Abnormal early folliculogenesis due to impeded pyruvate metabolism in mouse oocytes

Fetal ovarian germ cells show characteristic energy metabolism status, such as enhanced mitochondrial metabolism as well as glycolysis, but their roles in early folliculogenesis are unclear. We show here that inhibition of pyruvate uptake to mitochondria by UK5099 in organ cultures of fetal mouse ov...

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Veröffentlicht in:	Biology of reproduction 2021-07, Vol.105 (1), p.64-75
Hauptverfasser:	Tanaka, Keiko, Hayashi, Yohei, Takehara, Asuka, Ito-Matsuoka, Yumi, Tachibana, Masahito, Yaegashi, Nobuo, Matsui, Yasuhisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylates - pharmacology Animals Biological Transport Bone Morphogenetic Protein 15 - genetics Bone Morphogenetic Protein 15 - metabolism Cell culture Citric Acid Cycle Energy metabolism Ethylenediaminetetraacetic acid Female Fetuses Folliculogenesis GDF9 Gene Expression Regulation Germ cells Glycolysis Growth Differentiation Factor 9 - genetics Growth Differentiation Factor 9 - metabolism Ketoglutaric acid Meiosis Metabolism Metabolites Mice Mitochondria Mitochondria - metabolism MPC oocyte Oocytes Oocytes - drug effects Oocytes - metabolism Ovarian Follicle - growth & development Ovaries OXPHOS Physiological aspects pyruvate metabolism Pyruvic acid Pyruvic Acid - metabolism RESEARCH ARTICLE Transforming growth factors Tricarboxylic acid cycle UK5099
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