A prospective randomized tandem gastroscopy pilot study of linked color imaging versus white light imaging for detection of upper gastrointestinal lesions
Background and Aim Gastrointestinal (GI) lesions may have subtle morphological changes. Linked color imaging (LCI) combines narrow‐band wavelength light and white light imaging (WLI) in appropriate balance to enhance lesion detection. We compared the detection rates of upper GI lesions using LCI and...
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| Veröffentlicht in: | Journal of gastroenterology and hepatology 2021-09, Vol.36 (9), p.2562-2567 |
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| creator | Wu, Clement Chun Ho Namasivayam, Vikneswaran Li, James Weiquan Khor, Chris JL Fock, Kwong Ming Law, Ngai Moh Wang, Lai Mun Ang, Tiing Leong |
| description | Background and Aim
Gastrointestinal (GI) lesions may have subtle morphological changes. Linked color imaging (LCI) combines narrow‐band wavelength light and white light imaging (WLI) in appropriate balance to enhance lesion detection. We compared the detection rates of upper GI lesions using LCI and WLI.
Method
Patients were randomized in a 1:1 ratio to receive tandem gastroscopy with WLI inspection followed by LCI, or vice versa. Endoscopic examination was performed using the EG‐L590ZW gastroscope and the LASEREO endoscope system (Fujifilm Co., Tokyo, Japan). Histology was reported by a specialist GI pathologist blinded to the technique of lesion detection and was used as the gold standard for diagnosis.
Results
Ninety patients (mean age 66.8 years, 51.5% male patients) were randomized to either LCI examination first followed by WLI (LCI‐WLI), or vice versa (WLI‐LCI). An 18.9% of gastroscopies in the study were for surveillance of previously known gastric cancer precursors. Ten patients (11.1%) had a history of Helicobacter pylori infection. There was no significant difference in the time taken for examination under LCI (311 ± 96 s) and WLI (342 ± 86 s) (P = 0.700). LCI detection rates were higher than WLI detection rates for gastric cancer precursors such as atrophic gastritis (2.19% vs 0.55%) (P |
| doi_str_mv | 10.1111/jgh.15515 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2508577405</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2508577405</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3535-cc7f8bb27a07a4f954e6d7c116cecd736ae255a28699af02b35f77747d3851263</originalsourceid><addsrcrecordid>eNp10cFu1DAQBmALgehSOPACyBIXOKS1YztOjlUFLahSL-UceZ1J1osTB9tptX2UPi2z7NIDEr7Ykj__Y80Q8p6zM47rfDtszrhSXL0gKy4lK7iW1UuyYjVXRSN4c0LepLRljEmm1WtyIkTNuajVijxd0DmGNIPN7h5oNFMXRvcIHc14hJEOJmUENsw7OjsfMk156XY09NS76SdCG3yI1I1mcNNA7yGmJdGHjcuAYtjk56seWQd5XypM-4BlniEeK7gpQ8puMp56SAjSW_KqNz7Bu-N-Sn58_XJ3eV3c3F59u7y4KaxQQhXW6r5er0ttmDayb5SEqtOW88qC7bSoDJRKmbKumsb0rFwL1Wutpe6wAbysxCn5dMjFRvxa8BPt6JIF780EYUltqVit8AFTSD_-Q7dhifjnvdKcSS4rierzQVlsXIrQt3PEHsRdy1m7H1iLA2v_DAzth2Pish6he5Z_J4Tg_AAenIfd_5Pa71fXh8jfAcWioQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2571041464</pqid></control><display><type>article</type><title>A prospective randomized tandem gastroscopy pilot study of linked color imaging versus white light imaging for detection of upper gastrointestinal lesions</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Wu, Clement Chun Ho ; Namasivayam, Vikneswaran ; Li, James Weiquan ; Khor, Chris JL ; Fock, Kwong Ming ; Law, Ngai Moh ; Wang, Lai Mun ; Ang, Tiing Leong</creator><creatorcontrib>Wu, Clement Chun Ho ; Namasivayam, Vikneswaran ; Li, James Weiquan ; Khor, Chris JL ; Fock, Kwong Ming ; Law, Ngai Moh ; Wang, Lai Mun ; Ang, Tiing Leong</creatorcontrib><description>Background and Aim
Gastrointestinal (GI) lesions may have subtle morphological changes. Linked color imaging (LCI) combines narrow‐band wavelength light and white light imaging (WLI) in appropriate balance to enhance lesion detection. We compared the detection rates of upper GI lesions using LCI and WLI.
