Are the oxidative stress levels in the tumor center and tumor boundary different from those in healthy tissue?
Purpose This study aimed to investigate the relationship between oxidative stress levels in the tumor center, tumor edge, and healthy tissue. Methods This study included a total of 53 patients with head and neck cancer. Samples of 5 × 5 × 5 mm were collected from the tumor center, tumor edge, and th...
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| Veröffentlicht in: | European archives of oto-rhino-laryngology 2021-12, Vol.278 (12), p.5013-5020 |
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| container_title | European archives of oto-rhino-laryngology |
| container_volume | 278 |
| creator | Dogan, Remzi Guler, Eray Metin Kocyigit, Abdurrahim Çelik, İsmail Senturk, Erol Yenigun, Alper Tugrul, Selahattin Ozturan, Orhan |
| description | Purpose
This study aimed to investigate the relationship between oxidative stress levels in the tumor center, tumor edge, and healthy tissue.
Methods
This study included a total of 53 patients with head and neck cancer. Samples of 5 × 5 × 5 mm were collected from the tumor center, tumor edge, and the healthy tissue. Total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) values were evaluated. (1) Oxidative stress values in the center and edge of all tumors and in healthy tissues were compared according to localization. (2) Tumors were divided into two groups as malignant (Group 1 [
n
= 28]: Laryngeal and tongue squamous cell cancers) and benign (Group 2 [
n
= 25]: Pleomorphic adenoma and Warthin tumors). The groups were compared according to the localization of the tissues.
Results
The TOS value in the tumor edge was significantly higher than those in the tumor center and the healthy tissue. The TAS value in tissue located in the tumor edge was significantly higher than in the healthy tissue. The OSI value in the tumor edge was significantly higher than those in the tumor center and the healthy tissue.
In all three localizations (tumor center, tumor edge, and healthy tissue), TOS and OSI values in Group 1 were significantly higher than Group 2.
Conclusion
Oxidative stress values in the tumor edge are significantly higher than the center of the tumor and healthy tissue. In malignant tumors, oxidative stress values are significantly higher in all localizations compared to benign tumors. |
| doi_str_mv | 10.1007/s00405-021-06749-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2508576380</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2508576380</sourcerecordid><originalsourceid>FETCH-LOGICAL-c347t-aa5f69ea8089aac4f062ef357c008997ef351c32ecb7e03228c8f7b01d8febf63</originalsourceid><addsrcrecordid>eNp9kEtP3DAQx62qqCyPL9BD5WMvgXHsxMmpQogWJCQucLYcZ9zNKompx0HLt8f7aI89zWj-D2l-jH0VcCUA9DUBKKgKKEUBtVZtsf3EVkJJVShd1p_ZClqpC6W0PmVnRBsAqFQrv7BTKRsh8r5i801EntbIw3bobRrekFOKSMRHfMOR-DDv5bRMIXKHc8LI7dwfD11Y5t7Gd94P3mPMMvcxTDkSCHfZNdoxrd95GogW_HHBTrwdCS-P85y9_Lx7vr0vHp9-PdzePBZOKp0Kaytft2gbaFprnfJQl-hlpR3kS6t3u3CyRNdpBFmWjWu87kD0jcfO1_KcfT_0vsbwZ0FKZhrI4TjaGcNCpqygqXQtG8jW8mB1MRBF9OY1DlP-yQgwO87mwNlkzmbP2Wxz6Nuxf-km7P9F_oLNBnkwUJbm3xjNJixxzj__r_YDyqGLTQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2508576380</pqid></control><display><type>article</type><title>Are the oxidative stress levels in the tumor center and tumor boundary different from those in healthy tissue?</title><source>Springer Nature - Complete Springer Journals</source><creator>Dogan, Remzi ; Guler, Eray Metin ; Kocyigit, Abdurrahim ; Çelik, İsmail ; Senturk, Erol ; Yenigun, Alper ; Tugrul, Selahattin ; Ozturan, Orhan</creator><creatorcontrib>Dogan, Remzi ; Guler, Eray Metin ; Kocyigit, Abdurrahim ; Çelik, İsmail ; Senturk, Erol ; Yenigun, Alper ; Tugrul, Selahattin ; Ozturan, Orhan</creatorcontrib><description>Purpose
This study aimed to investigate the relationship between oxidative stress levels in the tumor center, tumor edge, and healthy tissue.
Methods
This study included a total of 53 patients with head and neck cancer. Samples of 5 × 5 × 5 mm were collected from the tumor center, tumor edge, and the healthy tissue. Total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) values were evaluated. (1) Oxidative stress values in the center and edge of all tumors and in healthy tissues were compared according to localization. (2) Tumors were divided into two groups as malignant (Group 1 [
n
= 28]: Laryngeal and tongue squamous cell cancers) and benign (Group 2 [
n
= 25]: Pleomorphic adenoma and Warthin tumors). The groups were compared according to the localization of the tissues.
