Facile fabrication of phospholipid-functionalized nanofiber-based barriers with enhanced anti-adhesion efficiency

[Display omitted] •Phospholipid functionalized nanofiber was readily fabricated via electrospinning.•The optimized NFMs possessed favorable morphology and excellent hydrophilicity.•Phospholipid NFMs showed superior inhibition of fibroblasts and anti-inflammation.•Phospholipid nanofiber-based barrier...

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Veröffentlicht in:Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2021-07, Vol.203, p.111728-111728, Article 111728
Hauptverfasser: Mao, Ying, Guidoin, Robert, Brochu, Gaëtan, Li, Yan, Zhang, Ze, Wang, Fujun, Wang, Lu
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container_title Colloids and surfaces, B, Biointerfaces
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creator Mao, Ying
Guidoin, Robert
Brochu, Gaëtan
Li, Yan
Zhang, Ze
Wang, Fujun
Wang, Lu
description [Display omitted] •Phospholipid functionalized nanofiber was readily fabricated via electrospinning.•The optimized NFMs possessed favorable morphology and excellent hydrophilicity.•Phospholipid NFMs showed superior inhibition of fibroblasts and anti-inflammation.•Phospholipid nanofiber-based barriers exhibited enhancing anti-adhesion efficacy. Electrospun nanofibrous membranes (NFMs) have attracted considerable attention as a potential physical barrier for reducing postoperative adhesion. However, no anti-adhesion barrier can completely prevent adhesion formation. In this study, phospholipid-functionalized NFMs were readily fabricated by one-step electrospinning to obtain nanofiber-based barriers with enhanced wettability and anti-adhesion efficiency. The optimized phospholipid NFMs were shown to have a fiber diameter of 831 nm ± 135 nm that is drastically decreasing, high porosity of 87.6 % ± 1.1 %, and superior hydrophilicity. Moreover, the phospholipid NFMs with excellent cytocompatibility exhibited fibroblasts being significantly reduced (≈ 51 %) after incubation of 3 days compared to that of the NFMs (≈ 96 %), confirming long-lasting anti-adhesion capability against fibroblasts. Meanwhile, less cell adhesion and proliferation of Raw 264.7 macrophages on NFM-10Lec indicated its superior anti-inflammatory effects. Thus, the facile phospholipid-functionalized nanofibers provided a promising strategy for anti-adhesion applications.
doi_str_mv 10.1016/j.colsurfb.2021.111728
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Electrospun nanofibrous membranes (NFMs) have attracted considerable attention as a potential physical barrier for reducing postoperative adhesion. However, no anti-adhesion barrier can completely prevent adhesion formation. In this study, phospholipid-functionalized NFMs were readily fabricated by one-step electrospinning to obtain nanofiber-based barriers with enhanced wettability and anti-adhesion efficiency. The optimized phospholipid NFMs were shown to have a fiber diameter of 831 nm ± 135 nm that is drastically decreasing, high porosity of 87.6 % ± 1.1 %, and superior hydrophilicity. Moreover, the phospholipid NFMs with excellent cytocompatibility exhibited fibroblasts being significantly reduced (≈ 51 %) after incubation of 3 days compared to that of the NFMs (≈ 96 %), confirming long-lasting anti-adhesion capability against fibroblasts. Meanwhile, less cell adhesion and proliferation of Raw 264.7 macrophages on NFM-10Lec indicated its superior anti-inflammatory effects. 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Electrospun nanofibrous membranes (NFMs) have attracted considerable attention as a potential physical barrier for reducing postoperative adhesion. However, no anti-adhesion barrier can completely prevent adhesion formation. In this study, phospholipid-functionalized NFMs were readily fabricated by one-step electrospinning to obtain nanofiber-based barriers with enhanced wettability and anti-adhesion efficiency. The optimized phospholipid NFMs were shown to have a fiber diameter of 831 nm ± 135 nm that is drastically decreasing, high porosity of 87.6 % ± 1.1 %, and superior hydrophilicity. Moreover, the phospholipid NFMs with excellent cytocompatibility exhibited fibroblasts being significantly reduced (≈ 51 %) after incubation of 3 days compared to that of the NFMs (≈ 96 %), confirming long-lasting anti-adhesion capability against fibroblasts. Meanwhile, less cell adhesion and proliferation of Raw 264.7 macrophages on NFM-10Lec indicated its superior anti-inflammatory effects. 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subjects Anti-adhesion
Anti-inflammation
Fibroblast
Nanofiber-based barrier
Phospholipid
title Facile fabrication of phospholipid-functionalized nanofiber-based barriers with enhanced anti-adhesion efficiency
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