Serum Concentration of Antibodies to Mumps, but Not Measles, Rubella, or Varicella, Is Associated with Intake of Dietary Fiber in the NHANES, 1999-2004
Treatment with prebiotics, a type of dietary fiber, was recently shown to increase antibody concentrations following influenza vaccination in a meta-analysis of clinical trials. In observational epidemiologic studies it is not possible to estimate intake of prebiotics, but quantifying intake of diet...
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| description | Treatment with prebiotics, a type of dietary fiber, was recently shown to increase antibody concentrations following influenza vaccination in a meta-analysis of clinical trials. In observational epidemiologic studies it is not possible to estimate intake of prebiotics, but quantifying intake of dietary fiber is routine. Our objective was to investigate the potential effect of dietary fiber on immunogenicity. We examined serum antibody concentrations (Measles, Mumps, Rubella, and Varicella) in relation to dietary fiber in more than 12,000 subjects in the U.S. National Health and Nutrition Examination Survey (NHANES) for the period 1999-2004. Data from one (1999-2002) or two (2003-2004) dietary recalls were used to calculate fiber intake. For Mumps the adjusted percentage difference in antibody concentration per interquartile range intake in energy-adjusted dietary fiber was 6.34% (95% confidence interval, 3.10, 9.68). Fiber from grain-based foods was more positively associated than fiber from other fiber-containing food groups. The association was slightly larger among subgroups with higher fiber intake, greater interquartile range in fiber intake, and less measurement error. Furthermore, based on the reliability of the diet recalls in 2003-2004, we calculated that the percentage difference per interquartile increment was substantially attenuated by measurement error. Dietary fiber may have a favorable influence on the immunogenicity of some vaccines or natural infections. |
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In observational epidemiologic studies it is not possible to estimate intake of prebiotics, but quantifying intake of dietary fiber is routine. Our objective was to investigate the potential effect of dietary fiber on immunogenicity. We examined serum antibody concentrations (Measles, Mumps, Rubella, and Varicella) in relation to dietary fiber in more than 12,000 subjects in the U.S. National Health and Nutrition Examination Survey (NHANES) for the period 1999-2004. Data from one (1999-2002) or two (2003-2004) dietary recalls were used to calculate fiber intake. For Mumps the adjusted percentage difference in antibody concentration per interquartile range intake in energy-adjusted dietary fiber was 6.34% (95% confidence interval, 3.10, 9.68). Fiber from grain-based foods was more positively associated than fiber from other fiber-containing food groups. The association was slightly larger among subgroups with higher fiber intake, greater interquartile range in fiber intake, and less measurement error. Furthermore, based on the reliability of the diet recalls in 2003-2004, we calculated that the percentage difference per interquartile increment was substantially attenuated by measurement error. 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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). 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The association was slightly larger among subgroups with higher fiber intake, greater interquartile range in fiber intake, and less measurement error. Furthermore, based on the reliability of the diet recalls in 2003-2004, we calculated that the percentage difference per interquartile increment was substantially attenuated by measurement error. Dietary fiber may have a favorable influence on the immunogenicity of some vaccines or natural infections.