Hematopoietic stem progenitor cells lacking HLA differ from those lacking GPI-anchored proteins in the hierarchical stage and sensitivity to immune attack in patients with acquired aplastic anemia

To characterize glycosylphosphatidylinositol-anchored protein-deficient (GPI[−]) and HLA-class I allele-lacking (HLA[−]) hematopoietic stem progenitor cells (HSPCs) in acquired aplastic anemia (AA), we studied the peripheral blood (PB) of 56 AA patients in remission who possessed both ( n = 13, Gro...

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Veröffentlicht in:	Leukemia 2021-11, Vol.35 (11), p.3257-3267
Hauptverfasser:	Yoroidaka, Takeshi, Hosokawa, Kohei, Imi, Tatsuya, Mizumaki, Hiroki, Katagiri, Takamasa, Ishiyama, Ken, Yamazaki, Hirohito, Azuma, Fumihiro, Nanya, Yasuhito, Ogawa, Seishi, Nakao, Shinji
Format:	Artikel
Sprache:	eng
Schlagworte:	13/31 38/23 631/532/1542 692/699/1541/13 82/1 Adult Aged Aged, 80 and over Anemia Anemia, Aplastic - drug therapy Anemia, Aplastic - immunology Anemia, Aplastic - metabolism Anemia, Aplastic - pathology Aplastic anemia Cancer Research Cells (biology) Clone cells Critical Care Medicine Cyclosporine - pharmacology Cyclosporins Development and progression Female Follow-Up Studies Genetic aspects Glycosylphosphatidylinositol GPI-Linked Proteins - metabolism Granulocytes Granulocytes - drug effects Granulocytes - immunology Granulocytes - metabolism Granulocytes - pathology Health aspects Hematology Hematopoietic stem cells Hematopoietic Stem Cells - drug effects Hematopoietic Stem Cells - immunology Hematopoietic Stem Cells - metabolism Hematopoietic Stem Cells - pathology Histocompatibility antigen HLA Histocompatibility antigens HLA Antigens - metabolism HLA histocompatibility antigens Humans Immune response Immunosuppressive Agents - pharmacology Intensive Internal Medicine Leukocytes (granulocytic) Longitudinal studies Male Medicine Medicine & Public Health Middle Aged Oncology Peripheral blood Platelets Progenitor cells Proteins Remission Retrospective Studies Sensitivity Young Adult
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