Cell-specific epigenetic drivers of pathogenesis in rheumatoid arthritis
Rheumatoid arthritis is a complex, inflammatory autoimmune disease, which is characterized by pain, swelling and joint damage driven by the altered behavior of a number of different cell types such as synovial fibroblasts macrophages and lymphocytes. The mechanism underlying pathogenesis is unclear...
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| Veröffentlicht in: | Epigenomics 2021-04, Vol.13 (7), p.549-560 |
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| creator | Nair, Nisha Barton, Anne Wilson, Anthony G |
| description | Rheumatoid arthritis is a complex, inflammatory autoimmune disease, which is characterized by pain, swelling and joint damage driven by the altered behavior of a number of different cell types such as synovial fibroblasts macrophages and lymphocytes. The mechanism underlying pathogenesis is unclear but increasing evidence points to altered epigenetic regulation within these cell types which promotes the activated destructive behavior that underlies disease pathogenesis. This review summarizes the key epigenetic modifications in the most important cells types in rheumatoid arthritis, which are associated with disease activity. We also discuss emerging avenues of research focusing on readers of epigenetic markers which may serve to be potential therapeutic targets. |
| doi_str_mv | 10.2217/epi-2020-0380 |
| format | Article |
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The mechanism underlying pathogenesis is unclear but increasing evidence points to altered epigenetic regulation within these cell types which promotes the activated destructive behavior that underlies disease pathogenesis. This review summarizes the key epigenetic modifications in the most important cells types in rheumatoid arthritis, which are associated with disease activity. 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| fulltext | fulltext |
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| ispartof | Epigenomics, 2021-04, Vol.13 (7), p.549-560 |
| issn | 1750-1911 1750-192X |
| language | eng |
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| source | MEDLINE; PubMed Central |
| subjects | Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - pathology bromodomain proteins DNA methylation Epigenesis, Genetic Fibroblasts - metabolism histone acetylation histone methylation histone modifications Humans rheumatoid arthritis Synovial Membrane - metabolism |
| title | Cell-specific epigenetic drivers of pathogenesis in rheumatoid arthritis |
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