Identification, Characterization, and Suppression of Side Products Formed during the Synthesis of [177Lu]Lu-PSMA-617

In recent years, radiolabeled tracers targeting prostate-specific membrane antigen (PSMA) have had a tremendous impact on prostate cancer management. Here, we report on the formation of radioactive impurities formed during the clinical production of 177Lu-labeled PSMA-617. We provide compelling evid...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of medicinal chemistry 2021-04, Vol.64 (8), p.4960-4971
Hauptverfasser:	Martin, Sebastian, Tönnesmann, Roswitha, Hierlmeier, Ina, Maus, Stephan, Rosar, Florian, Ruf, Juri, Holland, Jason P, Ezziddin, Samer, Bartholomä, Mark D
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!