Method
Patients were randomized in a 1:1 ratio to receive tandem gastroscopy with WLI inspection followed by LCI, or vice versa. Endoscopic examination was performed using the EG‐L590ZW gastroscope and the LASEREO endoscope system (Fujifilm Co., Tokyo, Japan). Histology was reported by a specialist GI pathologist blinded to the technique of lesion detection and was used as the gold standard for diagnosis.
Results
Ninety patients (mean age 66.8 years, 51.5% male patients) were randomized to either LCI examination first followed by WLI (LCI‐WLI), or vice versa (WLI‐LCI). An 18.9% of gastroscopies in the study were for surveillance of previously known gastric cancer precursors. Ten patients (11.1%) had a history of Helicobacter pylori infection. There was no significant difference in the time taken for examination under LCI (311 ± 96 s) and WLI (342 ± 86 s) (P = 0.700). LCI detection rates were higher than WLI detection rates for gastric cancer precursors such as atrophic gastritis (2.19% vs 0.55%) (P < 0.01) and intestinal metaplasia (19.73% vs 7.67%) (P < 0.01). Both sensitivity (82.74% vs 50.96%) and specificity (98.71% vs 96.10%) of LCI were higher than WLI for detection of upper GI lesions.
Conclusions
Linked color imaging had better detection rates, sensitivity, and specificity for detection of upper GI lesions compared with WLI.</description><identifier>ISSN: 0815-9319</identifier><identifier>EISSN: 1440-1746</identifier><identifier>DOI: 10.1111/jgh.15515</identifier><identifier>PMID: 33811385</identifier><language>eng</language><publisher>Australia: Wiley Subscription Services, Inc</publisher><subject>Aged ; Color ; Endoscopes ; Female ; Gastric cancer ; gastric cancer precursors ; Gastritis ; Gastroscopy ; Gastroscopy - methods ; Helicobacter Infections - complications ; Helicobacter pylori ; Histology ; Humans ; image enhanced endoscopy ; Image Enhancement ; Lesions ; linked color imaging ; Male ; Metaplasia ; Middle Aged ; Optical Imaging - methods ; Pilot Projects ; Prospective Studies ; Sensitivity and Specificity ; Stomach - diagnostic imaging ; Stomach - pathology ; Stomach Neoplasms - diagnostic imaging ; Stomach Neoplasms - etiology ; Stomach Neoplasms - pathology ; tandem gastroscopy</subject><ispartof>Journal of gastroenterology and hepatology, 2021-09, Vol.36 (9), p.2562-2567</ispartof><rights>2021 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd</rights><rights>2021 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3535-cc7f8bb27a07a4f954e6d7c116cecd736ae255a28699af02b35f77747d3851263</citedby><cites>FETCH-LOGICAL-c3535-cc7f8bb27a07a4f954e6d7c116cecd736ae255a28699af02b35f77747d3851263</cites><orcidid>0000-0002-5241-4278 ; 0000-0001-9993-8549</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjgh.15515$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjgh.15515$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33811385$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Clement Chun Ho</creatorcontrib><creatorcontrib>Namasivayam, Vikneswaran</creatorcontrib><creatorcontrib>Li, James Weiquan</creatorcontrib><creatorcontrib>Khor, Chris JL</creatorcontrib><creatorcontrib>Fock, Kwong Ming</creatorcontrib><creatorcontrib>Law, Ngai Moh</creatorcontrib><creatorcontrib>Wang, Lai Mun</creatorcontrib><creatorcontrib>Ang, Tiing Leong</creatorcontrib><title>A prospective randomized tandem gastroscopy pilot study of linked color imaging versus white light imaging for detection of upper gastrointestinal lesions</title><title>Journal of gastroenterology and hepatology</title><addtitle>J Gastroenterol Hepatol</addtitle><description>Background and Aim
Gastrointestinal (GI) lesions may have subtle morphological changes. Linked color imaging (LCI) combines narrow‐band wavelength light and white light imaging (WLI) in appropriate balance to enhance lesion detection. We compared the detection rates of upper GI lesions using LCI and WLI.
Method
Patients were randomized in a 1:1 ratio to receive tandem gastroscopy with WLI inspection followed by LCI, or vice versa. Endoscopic examination was performed using the EG‐L590ZW gastroscope and the LASEREO endoscope system (Fujifilm Co., Tokyo, Japan). Histology was reported by a specialist GI pathologist blinded to the technique of lesion detection and was used as the gold standard for diagnosis.
