Lack of association between TREM2 rs75932628 variant and amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a multifactorial neurodegenerative disease. Inflammatory processes are among the mechanisms that are implicated in ALS pathogenesis. The TREM2 rs75932628 T variant may influence the regulatory effect of TREM2 on inflammation. Studies regarding the role of the r...
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| Veröffentlicht in: | Molecular biology reports 2021-03, Vol.48 (3), p.2601-2610 |
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| creator | Siokas, Vasileios Aloizou, Athina-Maria Liampas, Ioannis Tsouris, Zisis Mentis, Alexios-Fotios A. Nasios, Grigorios Papadimitriou, Dimitra Bogdanos, Dimitrios P. Hadjigeorgiou, Georgios M. Dardiotis, Efthimios |
| description | Amyotrophic lateral sclerosis (ALS) is a multifactorial neurodegenerative disease. Inflammatory processes are among the mechanisms that are implicated in ALS pathogenesis. The TREM2 rs75932628 T variant may influence the regulatory effect of TREM2 on inflammation. Studies regarding the role of the rs75932628 variant in ALS have yielded inconsistent results, so far. To assess the role of TREM2 rs75932628 on ALS risk. We genotyped 155 patients with sporadic ALS and 155 healthy controls for TREM2 rs75932628. We also merged and meta-analyzed our data with data from previous studies (with a total of 7524 ALS cases and 14,675 controls), regarding TREM2 rs75932628 and ALS. No ALS or healthy subjects carried the TREM2 rs75932628-T variant. Results from meta-analyses (overall approach and sensitivity analyses) yielded no significant results for possible connection between TREM2 rs75932628-T variant and ALS. Based on our results, TREM2 rs75932628 does not seem to play a determining role to the pathophysiology of ALS. |
| doi_str_mv | 10.1007/s11033-021-06312-1 |
| format | Article |
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Inflammatory processes are among the mechanisms that are implicated in ALS pathogenesis. The TREM2 rs75932628 T variant may influence the regulatory effect of TREM2 on inflammation. Studies regarding the role of the rs75932628 variant in ALS have yielded inconsistent results, so far. To assess the role of TREM2 rs75932628 on ALS risk. We genotyped 155 patients with sporadic ALS and 155 healthy controls for TREM2 rs75932628. We also merged and meta-analyzed our data with data from previous studies (with a total of 7524 ALS cases and 14,675 controls), regarding TREM2 rs75932628 and ALS. No ALS or healthy subjects carried the TREM2 rs75932628-T variant. Results from meta-analyses (overall approach and sensitivity analyses) yielded no significant results for possible connection between TREM2 rs75932628-T variant and ALS. Based on our results, TREM2 rs75932628 does not seem to play a determining role to the pathophysiology of ALS.</description><identifier>ISSN: 0301-4851</identifier><identifier>EISSN: 1573-4978</identifier><identifier>DOI: 10.1007/s11033-021-06312-1</identifier><identifier>PMID: 33826063</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Amyotrophic lateral sclerosis ; Amyotrophic Lateral Sclerosis - genetics ; Animal Anatomy ; Animal Biochemistry ; Biomedical and Life Sciences ; Cohort Studies ; Female ; Genetic Association Studies ; Genetic Predisposition to Disease ; Histology ; Humans ; Life Sciences ; Male ; Membrane Glycoproteins - genetics ; Meta-Analysis as Topic ; Middle Aged ; Morphology ; Neurodegenerative diseases ; Original Article ; Pathogenesis ; Polymorphism, Single Nucleotide - genetics ; Publication Bias ; Receptors, Immunologic - genetics ; Sensitivity analysis</subject><ispartof>Molecular biology reports, 2021-03, Vol.48 (3), p.2601-2610</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2021</rights><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-56b94fe211573f9d66cef69f732969d0eb6f3e357b4ef11f413b2f62eb976b003</citedby><cites>FETCH-LOGICAL-c375t-56b94fe211573f9d66cef69f732969d0eb6f3e357b4ef11f413b2f62eb976b003</cites><orcidid>0000-0003-2957-641X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11033-021-06312-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11033-021-06312-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33826063$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Siokas, Vasileios</creatorcontrib><creatorcontrib>Aloizou, Athina-Maria</creatorcontrib><creatorcontrib>Liampas, Ioannis</creatorcontrib><creatorcontrib>Tsouris, Zisis</creatorcontrib><creatorcontrib>Mentis, Alexios-Fotios A.</creatorcontrib><creatorcontrib>Nasios, Grigorios</creatorcontrib><creatorcontrib>Papadimitriou, Dimitra</creatorcontrib><creatorcontrib>Bogdanos, Dimitrios P.</creatorcontrib><creatorcontrib>Hadjigeorgiou, Georgios M.