 11.0, mean body mass index 42.6 ± 5.8 kg/m2). Risk factors were present in 129 (30.1%) patients. Thyroid nodules with indication for fine‐needle aspiration biopsy were detected in 69 (16.1%). We did not find differences in the risk of harbouring thyroid nodules according to the presence of risk factors (no risk factors 16.6%, risk factors 14.1%, P = .64). No single risk factor conferred an increased risk for thyroid nodules During the screening procedure, four cases of thyroid cancer were detected, none of them with the evaluated risk factors.
Conclusion
The presence of known risk factors for thyroid cancer does not improve the performance of a US screening strategy aimed at the detection of thyroid nodules in obese patients. According to current guidelines, screening for thyroid nodules in obese patients is not recommended regardless of the presence of thyroid cancer risk factors. |
| doi_str_mv | 10.1111/ijcp.14211 |
| format | Article |
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It has been suggested, on a theoretical basis, that ultrasound screening of thyroid nodules in obese patients with additional risk factors (family history, chronic autoimmune thyroiditis or high thyrotropin) might be cost‐effective for the early detection and treatment of thyroid cancer. The present study evaluates if this approach can be validated in a real clinical setting.
Methods
Patients with obesity who attended hospital‐based clinics were evaluated for risk factors of thyroid cancer and ultrasound screened for thyroid nodularity. Detected nodules were evaluated according to current guidelines.
Results
A total of 429 patients were evaluated (70.2% women, mean age 49.1 ± 11.0, mean body mass index 42.6 ± 5.8 kg/m2). Risk factors were present in 129 (30.1%) patients. Thyroid nodules with indication for fine‐needle aspiration biopsy were detected in 69 (16.1%). We did not find differences in the risk of harbouring thyroid nodules according to the presence of risk factors (no risk factors 16.6%, risk factors 14.1%, P = .64). No single risk factor conferred an increased risk for thyroid nodules During the screening procedure, four cases of thyroid cancer were detected, none of them with the evaluated risk factors.
Conclusion
The presence of known risk factors for thyroid cancer does not improve the performance of a US screening strategy aimed at the detection of thyroid nodules in obese patients. According to current guidelines, screening for thyroid nodules in obese patients is not recommended regardless of the presence of thyroid cancer risk factors.</description><identifier>ISSN: 1368-5031</identifier><identifier>EISSN: 1742-1241</identifier><identifier>DOI: 10.1111/ijcp.14211</identifier><identifier>PMID: 33826764</identifier><language>eng</language><publisher>England: Hindawi Limited</publisher><subject>Biopsy ; Body mass index ; Nodules ; Obesity ; Patients ; Risk factors ; Thyroid cancer ; Thyroid-stimulating hormone ; Thyroiditis ; Ultrasonic imaging ; Ultrasound</subject><ispartof>International journal of clinical practice (Esher), 2021-07, Vol.75 (7), p.e14211-n/a</ispartof><rights>2021 John Wiley & Sons Ltd</rights><rights>2021 John Wiley & Sons Ltd.</rights><rights>Copyright © 2021 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3931-e9d6f5ec2181ce5e110b79384d3cc69fa52ccc27231639cf4cd69377186510bf3</citedby><cites>FETCH-LOGICAL-c3931-e9d6f5ec2181ce5e110b79384d3cc69fa52ccc27231639cf4cd69377186510bf3</cites><orcidid>0000-0002-8541-766X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fijcp.14211$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fijcp.14211$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33826764$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gimenez‐Perez, Gabriel</creatorcontrib><creatorcontrib>Recasens, Assumpta</creatorcontrib><creatorcontrib>Chicharro, Sandra</creatorcontrib><creatorcontrib>Simo, Olga</creatorcontrib><creatorcontrib>Murillo, Jesus</creatorcontrib><creatorcontrib>Castells, Ignasi</creatorcontrib><title>Presence of risk factors for thyroid cancer does not improve the performance of ultrasound screening for thyroid nodules in patients with obesity</title><title>International journal of clinical practice (Esher)</title><addtitle>Int J Clin Pract</addtitle><description>Purpose
It has been suggested, on a theoretical basis, that ultrasound screening of thyroid nodules in obese patients with additional risk factors (family history, chronic autoimmune thyroiditis or high thyrotropin) might be cost‐effective for the early detection and treatment of thyroid cancer. The present study evaluates if this approach can be validated in a real clinical setting.
Methods
Patients with obesity who attended hospital‐based clinics were evaluated for risk factors of thyroid cancer and ultrasound screened for thyroid nodularity. Detected nodules were evaluated according to current guidelines.
Results
A total of 429 patients were evaluated (70.2% women, mean age 49.1 ± 11.0, mean body mass index 42.6 ± 5.8 kg/m2). Risk factors were present in 129 (30.1%) patients. Thyroid nodules with indication for fine‐needle aspiration biopsy were detected in 69 (16.1%). We did not find differences in the risk of harbouring thyroid nodules according to the presence of risk factors (no risk factors 16.6%, risk factors 14.1%, P = .64). No single risk factor conferred an increased risk for thyroid nodules During the screening procedure, four cases of thyroid cancer were detected, none of them with the evaluated risk factors.