Results
The TOS value in the tumor edge was significantly higher than those in the tumor center and the healthy tissue. The TAS value in tissue located in the tumor edge was significantly higher than in the healthy tissue. The OSI value in the tumor edge was significantly higher than those in the tumor center and the healthy tissue.
In all three localizations (tumor center, tumor edge, and healthy tissue), TOS and OSI values in Group 1 were significantly higher than Group 2.
Conclusion
Oxidative stress values in the tumor edge are significantly higher than the center of the tumor and healthy tissue. In malignant tumors, oxidative stress values are significantly higher in all localizations compared to benign tumors.</description><identifier>ISSN: 0937-4477</identifier><identifier>EISSN: 1434-4726</identifier><identifier>DOI: 10.1007/s00405-021-06749-x</identifier><identifier>PMID: 33811549</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Head and Neck ; Head and Neck Surgery ; Medicine ; Medicine & Public Health ; Neurosurgery ; Otorhinolaryngology</subject><ispartof>European archives of oto-rhino-laryngology, 2021-12, Vol.278 (12), p.5013-5020</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-aa5f69ea8089aac4f062ef357c008997ef351c32ecb7e03228c8f7b01d8febf63</citedby><cites>FETCH-LOGICAL-c347t-aa5f69ea8089aac4f062ef357c008997ef351c32ecb7e03228c8f7b01d8febf63</cites><orcidid>0000-0001-5627-1342</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00405-021-06749-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00405-021-06749-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33811549$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dogan, Remzi</creatorcontrib><creatorcontrib>Guler, Eray Metin</creatorcontrib><creatorcontrib>Kocyigit, Abdurrahim</creatorcontrib><creatorcontrib>Çelik, İsmail</creatorcontrib><creatorcontrib>Senturk, Erol</creatorcontrib><creatorcontrib>Yenigun, Alper</creatorcontrib><creatorcontrib>Tugrul, Selahattin</creatorcontrib><creatorcontrib>Ozturan, Orhan</creatorcontrib><title>Are the oxidative stress levels in the tumor center and tumor boundary different from those in healthy tissue?</title><title>European archives of oto-rhino-laryngology</title><addtitle>Eur Arch Otorhinolaryngol</addtitle><addtitle>Eur Arch Otorhinolaryngol</addtitle><description>Purpose
This study aimed to investigate the relationship between oxidative stress levels in the tumor center, tumor edge, and healthy tissue.
Methods
This study included a total of 53 patients with head and neck cancer. Samples of 5 × 5 × 5 mm were collected from the tumor center, tumor edge, and the healthy tissue. Total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) values were evaluated. (1) Oxidative stress values in the center and edge of all tumors and in healthy tissues were compared according to localization. (2) Tumors were divided into two groups as malignant (Group 1 [
n
= 28]: Laryngeal and tongue squamous cell cancers) and benign (Group 2 [
n
= 25]: Pleomorphic adenoma and Warthin tumors). The groups were compared according to the localization of the tissues.
Results
The TOS value in the tumor edge was significantly higher than those in the tumor center and the healthy tissue. The TAS value in tissue located in the tumor edge was significantly higher than in the healthy tissue. The OSI value in the tumor edge was significantly higher than those in the tumor center and the healthy tissue.
In all three localizations (tumor center, tumor edge, and healthy tissue), TOS and OSI values in Group 1 were significantly higher than Group 2.
