The effect of endothelial Nitric Oxide Synthase G894T and T786C polymorphisms on Hypoxia-Inducible Factor-1 alpha expression in Sickle Cell Disease

Hypoxia-Inducible Factor-1α (HIF-1α) expression is upregulated in Sickle Cell Disease (SCD) and correlates with various laboratory markers of disease severity. Nitric Oxide plays a pivotal role in SCD pathophysiology and endothelial Nitric Oxide Synthase (NOS3) polymorphisms affect prognosis and lab...

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Veröffentlicht in:	Nitric oxide 2021-06, Vol.111-112, p.31-36
Hauptverfasser:	Armenis, Iakovos, Kalotychou, Vassiliki, Tzanetea, Revekka, Konstantopoulos, Kostas, Rombos, Ioannis
Format:	Artikel
Sprache:	eng
Schlagworte:	Endothelial nitric oxide synthase G894T polymorphism HIF-1α Hypoxia Sickle cell disease
Online-Zugang:	Volltext
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