A three-dimensional virtual mouse generates synthetic training data for behavioral analysis
We developed a three-dimensional (3D) synthetic animated mouse based on computed tomography scans that is actuated using animation and semirandom, joint-constrained movements to generate synthetic behavioral data with ground-truth label locations. Image-domain translation produced realistic syntheti...
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| Veröffentlicht in: | Nature methods 2021-04, Vol.18 (4), p.378-381 |
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| container_title | Nature methods |
| container_volume | 18 |
| creator | Bolaños, Luis A. Xiao, Dongsheng Ford, Nancy L. LeDue, Jeff M. Gupta, Pankaj K. Doebeli, Carlos Hu, Hao Rhodin, Helge Murphy, Timothy H. |
| description | We developed a three-dimensional (3D) synthetic animated mouse based on computed tomography scans that is actuated using animation and semirandom, joint-constrained movements to generate synthetic behavioral data with ground-truth label locations. Image-domain translation produced realistic synthetic videos used to train two-dimensional (2D) and 3D pose estimation models with accuracy similar to typical manual training datasets. The outputs from the 3D model-based pose estimation yielded better definition of behavioral clusters than 2D videos and may facilitate automated ethological classification.
Bolaños et al. present a realistic three-dimensional virtual mouse model that can be animated and that facilitates the training of pose estimation algorithms. |
| doi_str_mv | 10.1038/s41592-021-01103-9 |
| format | Article |
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Bolaños et al. present a realistic three-dimensional virtual mouse model that can be animated and that facilitates the training of pose estimation algorithms.</description><subject>631/114/1564</subject><subject>631/1647/2198</subject><subject>631/1647/334/1874/345</subject><subject>631/1647/794</subject><subject>631/378/2632</subject><subject>Algorithms</subject><subject>Animal models</subject><subject>Animal models in research</subject><subject>Animals</subject><subject>Animation</subject><subject>Behavior</subject><subject>Behavior, Animal</subject><subject>Behavioral assessment</subject><subject>Bioinformatics</subject><subject>Biological Microscopy</subject><subject>Biological Techniques</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical Engineering/Biotechnology</subject><subject>Brief Communication</subject><subject>Cameras</subject><subject>Computed tomography</subject><subject>Computer simulation</subject><subject>CT 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Image-domain translation produced realistic synthetic videos used to train two-dimensional (2D) and 3D pose estimation models with accuracy similar to typical manual training datasets. The outputs from the 3D model-based pose estimation yielded better definition of behavioral clusters than 2D videos and may facilitate automated ethological classification.
Bolaños et al. present a realistic three-dimensional virtual mouse model that can be animated and that facilitates the training of pose estimation algorithms.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>33820989</pmid><doi>10.1038/s41592-021-01103-9</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0001-6814-2812</orcidid><orcidid>https://orcid.org/0000-0002-0093-4490</orcidid><orcidid>https://orcid.org/0000-0002-1669-0021</orcidid><orcidid>https://orcid.org/0000-0003-2692-0801</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 631/114/1564 631/1647/2198 631/1647/334/1874/345 631/1647/794 631/378/2632 Algorithms Animal models Animal models in research Animals Animation Behavior Behavior, Animal Behavioral assessment Bioinformatics Biological Microscopy Biological Techniques Biomedical and Life Sciences Biomedical Engineering/Biotechnology Brief Communication Cameras Computed tomography Computer simulation CT imaging Female Imaging, Three-Dimensional - methods Life Sciences Lighting Machine Learning Mechanical properties Methods Mice Mice, Inbred C57BL Model accuracy Mouse devices Noise Proteomics Reinforcement learning (Machine learning) Skin Technology application Three dimensional models Training Two dimensional models Video Virtual reality |
| title | A three-dimensional virtual mouse generates synthetic training data for behavioral analysis |
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