Results
Ninety patients (mean age 66.8 years, 51.5% male patients) were randomized to either LCI examination first followed by WLI (LCI‐WLI), or vice versa (WLI‐LCI). An 18.9% of gastroscopies in the study were for surveillance of previously known gastric cancer precursors. Ten patients (11.1%) had a history of Helicobacter pylori infection. There was no significant difference in the time taken for examination under LCI (311 ± 96 s) and WLI (342 ± 86 s) (P = 0.700). LCI detection rates were higher than WLI detection rates for gastric cancer precursors such as atrophic gastritis (2.19% vs 0.55%) (P < 0.01) and intestinal metaplasia (19.73% vs 7.67%) (P < 0.01). Both sensitivity (82.74% vs 50.96%) and specificity (98.71% vs 96.10%) of LCI were higher than WLI for detection of upper GI lesions.
Conclusions
Linked color imaging had better detection rates, sensitivity, and specificity for detection of upper GI lesions compared with WLI.</description><subject>Aged</subject><subject>Color</subject><subject>Endoscopes</subject><subject>Female</subject><subject>Gastric cancer</subject><subject>gastric cancer precursors</subject><subject>Gastritis</subject><subject>Gastroscopy</subject><subject>Gastroscopy - methods</subject><subject>Helicobacter Infections - complications</subject><subject>Helicobacter pylori</subject><subject>Histology</subject><subject>Humans</subject><subject>image enhanced endoscopy</subject><subject>Image Enhancement</subject><subject>Lesions</subject><subject>linked color imaging</subject><subject>Male</subject><subject>Metaplasia</subject><subject>Middle Aged</subject><subject>Optical Imaging - methods</subject><subject>Pilot Projects</subject><subject>Prospective Studies</subject><subject>Sensitivity and Specificity</subject><subject>Stomach - diagnostic imaging</subject><subject>Stomach - pathology</subject><subject>Stomach Neoplasms - diagnostic imaging</subject><subject>Stomach Neoplasms - etiology</subject><subject>Stomach Neoplasms - pathology</subject><subject>tandem gastroscopy</subject><issn>0815-9319</issn><issn>1440-1746</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10cFu1DAQBmALgehSOPACyBIXOKS1YztOjlUFLahSL-UceZ1J1osTB9tptX2UPi2z7NIDEr7Ykj__Y80Q8p6zM47rfDtszrhSXL0gKy4lK7iW1UuyYjVXRSN4c0LepLRljEmm1WtyIkTNuajVijxd0DmGNIPN7h5oNFMXRvcIHc14hJEOJmUENsw7OjsfMk156XY09NS76SdCG3yI1I1mcNNA7yGmJdGHjcuAYtjk56seWQd5XypM-4BlniEeK7gpQ8puMp56SAjSW_KqNz7Bu-N-Sn58_XJ3eV3c3F59u7y4KaxQQhXW6r5er0ttmDayb5SEqtOW88qC7bSoDJRKmbKumsb0rFwL1Wutpe6wAbysxCn5dMjFRvxa8BPt6JIF780EYUltqVit8AFTSD_-Q7dhifjnvdKcSS4rierzQVlsXIrQt3PEHsRdy1m7H1iLA2v_DAzth2Pish6he5Z_J4Tg_AAenIfd_5Pa71fXh8jfAcWioQ</recordid><startdate>202109</startdate><enddate>202109</enddate><creator>Wu, Clement Chun Ho</creator><creator>Namasivayam, Vikneswaran</creator><creator>Li, James Weiquan</creator><creator>Khor, Chris JL</creator><creator>Fock, Kwong Ming</creator><creator>Law, Ngai Moh</creator><creator>Wang, Lai Mun</creator><creator>Ang, Tiing Leong</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5241-4278</orcidid><orcidid>https://orcid.org/0000-0001-9993-8549</orcidid></search><sort><creationdate>202109</creationdate><title>A prospective randomized tandem gastroscopy pilot study of linked color imaging versus white light imaging for detection of upper gastrointestinal lesions</title><author>Wu, Clement Chun Ho ; Namasivayam, Vikneswaran ; Li, James Weiquan ; Khor, Chris JL ; Fock, Kwong Ming ; Law, Ngai Moh ; Wang, Lai Mun ; Ang, Tiing Leong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3535-cc7f8bb27a07a4f954e6d7c116cecd736ae255a28699af02b35f77747d3851263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aged</topic><topic>Color</topic><topic>Endoscopes</topic><topic>Female</topic><topic>Gastric cancer</topic><topic>gastric cancer precursors</topic><topic>Gastritis</topic><topic>Gastroscopy</topic><topic>Gastroscopy - methods</topic><topic>Helicobacter Infections - complications</topic><topic>Helicobacter pylori</topic><topic>Histology</topic><topic>Humans</topic><topic>image enhanced endoscopy</topic><topic>Image Enhancement</topic><topic>Lesions</topic><topic>linked color imaging</topic><topic>Male</topic><topic>Metaplasia</topic><topic>Middle Aged</topic><topic>Optical Imaging - methods</topic><topic>Pilot