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Antibodies</subject><subject>Antibodies, Viral - blood</subject><subject>Chicken pox</subject><subject>Chickenpox - immunology</subject><subject>Chickenpox - prevention & control</subject><subject>Child</subject><subject>Clinical trials</subject><subject>Confidence intervals</subject><subject>Cross-Sectional Studies</subject><subject>Diet</subject><subject>Dietary Fiber</subject><subject>Dietary intake</subject><subject>Energy</subject><subject>Enzymes</subject><subject>Epidemiologic Studies</subject><subject>Epidemiology</subject><subject>Error analysis</subject><subject>Ethnicity</subject><subject>Family income</subject><subject>Female</subject><subject>Food</subject><subject>Food groups</subject><subject>Humans</subject><subject>Immunogenicity</subject><subject>Immunogenicity, Vaccine</subject><subject>Influenza</subject><subject>Laboratories</subject><subject>Male</subject><subject>Measles</subject><subject>Measles - immunology</subject><subject>Measles - prevention & control</subject><subject>Middle Aged</subject><subject>Mumps</subject><subject>Mumps - immunology</subject><subject>Mumps - prevention & control</subject><subject>Nutrition</subject><subject>Nutrition Surveys</subject><subject>Prebiotics</subject><subject>Public health</subject><subject>Rubella</subject><subject>Rubella - immunology</subject><subject>Rubella - prevention & control</subject><subject>Subgroups</subject><subject>Vaccination</subject><subject>Vaccines</subject><subject>Varicella</subject><subject>Young Adult</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNpdks1uEzEURkcIRKvSDQ-ALLFBKAH_je3ZIEWhpZHaIFFga3k8143DZBxsD1WfhNfFaUpp8cb29dHR9adbVS8JfsdYg98PI2GYYUXYk-qQYkmnQnD29MH5oDpOaY13S2Ip2PPqgDGFCWXysPp9CXHcoHkYLAw5muzDgIJDsyH7NnQeEsoBXYybbZqgdsxoGTK6AJN6KIUvYwt9byYoRPTdRG_3t0VCs5SC9SZDh659XqHFkM0P2Jk_esgm3qBT30JEfkB5BWh5NlueXE4QaZpmSjHmL6pnzvQJju_2o-rb6cnX-dn0_POnxXx2PrVc0jxVHBzHnXIKWy7q8mXJOVGiKAC4AjCdpRTbuquVkK4DqRy3ymDRGGI6wY6qxd7bBbPW2-g3pTcdjNe3hRCvtInZ2x50wylmjSMtriVvJCkSY2jrjOWcOieL68PetR3bDXT7QPtH0scvg1_pq_BLK4yJwjvBmztBDD9HSFlvfLrNdIAwJk1rrGpZS9EU9PV_6DqMcShRFUpQUouakEK93VM2hpQiuPtmCNa78dH_xqfArx62f4_-HRb2ByNZvOQ</recordid><startdate>20210302</startdate><enddate>20210302</enddate><creator>Van Landingham, Cynthia B</creator><creator>Keast, Debra R</creator><creator>Longnecker, Matthew P</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-7262-4400</orcidid></search><sort><creationdate>20210302</creationdate><title>Serum Concentration of Antibodies to Mumps, but Not Measles, Rubella, or Varicella, Is Associated with Intake of Dietary Fiber in the NHANES, 1999-2004</title><author>Van Landingham, Cynthia B ; 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In observational epidemiologic studies it is not possible to estimate intake of prebiotics, but quantifying intake of dietary fiber is routine. Our objective was to investigate the potential effect of dietary fiber on immunogenicity. We examined serum antibody concentrations (Measles, Mumps, Rubella, and Varicella) in relation to dietary fiber in more than 12,000 subjects in the U.S. National Health and Nutrition Examination Survey (NHANES) for the period 1999-2004. Data from one (1999-2002) or two (2003-2004) dietary recalls were used to calculate fiber intake. For Mumps the adjusted percentage difference in antibody concentration per interquartile range intake in energy-adjusted dietary fiber was 6.34% (95% confidence interval, 3.10, 9.68). Fiber from grain-based foods was more positively associated than fiber from other fiber-containing food groups. The association was slightly larger among subgroups with higher fiber intake, greater interquartile range in fiber intake, and less measurement error. Furthermore, based on the reliability of the diet recalls in 2003-2004, we calculated that the percentage difference per interquartile increment was substantially attenuated by measurement error. Dietary fiber may have a favorable influence on the immunogenicity of some vaccines or natural infections.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>33801237</pmid><doi>10.3390/nu13030813</doi><orcidid>https://orcid.org/0000-0001-7262-4400</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Age Antibodies Antibodies, Viral - blood Chicken pox Chickenpox - immunology Chickenpox - prevention & control Child Clinical trials Confidence intervals Cross-Sectional Studies Diet Dietary Fiber Dietary intake Energy Enzymes Epidemiologic Studies Epidemiology Error analysis Ethnicity Family income Female Food Food groups Humans Immunogenicity Immunogenicity, Vaccine Influenza Laboratories Male Measles Measles - immunology Measles - prevention & control Middle Aged Mumps Mumps - immunology Mumps - prevention & control Nutrition Nutrition Surveys Prebiotics Public health Rubella Rubella - immunology Rubella - prevention & control Subgroups Vaccination Vaccines Varicella Young Adult |
| title | Serum Concentration of Antibodies to Mumps, but Not Measles, Rubella, or Varicella, Is Associated with Intake of Dietary Fiber in the NHANES, 1999-2004 |
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