Antibody deficiencies are more common in adult versus pediatric recurrent acute rhinosinusitis
To evaluate the frequency and types of humoral immunodeficiencies (HID) in pediatric and adult patients with recurrent (RARS). Patients with HID commonly present with upper respiratory tract infections. Their pathophysiology in children is different than adult counterparts. It is unknown how HID aff...
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| Veröffentlicht in: | American journal of otolaryngology 2021-09, Vol.42 (5), p.103004-103004, Article 103004 |
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| container_title | American journal of otolaryngology |
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| creator | Makary, Chadi A. Purnell, Phillip R. O'Brien, Daniel Chaiban, Rafka Demirdağ, Yeşim Yılmaz Ramadan, Hassan |
| description | To evaluate the frequency and types of humoral immunodeficiencies (HID) in pediatric and adult patients with recurrent (RARS). Patients with HID commonly present with upper respiratory tract infections. Their pathophysiology in children is different than adult counterparts. It is unknown how HID affects those two age groups.
We performed a retrospective chart review of pediatric (3 times/year) rhinosinusitis. Patients with cystic fibrosis, Aspirin Exacerbated Respiratory Disease (AERD), and ciliary dyskinesia were excluded. Demographic data and associated conditions were reviewed. Immunologic evaluation included complete blood cell count (CBC) with differential, serum immunoglobulin G, A, and M levels, and baseline and post-vaccination pneumococcal antibody titers.
There were 135 patients who met the inclusion criteria. 86 patients (63.7%) were children, 49 patients (36.3%) were adults. 46.5% of the pediatric patients and 45% of the adult patients were female. 17.4% of children had abnormal immunologic findings: 8 had hypogammaglobulinemia (p |
| doi_str_mv | 10.1016/j.amjoto.2021.103004 |
| format | Article |
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We performed a retrospective chart review of pediatric (<18 years old) and adult (18 years and older) patients who were evaluated in our pediatric and adult rhinology clinic between July 2010 and December 2020 and had the diagnosis of recurrent (>3 times/year) rhinosinusitis. Patients with cystic fibrosis, Aspirin Exacerbated Respiratory Disease (AERD), and ciliary dyskinesia were excluded. Demographic data and associated conditions were reviewed. Immunologic evaluation included complete blood cell count (CBC) with differential, serum immunoglobulin G, A, and M levels, and baseline and post-vaccination pneumococcal antibody titers.
There were 135 patients who met the inclusion criteria. 86 patients (63.7%) were children, 49 patients (36.3%) were adults. 46.5% of the pediatric patients and 45% of the adult patients were female. 17.4% of children had abnormal immunologic findings: 8 had hypogammaglobulinemia (p < 0.0001), 2 had specific antibody deficiency (SAD), and 5 had selective IgA deficiency. 32.7% of adults (p < 0.0001) had abnormal immunologic findings: 4 had hypogammaglobulinemia, 11 had SAD (p < 0.0001), and 1 patient had both IgA deficiency and SAD.
