Highly Regioselective and Chemoselective [3 + 3] Annulation of Enaminones with ortho-Fluoronitrobenzenenes: Divergent Synthesis of Aposafranones and Their N‑Oxides

Highly Regioselective and Chemoselective [3 + 3] Annulation of Enaminones with ortho-Fluoronitrobenzenenes: Divergent Synthesis of Aposafranones and Their N‑Oxides

A base-promoted unprecedented strategy for the regioselective and chemoselective divergent synthesis of highly functionalized aposafranones and their N-oxides has been developed from the [3 + 3] annulation of enaminones with o-fluoronitrobenzenenes. This novel synthetic strategy offers an alternativ...

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Veröffentlicht in:Organic letters 2021-04, Vol.23 (8), p.3032-3037
Hauptverfasser: Chen, Xue-Bing, Huang, Shun-Tao, Li, Jie, Yang, Qi, Yang, Li, Yu, Fuchao
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container_end_page 3037
container_issue 8
container_start_page 3032
container_title Organic letters
container_volume 23
creator Chen, Xue-Bing
Huang, Shun-Tao
Li, Jie
Yang, Qi
Yang, Li
Yu, Fuchao
description A base-promoted unprecedented strategy for the regioselective and chemoselective divergent synthesis of highly functionalized aposafranones and their N-oxides has been developed from the [3 + 3] annulation of enaminones with o-fluoronitrobenzenenes. This novel synthetic strategy offers an alternative method for the construction of aposafranones and their N-oxides are meaningful in the fields of both biology and organic synthesis. The established protocol explores the annulation scope of enaminones, and it expands the application of nitro-based cyclization.
doi_str_mv 10.1021/acs.orglett.1c00710
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title Highly Regioselective and Chemoselective [3 + 3] Annulation of Enaminones with ortho-Fluoronitrobenzenenes: Divergent Synthesis of Aposafranones and Their N‑Oxides
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