Design and synthesis of novel coumarin derivatives as potential acetylcholinesterase inhibitors for Alzheimer's disease

[Display omitted] •Twenty 7-benzyloxycoumarin based compounds were synthesized as AChEIs.•Compound 5b exhibited promising AChE inhibitory activity better than donepezil.•Kinetic study for compound 5b implied mixed type inhibitor.•In vivo evaluation of compounds 5b, 13c and 16a were carried out.•Comp...

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Veröffentlicht in:	Bioorganic chemistry 2021-05, Vol.110, p.104792-104792, Article 104792
Hauptverfasser:	Amin, Kamilia M., Abdel Rahman, Doaa E., Abdelrasheed Allam, Heba, El-Zoheiry, Haidy H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase Alzheimer’s disease Coumarin Neuroprotective
Online-Zugang:	Volltext
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