Conclusion
The presence of known risk factors for thyroid cancer does not improve the performance of a US screening strategy aimed at the detection of thyroid nodules in obese patients. According to current guidelines, screening for thyroid nodules in obese patients is not recommended regardless of the presence of thyroid cancer risk factors.</description><subject>Biopsy</subject><subject>Body mass index</subject><subject>Nodules</subject><subject>Obesity</subject><subject>Patients</subject><subject>Risk factors</subject><subject>Thyroid cancer</subject><subject>Thyroid-stimulating hormone</subject><subject>Thyroiditis</subject><subject>Ultrasonic imaging</subject><subject>Ultrasound</subject><issn>1368-5031</issn><issn>1742-1241</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp90c-L1DAUwPEgiruuXvwDJOBFhK59SZq2Rxn8sbLgHvRcMq8vbsY2qUnqMn-G_7EZZxT0YC4J5MOXhMfYU6gvoaxXbofLJSgBcI-dQ6tEBULB_XKWuquaWsIZe5TSrq5F03T1Q3YmZSd0q9U5-3ETKZFH4sHy6NJXbg3mEBO3IfJ8u4_BjRxNEZGPgRL3IXM3LzF8p3JPfKFY6GxOjXXK0aSw-pEnjETe-S9_tXwY16l0nOeLyY58TvzO5VsetpRc3j9mD6yZEj057Rfs89s3nzbvq-uP7642r68rlL2EivpR24ZQQAdIDQHU27aXnRolou6taQQiilZI0LJHq3DUvWxb6HRTqJUX7MWxW77ybaWUh9klpGkynsKaBlGY0FooVejzf-gurNGX1xWlula1tT6ol0eFMaQUyQ5LdLOJ-wHq4TCo4TCo4degCn52Sq7bmcY_9PdkCoAjuHMT7f-TGq4-bG6O0Z_vN6AA</recordid><startdate>202107</startdate><enddate>202107</enddate><creator>Gimenez‐Perez, Gabriel</creator><creator>Recasens, Assumpta</creator><creator>Chicharro, Sandra</creator><creator>Simo, Olga</creator><creator>Murillo, Jesus</creator><creator>Castells, Ignasi</creator><general>Hindawi Limited</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8541-766X</orcidid></search><sort><creationdate>202107</creationdate><title>Presence of risk factors for thyroid cancer does not improve the performance of ultrasound screening for thyroid nodules in patients with obesity</title><author>Gimenez‐Perez, Gabriel ; Recasens, Assumpta ; Chicharro, Sandra ; Simo, Olga ; Murillo, Jesus ; Castells, Ignasi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3931-e9d6f5ec2181ce5e110b79384d3cc69fa52ccc27231639cf4cd69377186510bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Biopsy</topic><topic>Body mass index</topic><topic>Nodules</topic><topic>Obesity</topic><topic>Patients</topic><topic>Risk factors</topic><topic>Thyroid cancer</topic><topic>Thyroid-stimulating hormone</topic><topic>Thyroiditis</topic><topic>Ultrasonic imaging</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gimenez‐Perez, Gabriel</creatorcontrib><creatorcontrib>Recasens, Assumpta</creatorcontrib><creatorcontrib>Chicharro, Sandra</creatorcontrib><creatorcontrib>Simo, Olga</creatorcontrib><creatorcontrib>Murillo, Jesus</creatorcontrib><creatorcontrib>Castells, Ignasi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of clinical practice (Esher)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gimenez‐Perez, Gabriel</au><au>Recasens, Assumpta</au><au>Chicharro, Sandra</au><au>Simo, Olga</au><au>Murillo, Jesus</au><au>Castells, Ignasi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Presence of risk factors for thyroid cancer does not improve the performance of ultrasound screening for thyroid nodules in patients with obesity</atitle><jtitle>International journal of clinical practice (Esher)</jtitle><addtitle>Int J Clin Pract</addtitle><date>2021-07</date><risdate>2021</risdate><volume>75</volume><issue>7</issue><spage>e14211</spage><epage>n/a</epage><pages>e14211-n/a</pages><issn>1368-5031</issn><eissn>1742-1241</eissn><abstract>Purpose
It has been suggested, on a theoretical basis, that ultrasound screening of thyroid nodules in obese patients with additional risk factors (family history, chronic autoimmune thyroiditis or high thyrotropin) might be cost‐effective for the early detection and treatment of thyroid cancer. The present study evaluates if this approach can be validated in a real clinical setting.
Methods
Patients with obesity who attended hospital‐based clinics were evaluated for risk factors of thyroid cancer and ultrasound screened for thyroid nodularity. Detected nodules were evaluated according to current guidelines.
Results
A total of 429 patients were evaluated (70.2% women, mean age 49.1 ± 11.0, mean body mass index 42.6 ± 5.8 kg/m2). Risk factors were present in 129 (30.1%) patients. Thyroid nodules with indication for fine‐needle aspiration biopsy were detected in 69 (16.1%). We did not find differences in the risk of harbouring thyroid nodules according to the presence of risk factors (no risk factors 16.6%, risk factors 14.1%, P = .64). No single risk factor conferred an increased risk for thyroid nodules During the screening procedure, four cases of thyroid cancer were detected, none of them with the evaluated risk factors.
Conclusion
The presence of known risk factors for thyroid cancer does not improve the performance of a US screening strategy aimed at the detection of thyroid nodules in obese patients. According to current guidelines, screening for thyroid nodules in obese patients is not recommended regardless of the presence of thyroid cancer risk factors.</abstract><cop>England</cop><pub>Hindawi Limited</pub><pmid>33826764</pmid><doi>10.1111/ijcp.14211</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-8541-766X</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of clinical practice (Esher), 2021-07, Vol.75 (7), p.e14211-n/a |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Biopsy Body mass index Nodules Obesity Patients Risk factors Thyroid cancer Thyroid-stimulating hormone Thyroiditis Ultrasonic imaging Ultrasound |
| title | Presence of risk factors for thyroid cancer does not improve the performance of ultrasound screening for thyroid nodules in patients with obesity |
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