Humoral immunodeficiency, specifically SAD, seems to be more common in adult versus pediatric RARS that is refractory to treatment.</description><identifier>ISSN: 0196-0709</identifier><identifier>EISSN: 1532-818X</identifier><identifier>DOI: 10.1016/j.amjoto.2021.103004</identifier><identifier>PMID: 33812207</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acute Disease ; Adolescent ; Adult ; Adults ; Age ; Age Factors ; Aged ; Aged, 80 and over ; Antibiotics ; Antibodies ; Antibody deficiency ; Aspirin ; Asthma ; Blood cells ; Child ; Children ; Chronic illnesses ; Cystic fibrosis ; Disease prevention ; Dyskinesia ; Female ; Humans ; Hypogammaglobulinemia ; IgG antibody ; Immune system ; Immunity, Humoral ; Immunodeficiencies ; Immunodeficiency ; Immunoglobulin A ; Immunoglobulin G ; Immunoglobulins ; Immunoglobulins - blood ; Immunologic Deficiency Syndromes - complications ; Immunologic Deficiency Syndromes - epidemiology ; Immunologic Deficiency Syndromes - immunology ; Infections ; Male ; Middle Aged ; Otolaryngology ; Patients ; Pediatrics ; Population ; Recurrence ; Recurrent acute rhinosinusitis ; Respiratory diseases ; Respiratory tract ; Respiratory tract diseases ; Retrospective Studies ; Rhinitis ; Rhinitis - epidemiology ; Rhinitis - etiology ; Rhinitis - immunology ; Rhinosinusitis ; Sinusitis ; Sinusitis - epidemiology ; Sinusitis - etiology ; Sinusitis - immunology ; Steroids ; Upper respiratory tract infections ; Vaccination ; Vaccines ; Young Adult</subject><ispartof>American journal of otolaryngology, 2021-09, Vol.42 (5), p.103004-103004, Article 103004</ispartof><rights>2021 Elsevier Inc.</rights><rights>Copyright © 2021 Elsevier Inc. All rights reserved.</rights><rights>2021. Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-445fdf1e091e97615f9d9f5184a25816168f4006ae31262d4382e60ee9ce4883</citedby><cites>FETCH-LOGICAL-c390t-445fdf1e091e97615f9d9f5184a25816168f4006ae31262d4382e60ee9ce4883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.amjoto.2021.103004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27926,27927,45997</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33812207$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Makary, Chadi A.</creatorcontrib><creatorcontrib>Purnell, Phillip R.</creatorcontrib><creatorcontrib>O'Brien, Daniel</creatorcontrib><creatorcontrib>Chaiban, Rafka</creatorcontrib><creatorcontrib>Demirdağ, Yeşim Yılmaz</creatorcontrib><creatorcontrib>Ramadan, Hassan</creatorcontrib><title>Antibody deficiencies are more common in adult versus pediatric recurrent acute rhinosinusitis</title><title>American journal of otolaryngology</title><addtitle>Am J Otolaryngol</addtitle><description>To evaluate the frequency and types of humoral immunodeficiencies (HID) in pediatric and adult patients with recurrent (RARS). Patients with HID commonly present with upper respiratory tract infections. Their pathophysiology in children is different than adult counterparts. It is unknown how HID affects those two age groups.
We performed a retrospective chart review of pediatric (<18 years old) and adult (18 years and older) patients who were evaluated in our pediatric and adult rhinology clinic between July 2010 and December 2020 and had the diagnosis of recurrent (>3 times/year) rhinosinusitis. Patients with cystic fibrosis, Aspirin Exacerbated Respiratory Disease (AERD), and ciliary dyskinesia were excluded. Demographic data and associated conditions were reviewed. Immunologic evaluation included complete blood cell count (CBC) with differential, serum immunoglobulin G, A, and M levels, and baseline and post-vaccination pneumococcal antibody titers.
There were 135 patients who met the inclusion criteria. 86 patients (63.7%) were children, 49 patients (36.3%) were adults. 46.5% of the pediatric patients and 45% of the adult patients were female. 17.4% of children had abnormal immunologic findings: 8 had hypogammaglobulinemia (p < 0.0001), 2 had specific antibody deficiency (SAD), and 5 had selective IgA deficiency. 32.7% of adults (p < 0.0001) had abnormal immunologic findings: 4 had hypogammaglobulinemia, 11 had SAD (p < 0.0001), and 1 patient had both IgA deficiency and SAD.