Projects</topic><topic>Prospective Studies</topic><topic>Sensitivity and Specificity</topic><topic>Stomach - diagnostic imaging</topic><topic>Stomach - pathology</topic><topic>Stomach Neoplasms - diagnostic imaging</topic><topic>Stomach Neoplasms - etiology</topic><topic>Stomach Neoplasms - pathology</topic><topic>tandem gastroscopy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Clement Chun Ho</creatorcontrib><creatorcontrib>Namasivayam, Vikneswaran</creatorcontrib><creatorcontrib>Li, James Weiquan</creatorcontrib><creatorcontrib>Khor, Chris JL</creatorcontrib><creatorcontrib>Fock, Kwong Ming</creatorcontrib><creatorcontrib>Law, Ngai Moh</creatorcontrib><creatorcontrib>Wang, Lai Mun</creatorcontrib><creatorcontrib>Ang, Tiing Leong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastroenterology and hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Clement Chun Ho</au><au>Namasivayam, Vikneswaran</au><au>Li, James Weiquan</au><au>Khor, Chris JL</au><au>Fock, Kwong Ming</au><au>Law, Ngai Moh</au><au>Wang, Lai Mun</au><au>Ang, Tiing Leong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A prospective randomized tandem gastroscopy pilot study of linked color imaging versus white light imaging for detection of upper gastrointestinal lesions</atitle><jtitle>Journal of gastroenterology and hepatology</jtitle><addtitle>J Gastroenterol Hepatol</addtitle><date>2021-09</date><risdate>2021</risdate><volume>36</volume><issue>9</issue><spage>2562</spage><epage>2567</epage><pages>2562-2567</pages><issn>0815-9319</issn><eissn>1440-1746</eissn><abstract>Background and Aim
Gastrointestinal (GI) lesions may have subtle morphological changes. Linked color imaging (LCI) combines narrow‐band wavelength light and white light imaging (WLI) in appropriate balance to enhance lesion detection. We compared the detection rates of upper GI lesions using LCI and WLI.
Method
Patients were randomized in a 1:1 ratio to receive tandem gastroscopy with WLI inspection followed by LCI, or vice versa. Endoscopic examination was performed using the EG‐L590ZW gastroscope and the LASEREO endoscope system (Fujifilm Co., Tokyo, Japan). Histology was reported by a specialist GI pathologist blinded to the technique of lesion detection and was used as the gold standard for diagnosis.
Results
Ninety patients (mean age 66.8 years, 51.5% male patients) were randomized to either LCI examination first followed by WLI (LCI‐WLI), or vice versa (WLI‐LCI). An 18.9% of gastroscopies in the study were for surveillance of previously known gastric cancer precursors. Ten patients (11.1%) had a history of Helicobacter pylori infection. There was no significant difference in the time taken for examination under LCI (311 ± 96 s) and WLI (342 ± 86 s) (P = 0.700). LCI detection rates were higher than WLI detection rates for gastric cancer precursors such as atrophic gastritis (2.19% vs 0.55%) (P < 0.01) and intestinal metaplasia (19.73% vs 7.67%) (P < 0.01). Both sensitivity (82.74% vs 50.96%) and specificity (98.71% vs 96.10%) of LCI were higher than WLI for detection of upper GI lesions.
Conclusions
Linked color imaging had better detection rates, sensitivity, and specificity for detection of upper GI lesions compared with WLI.</abstract><cop>Australia</cop><pub>Wiley Subscription Services, Inc</pub><pmid>33811385</pmid><doi>10.1111/jgh.15515</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-5241-4278</orcidid><orcidid>https://orcid.org/0000-0001-9993-8549</orcidid></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged Color Endoscopes Female Gastric cancer gastric cancer precursors Gastritis Gastroscopy Gastroscopy - methods Helicobacter Infections - complications Helicobacter pylori Histology Humans image enhanced endoscopy Image Enhancement Lesions linked color imaging Male Metaplasia Middle Aged Optical Imaging - methods Pilot Projects Prospective Studies Sensitivity and Specificity Stomach - diagnostic imaging Stomach - pathology Stomach Neoplasms - diagnostic imaging Stomach Neoplasms - etiology Stomach Neoplasms - pathology tandem gastroscopy |
| title | A prospective randomized tandem gastroscopy pilot study of linked color imaging versus white light imaging for detection of upper gastrointestinal lesions |
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