Structural insights into the ligand recognition and catalysis of the key aminobutanoyltransferase CntL in staphylopine biosynthesis

Staphylopine (StP) and other nicotianamine‐like metallophores are crucial for many pathogens to acquire the transition metals from hosts during invasion. CntL from Staphylococcus aureus (SaCntL) catalyzes the condensation of the 2‐aminobutyrate (Ab) moiety of S‐adenosylmethionine (SAM) with D‐histid...

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Veröffentlicht in:	The FASEB journal 2021-05, Vol.35 (5), p.e21575-n/a
Hauptverfasser:	Luo, Zhiteng, Luo, Siting, Ju, Yingchen, Ding, Peng, Xu, Jun, Gu, Qiong, Zhou, Huihao
Format:	Artikel
Sprache:	eng
Schlagworte:	biosynthesis metallophore Staphylococcus aureus substrate selectivity X‐ray crystallography
Online-Zugang:	Volltext
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