</creatorcontrib><creatorcontrib>Dardiotis, Efthimios</creatorcontrib><title>Lack of association between TREM2 rs75932628 variant and amyotrophic lateral sclerosis</title><title>Molecular biology reports</title><addtitle>Mol Biol Rep</addtitle><addtitle>Mol Biol Rep</addtitle><description>Amyotrophic lateral sclerosis (ALS) is a multifactorial neurodegenerative disease. Inflammatory processes are among the mechanisms that are implicated in ALS pathogenesis. The TREM2 rs75932628 T variant may influence the regulatory effect of TREM2 on inflammation. Studies regarding the role of the rs75932628 variant in ALS have yielded inconsistent results, so far. To assess the role of TREM2 rs75932628 on ALS risk. We genotyped 155 patients with sporadic ALS and 155 healthy controls for TREM2 rs75932628. We also merged and meta-analyzed our data with data from previous studies (with a total of 7524 ALS cases and 14,675 controls), regarding TREM2 rs75932628 and ALS. No ALS or healthy subjects carried the TREM2 rs75932628-T variant. Results from meta-analyses (overall approach and sensitivity analyses) yielded no significant results for possible connection between TREM2 rs75932628-T variant and ALS. Based on our results, TREM2 rs75932628 does not seem to play a determining role to the pathophysiology of ALS.</description><subject>Amyotrophic lateral sclerosis</subject><subject>Amyotrophic Lateral Sclerosis - genetics</subject><subject>Animal Anatomy</subject><subject>Animal Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Histology</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Membrane Glycoproteins - genetics</subject><subject>Meta-Analysis as Topic</subject><subject>Middle Aged</subject><subject>Morphology</subject><subject>Neurodegenerative diseases</subject><subject>Original Article</subject><subject>Pathogenesis</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Publication Bias</subject><subject>Receptors, Immunologic - 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Academic</collection><jtitle>Molecular biology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Siokas, Vasileios</au><au>Aloizou, Athina-Maria</au><au>Liampas, Ioannis</au><au>Tsouris, Zisis</au><au>Mentis, Alexios-Fotios A.</au><au>Nasios, Grigorios</au><au>Papadimitriou, Dimitra</au><au>Bogdanos, Dimitrios P.</au><au>Hadjigeorgiou, Georgios M.</au><au>Dardiotis, Efthimios</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lack of association between TREM2 rs75932628 variant and amyotrophic lateral sclerosis</atitle><jtitle>Molecular biology reports</jtitle><stitle>Mol Biol Rep</stitle><addtitle>Mol Biol Rep</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>48</volume><issue>3</issue><spage>2601</spage><epage>2610</epage><pages>2601-2610</pages><issn>0301-4851</issn><eissn>1573-4978</eissn><abstract>Amyotrophic lateral sclerosis (ALS) is a multifactorial neurodegenerative disease. Inflammatory processes are among the mechanisms that are implicated in ALS pathogenesis. The TREM2 rs75932628 T variant may influence the regulatory effect of TREM2 on inflammation. Studies regarding the role of the rs75932628 variant in ALS have yielded inconsistent results, so far. To assess the role of TREM2 rs75932628 on ALS risk. We genotyped 155 patients with sporadic ALS and 155 healthy controls for TREM2 rs75932628. We also merged and meta-analyzed our data with data from previous studies (with a total of 7524 ALS cases and 14,675 controls), regarding TREM2 rs75932628 and ALS. No ALS or healthy subjects carried the TREM2 rs75932628-T variant. Results from meta-analyses (overall approach and sensitivity analyses) yielded no significant results for possible connection between TREM2 rs75932628-T variant and ALS. Based on our results, TREM2 rs75932628 does not seem to play a determining role to the pathophysiology of ALS.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>33826063</pmid><doi>10.1007/s11033-021-06312-1</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-2957-641X</orcidid></addata></record> |
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| subjects | Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - genetics Animal Anatomy Animal Biochemistry Biomedical and Life Sciences Cohort Studies Female Genetic Association Studies Genetic Predisposition to Disease Histology Humans Life Sciences Male Membrane Glycoproteins - genetics Meta-Analysis as Topic Middle Aged Morphology Neurodegenerative diseases Original Article Pathogenesis Polymorphism, Single Nucleotide - genetics Publication Bias Receptors, Immunologic - genetics Sensitivity analysis |
| title | Lack of association between TREM2 rs75932628 variant and amyotrophic lateral sclerosis |
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