Conclusion
Oxidative stress values in the tumor edge are significantly higher than the center of the tumor and healthy tissue. In malignant tumors, oxidative stress values are significantly higher in all localizations compared to benign tumors.</description><subject>Head and Neck</subject><subject>Head and Neck Surgery</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurosurgery</subject><subject>Otorhinolaryngology</subject><issn>0937-4477</issn><issn>1434-4726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kEtP3DAQx62qqCyPL9BD5WMvgXHsxMmpQogWJCQucLYcZ9zNKompx0HLt8f7aI89zWj-D2l-jH0VcCUA9DUBKKgKKEUBtVZtsf3EVkJJVShd1p_ZClqpC6W0PmVnRBsAqFQrv7BTKRsh8r5i801EntbIw3bobRrekFOKSMRHfMOR-DDv5bRMIXKHc8LI7dwfD11Y5t7Gd94P3mPMMvcxTDkSCHfZNdoxrd95GogW_HHBTrwdCS-P85y9_Lx7vr0vHp9-PdzePBZOKp0Kaytft2gbaFprnfJQl-hlpR3kS6t3u3CyRNdpBFmWjWu87kD0jcfO1_KcfT_0vsbwZ0FKZhrI4TjaGcNCpqygqXQtG8jW8mB1MRBF9OY1DlP-yQgwO87mwNlkzmbP2Wxz6Nuxf-km7P9F_oLNBnkwUJbm3xjNJixxzj__r_YDyqGLTQ</recordid><startdate>20211201</startdate><enddate>20211201</enddate><creator>Dogan, Remzi</creator><creator>Guler, Eray Metin</creator><creator>Kocyigit, Abdurrahim</creator><creator>Çelik, İsmail</creator><creator>Senturk, Erol</creator><creator>Yenigun, Alper</creator><creator>Tugrul, Selahattin</creator><creator>Ozturan, Orhan</creator><general>Springer Berlin Heidelberg</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5627-1342</orcidid></search><sort><creationdate>20211201</creationdate><title>Are the oxidative stress levels in the tumor center and tumor boundary different from those in healthy tissue?</title><author>Dogan, Remzi ; Guler, Eray Metin ; Kocyigit, Abdurrahim ; Çelik, İsmail ; Senturk, Erol ; Yenigun, Alper ; Tugrul, Selahattin ; Ozturan, Orhan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-aa5f69ea8089aac4f062ef357c008997ef351c32ecb7e03228c8f7b01d8febf63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Head and Neck</topic><topic>Head and Neck Surgery</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurosurgery</topic><topic>Otorhinolaryngology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dogan, Remzi</creatorcontrib><creatorcontrib>Guler, Eray Metin</creatorcontrib><creatorcontrib>Kocyigit, Abdurrahim</creatorcontrib><creatorcontrib>Çelik, İsmail</creatorcontrib><creatorcontrib>Senturk, Erol</creatorcontrib><creatorcontrib>Yenigun, Alper</creatorcontrib><creatorcontrib>Tugrul, Selahattin</creatorcontrib><creatorcontrib>Ozturan, Orhan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European archives of oto-rhino-laryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dogan, Remzi</au><au>Guler, Eray Metin</au><au>Kocyigit, Abdurrahim</au><au>Çelik, İsmail</au><au>Senturk, Erol</au><au>Yenigun, Alper</au><au>Tugrul, Selahattin</au><au>Ozturan, Orhan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Are the oxidative stress levels in the tumor center and tumor boundary different from those in healthy tissue?</atitle><jtitle>European archives of oto-rhino-laryngology</jtitle><stitle>Eur Arch Otorhinolaryngol</stitle><addtitle>Eur Arch Otorhinolaryngol</addtitle><date>2021-12-01</date><risdate>2021</risdate><volume>278</volume><issue>12</issue><spage>5013</spage><epage>5020</epage><pages>5013-5020</pages><issn>0937-4477</issn><eissn>1434-4726</eissn><abstract>Purpose
This study aimed to investigate the relationship between oxidative stress levels in the tumor center, tumor edge, and healthy tissue.
Methods
This study included a total of 53 patients with head and neck cancer. Samples of 5 × 5 × 5 mm were collected from the tumor center, tumor edge, and the healthy tissue. Total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) values were evaluated. (1) Oxidative stress values in the center and edge of all tumors and in healthy tissues were compared according to localization. (2) Tumors were divided into two groups as malignant (Group 1 [
n
= 28]: Laryngeal and tongue squamous cell cancers) and benign (Group 2 [
n
= 25]: Pleomorphic adenoma and Warthin tumors). The groups were compared according to the localization of the tissues.
Results
The TOS value in the tumor edge was significantly higher than those in the tumor center and the healthy tissue. The TAS value in tissue located in the tumor edge was significantly higher than in the healthy tissue. The OSI value in the tumor edge was significantly higher than those in the tumor center and the healthy tissue.
In all three localizations (tumor center, tumor edge, and healthy tissue), TOS and OSI values in Group 1 were significantly higher than Group 2.
Conclusion
Oxidative stress values in the tumor edge are significantly higher than the center of the tumor and healthy tissue. In malignant tumors, oxidative stress values are significantly higher in all localizations compared to benign tumors.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33811549</pmid><doi>10.1007/s00405-021-06749-x</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-5627-1342</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0937-4477 |
| ispartof | European archives of oto-rhino-laryngology, 2021-12, Vol.278 (12), p.5013-5020 |
| issn | 0937-4477 1434-4726 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2508576380 |
| source | Springer Nature - Complete Springer Journals |
| subjects | Head and Neck Head and Neck Surgery Medicine Medicine & Public Health Neurosurgery Otorhinolaryngology |
| title | Are the oxidative stress levels in the tumor center and tumor boundary different from those in healthy tissue? |
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