Humoral immunodeficiency, specifically SAD, seems to be more common in adult versus pediatric RARS that is refractory to treatment.</description><subject>Acute Disease</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Adults</subject><subject>Age</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antibiotics</subject><subject>Antibodies</subject><subject>Antibody deficiency</subject><subject>Aspirin</subject><subject>Asthma</subject><subject>Blood cells</subject><subject>Child</subject><subject>Children</subject><subject>Chronic illnesses</subject><subject>Cystic fibrosis</subject><subject>Disease prevention</subject><subject>Dyskinesia</subject><subject>Female</subject><subject>Humans</subject><subject>Hypogammaglobulinemia</subject><subject>IgG antibody</subject><subject>Immune system</subject><subject>Immunity, Humoral</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiency</subject><subject>Immunoglobulin A</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulins</subject><subject>Immunoglobulins - blood</subject><subject>Immunologic Deficiency Syndromes - complications</subject><subject>Immunologic Deficiency Syndromes - epidemiology</subject><subject>Immunologic Deficiency Syndromes - immunology</subject><subject>Infections</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Otolaryngology</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Population</subject><subject>Recurrence</subject><subject>Recurrent acute rhinosinusitis</subject><subject>Respiratory diseases</subject><subject>Respiratory tract</subject><subject>Respiratory tract diseases</subject><subject>Retrospective Studies</subject><subject>Rhinitis</subject><subject>Rhinitis - epidemiology</subject><subject>Rhinitis - etiology</subject><subject>Rhinitis - immunology</subject><subject>Rhinosinusitis</subject><subject>Sinusitis</subject><subject>Sinusitis - epidemiology</subject><subject>Sinusitis - etiology</subject><subject>Sinusitis - immunology</subject><subject>Steroids</subject><subject>Upper respiratory tract infections</subject><subject>Vaccination</subject><subject>Vaccines</subject><subject>Young Adult</subject><issn>0196-0709</issn><issn>1532-818X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtrFTEUgIMo9vbqPxAJuHEz15PHZDIboRStQsFNF64MaXIGM9yZXPMo9N83daoLFy7OOXD4zoOPkDcMDgyY-jAf7DLHEg8cOGstASCfkR3rBe8009-fkx2wUXUwwHhGznOeAUBI0b8kZ0JoxjkMO_LjYi3hNvp76nEKLuDaIlObkC6xJReXJa40rNT6eiz0DlOumZ7QB1tScDShqynhWqh1tSBNP8Mac1hrDiXkV-TFZI8ZXz_VPbn5_Onm8kt3_e3q6-XFdefECKWTsp_8xBBGhuOgWD-Nfpx6pqXlvWaKKT1JAGVRMK64l0JzVIA4OpRaiz15v609pfirYi5mCdnh8WhXjDUb3oPuldZ8aOi7f9A51rS25xqlhNQDNIV7IjfKpZhzwsmcUlhsujcMzKN-M5tNv3nUbzb9bezt0_J6u6D_O_THdwM-bgA2GXcBk8m_nTedTWQxPob_X3gAojGXtQ</recordid><startdate>202109</startdate><enddate>202109</enddate><creator>Makary, Chadi A.</creator><creator>Purnell, Phillip R.</creator><creator>O'Brien, Daniel</creator><creator>Chaiban, Rafka</creator><creator>Demirdağ, Yeşim Yılmaz</creator><creator>Ramadan, Hassan</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>202109</creationdate><title>Antibody deficiencies are more common in adult versus pediatric recurrent acute rhinosinusitis</title><author>Makary, Chadi A. ; Purnell, Phillip R. ; O'Brien, Daniel ; Chaiban, Rafka ; Demirdağ, Yeşim Yılmaz ; Ramadan, Hassan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-445fdf1e091e97615f9d9f5184a25816168f4006ae31262d4382e60ee9ce4883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acute Disease</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Adults</topic><topic>Age</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antibiotics</topic><topic>Antibodies</topic><topic>Antibody deficiency</topic><topic>Aspirin</topic><topic>Asthma</topic><topic>Blood cells</topic><topic>Child</topic><topic>Children</topic><topic>Chronic illnesses</topic><topic>Cystic fibrosis</topic><topic>Disease prevention</topic><topic>Dyskinesia</topic><topic>Female</topic><topic>Humans</topic><topic>Hypogammaglobulinemia</topic><topic>IgG antibody</topic><topic>Immune system</topic><topic>Immunity, Humoral</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiency</topic><topic>Immunoglobulin A</topic><topic>Immunoglobulin G</topic><topic>Immunoglobulins</topic><topic>Immunoglobulins - blood</topic><topic>Immunologic Deficiency Syndromes - complications</topic><topic>Immunologic Deficiency Syndromes - epidemiology</topic><topic>Immunologic Deficiency Syndromes - immunology</topic><topic>Infections</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Otolaryngology</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Population</topic><topic>Recurrence</topic><topic>Recurrent acute rhinosinusitis</topic><topic>Respiratory diseases</topic><topic>Respiratory tract</topic><topic>Respiratory tract diseases</topic><topic>Retrospective Studies</topic><topic>Rhinitis</topic><topic>Rhinitis - epidemiology</topic><topic>Rhinitis - etiology</topic><topic>Rhinitis - immunology</topic><topic>Rhinosinusitis</topic><topic>Sinusitis</topic><topic>Sinusitis - epidemiology</topic><topic>Sinusitis - etiology</topic><topic>Sinusitis - immunology</topic><topic>Steroids</topic><topic>Upper respiratory tract infections</topic><topic>Vaccination</topic><topic>Vaccines</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Makary, Chadi A.