Glycolipid-Containing Nanoparticle Vaccine Engages Invariant NKT Cells to Enhance Humoral Protection against Systemic Bacterial Infection but Abrogates T-Independent Vaccine Responses

CD4 T cells enable the critical B cell humoral immune protection afforded by most effective vaccines. We and others have recently identified an alternative source of help for B cells in mice, invariant NK T (iNKT) cells. iNKT cells are innate glycolipid-specific T cells restricted to the nonpolymorp...

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Veröffentlicht in:	The Journal of immunology (1950) 2021-04, Vol.206 (8), p.1806-1816
Hauptverfasser:	Shute, Travis, Amiel, Eyal, Alam, Noran, Yates, Jennifer L, Mohrs, Katya, Dudley, Elizabeth, Salas, Briana, Mesa, Chloe, Serrata, Adriana, Angel, Daniel, Vincent, Brandy K, Weyers, Amanda, Lanthier, Paula A, Vomhof-Dekrey, Emilie, Fromme, Rachel, Laughlin, Mitchell, Durham, Olivia, Miao, Jianjun, Shipp, Devon, Linhardt, Robert J, Nash, Kelly, Leadbetter, Elizabeth A
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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