Structural insights into preinitiation complex assembly on core promoters

Transcription factor IID (TFIID) recognizes core promoters and supports preinitiation complex (PIC) assembly for RNA polymerase II (Pol II)-mediated eukaryotic transcription. We determined the structures of human TFIID-based PIC in three stepwise assembly states and revealed two-track PIC assembly:...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2021-04, Vol.372 (6541)
Hauptverfasser:	Chen, Xizi, Qi, Yilun, Wu, Zihan, Wang, Xinxin, Li, Jiabei, Zhao, Dan, Hou, Haifeng, Li, Yan, Yu, Zishuo, Liu, Weida, Wang, Mo, Ren, Yulei, Li, Ze, Yang, Huirong, Xu, Yanhui
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Regulatory Proteins - genetics Assembling Assembly Bends Coding Convergence Corticotropin-Releasing Hormone - genetics Cryoelectron Microscopy Cyclin-dependent kinase 7 Cyclin-dependent kinases Cyclin-Dependent Kinases - chemistry Deposition DNA-directed RNA polymerase Domains Epigenetics Genes HEK293 Cells Humans Kinases Multiprotein Complexes - chemistry Phosphorylation Promoter Regions, Genetic Promoters Protein Binding Protein Domains Proteins Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins c-mdm2 - genetics Regulators Ribonucleic acid RNA RNA polymerase RNA polymerase II RNA Polymerase II - chemistry Swine Tata box TFIID protein Transcription Factor TFIID - chemistry Transcription factors Transcription initiation factor TFIIA Transcription initiation factor TFIIB Transcription Initiation, Genetic Urocortins - genetics Visualization
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