</creatorcontrib><creatorcontrib>Purnell, Phillip R.</creatorcontrib><creatorcontrib>O'Brien, Daniel</creatorcontrib><creatorcontrib>Chaiban, Rafka</creatorcontrib><creatorcontrib>Demirdağ, Yeşim Yılmaz</creatorcontrib><creatorcontrib>Ramadan, Hassan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of otolaryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Makary, Chadi A.</au><au>Purnell, Phillip R.</au><au>O'Brien, Daniel</au><au>Chaiban, Rafka</au><au>Demirdağ, Yeşim Yılmaz</au><au>Ramadan, Hassan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibody deficiencies are more common in adult versus pediatric recurrent acute rhinosinusitis</atitle><jtitle>American journal of otolaryngology</jtitle><addtitle>Am J Otolaryngol</addtitle><date>2021-09</date><risdate>2021</risdate><volume>42</volume><issue>5</issue><spage>103004</spage><epage>103004</epage><pages>103004-103004</pages><artnum>103004</artnum><issn>0196-0709</issn><eissn>1532-818X</eissn><abstract>To evaluate the frequency and types of humoral immunodeficiencies (HID) in pediatric and adult patients with recurrent (RARS). Patients with HID commonly present with upper respiratory tract infections. Their pathophysiology in children is different than adult counterparts. It is unknown how HID affects those two age groups.
We performed a retrospective chart review of pediatric (<18 years old) and adult (18 years and older) patients who were evaluated in our pediatric and adult rhinology clinic between July 2010 and December 2020 and had the diagnosis of recurrent (>3 times/year) rhinosinusitis. Patients with cystic fibrosis, Aspirin Exacerbated Respiratory Disease (AERD), and ciliary dyskinesia were excluded. Demographic data and associated conditions were reviewed. Immunologic evaluation included complete blood cell count (CBC) with differential, serum immunoglobulin G, A, and M levels, and baseline and post-vaccination pneumococcal antibody titers.
There were 135 patients who met the inclusion criteria. 86 patients (63.7%) were children, 49 patients (36.3%) were adults. 46.5% of the pediatric patients and 45% of the adult patients were female. 17.4% of children had abnormal immunologic findings: 8 had hypogammaglobulinemia (p < 0.0001), 2 had specific antibody deficiency (SAD), and 5 had selective IgA deficiency. 32.7% of adults (p < 0.0001) had abnormal immunologic findings: 4 had hypogammaglobulinemia, 11 had SAD (p < 0.0001), and 1 patient had both IgA deficiency and SAD.
Humoral immunodeficiency, specifically SAD, seems to be more common in adult versus pediatric RARS that is refractory to treatment.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>33812207</pmid><doi>10.1016/j.amjoto.2021.103004</doi><tpages>1</tpages></addata></record> |
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| subjects | Acute Disease Adolescent Adult Adults Age Age Factors Aged Aged, 80 and over Antibiotics Antibodies Antibody deficiency Aspirin Asthma Blood cells Child Children Chronic illnesses Cystic fibrosis Disease prevention Dyskinesia Female Humans Hypogammaglobulinemia IgG antibody Immune system Immunity, Humoral Immunodeficiencies Immunodeficiency Immunoglobulin A Immunoglobulin G Immunoglobulins Immunoglobulins - blood Immunologic Deficiency Syndromes - complications Immunologic Deficiency Syndromes - epidemiology Immunologic Deficiency Syndromes - immunology Infections Male Middle Aged Otolaryngology Patients Pediatrics Population Recurrence Recurrent acute rhinosinusitis Respiratory diseases Respiratory tract Respiratory tract diseases Retrospective Studies Rhinitis Rhinitis - epidemiology Rhinitis - etiology Rhinitis - immunology Rhinosinusitis Sinusitis Sinusitis - epidemiology Sinusitis - etiology Sinusitis - immunology Steroids Upper respiratory tract infections Vaccination Vaccines Young Adult |
| title | Antibody deficiencies are more common in adult versus pediatric recurrent acute rhinosinusitis |
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