The therapeutic potential of Nrf2 inducers in chronic pain: Evidence from preclinical studies

Chronic pain remains an enormous health problem affecting approximatively 30% of the world's population. Opioids as the first line analgesics often leads to undesirable side effects when used long term. Therefore, novel therapeutic targets are urgently needed to the development of more efficaci...

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Veröffentlicht in:	Pharmacology & therapeutics (Oxford) 2021-09, Vol.225, p.107846-107846, Article 107846
Hauptverfasser:	Zhou, Ya-Qun, Mei, Wei, Tian, Xue-Bi, Tian, Yu-Ke, Liu, Dai-Qiang, Ye, Da-Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics - pharmacology Animals Chronic pain Chronic Pain - drug therapy HO-1 Mice Mitochondrial function NF-E2-Related Factor 2 - pharmacology Nrf2 Oxidative stress Reactive Oxygen Species
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