Cell-specific epigenetic drivers of pathogenesis in rheumatoid arthritis

Rheumatoid arthritis is a complex, inflammatory autoimmune disease, which is characterized by pain, swelling and joint damage driven by the altered behavior of a number of different cell types such as synovial fibroblasts macrophages and lymphocytes. The mechanism underlying pathogenesis is unclear...

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Veröffentlicht in:	Epigenomics 2021-04, Vol.13 (7), p.549-560
Hauptverfasser:	Nair, Nisha, Barton, Anne, Wilson, Anthony G
Format:	Artikel
Sprache:	eng
Schlagworte:	Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - pathology bromodomain proteins DNA methylation Epigenesis, Genetic Fibroblasts - metabolism histone acetylation histone methylation histone modifications Humans rheumatoid arthritis Synovial Membrane - metabolism
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