Telomere length is independently associated with all-cause mortality in chronic heart failure
ObjectivePatients with heart failure have shorter mean leucocyte telomere length (LTL), a marker of biological age, compared with healthy subjects, but it is unclear whether this is of prognostic significance. We therefore sought to determine whether LTL is associated with outcomes in patients with...
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| Veröffentlicht in: | Heart (British Cardiac Society) 2022-01, Vol.108 (2), p.124-129 |
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| creator | Romaine, Simon P R Denniff, Matthew Codd, Veryan Nath, Mintu Koekemoer, Andrea Anker, Stefan D Cleland, John G Filippatos, Gerasimos Levin, Daniel Metra, Marco Mordi, Ify R Ouwerkerk, Wouter ter Maaten, Jozine M van Veldhuisen, Dirk J Zannad, Faiez Ng, Leong L van der Harst, Pim Lang, Chim C Voors, Adriaan A Nelson, Christopher P Samani, Nilesh J |
| description | ObjectivePatients with heart failure have shorter mean leucocyte telomere length (LTL), a marker of biological age, compared with healthy subjects, but it is unclear whether this is of prognostic significance. We therefore sought to determine whether LTL is associated with outcomes in patients with heart failure.MethodsWe measured LTL in patients with heart failure from the BIOSTAT-CHF Index (n=2260) and BIOSTAT-CHF Tayside (n=1413) cohorts. Cox proportional hazards analyses were performed individually in each cohort and the estimates combined using meta-analysis. Our co-primary endpoints were all-cause mortality and heart failure hospitalisation.ResultsIn age-adjusted and sex-adjusted analyses, shorter LTL was associated with higher all-cause mortality in both cohorts individually and when combined (meta-analysis HR (per SD decrease in LTL)=1.16 (95% CI 1.08 to 1.24); p=2.66×10−5), an effect equivalent to that of being four years older. The association remained significant after adjustment for the BIOSTAT-CHF clinical risk score to account for known prognostic factors (HR=1.12 (95% CI 1.05 to 1.20); p=1.04×10−3). Shorter LTL was associated with both cardiovascular (HR=1.09 (95% CI 1.00 to 1.19); p=0.047) and non-cardiovascular deaths (HR=1.18 (95% CI 1.05 to 1.32); p=4.80×10−3). There was no association between LTL and heart failure hospitalisation (HR=0.99 (95% CI 0.92 to 1.07); p=0.855).ConclusionIn patients with heart failure, shorter mean LTL is independently associated with all-cause mortality. |
| doi_str_mv | 10.1136/heartjnl-2020-318654 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2507728274</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2612597179</sourcerecordid><originalsourceid>FETCH-LOGICAL-b462t-d8d87ab3cd366acb2e2552e64e99037aa05dc3d511a5deddae4b172c6ebd153d3</originalsourceid><addsrcrecordid>eNqNkEtLxDAYRYMoPkb_gUjAjZtqHk3SLkV8geBGwY2ENPnGyZC2Y9Ii8--Njo7gQtwkIZx7uRyEDik5pZTLsxmYOMy7UDDCSMFpJUW5gXZpKav8RZ8285sLUUjC1Q7aS2lOCCnrSm6jHc5VVdeK76LnBwh9CxFwgO5lmGGfsO8cLCAf3RCW2KTUW28GcPjNZ8CEUFgzJsBtHwcT_LDMCWxnse-8xZ-z8NT4MEbYR1tTExIcfN0T9Hh1-XBxU9zdX99enN8VTSnZULjKVco03DoupbENAyYEA1lCXef1xhDhLHeCUiMcOGegbKhiVkLjqOCOT9DJqncR-9cR0qBbnyyEYDrox6SZIEqxiqkyo8e_0Hk_xi6v00xSJmpFVZ2pckXZ2KcUYaoX0bcmLjUl-kO__tavP_Trlf4cO_oqH5sW3Dr07TsDZyugaef_rSQ_ifXUPyPvytmjIg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2612597179</pqid></control><display><type>article</type><title>Telomere length is independently associated with all-cause mortality in chronic heart failure</title><source>MEDLINE</source><source>PubMed Central</source><creator>Romaine, Simon P R ; Denniff, Matthew ; Codd, Veryan ; Nath, Mintu ; Koekemoer, Andrea ; Anker, Stefan D ; Cleland, John G ; Filippatos, Gerasimos ; Levin, Daniel ; Metra, Marco ; Mordi, Ify R ; Ouwerkerk, Wouter ; ter Maaten, Jozine M ; van Veldhuisen, Dirk J ; Zannad, Faiez ; Ng, Leong L ; van der Harst, Pim ; Lang, Chim C ; Voors, Adriaan A ; Nelson, Christopher P ; Samani, Nilesh J</creator><creatorcontrib>Romaine, Simon P R ; Denniff, Matthew ; Codd, Veryan ; Nath, Mintu ; Koekemoer, Andrea ; Anker, Stefan D ; Cleland, John G ; Filippatos, Gerasimos ; Levin, Daniel ; Metra, Marco ; Mordi, Ify R ; Ouwerkerk, Wouter ; ter Maaten, Jozine M ; van Veldhuisen, Dirk J ; Zannad, Faiez ; Ng, Leong L ; van der Harst, Pim ; Lang, Chim C ; Voors, Adriaan A ; Nelson, Christopher P ; Samani, Nilesh J</creatorcontrib><description>ObjectivePatients with heart failure have shorter mean leucocyte telomere length (LTL), a marker of biological age, compared with healthy subjects, but it is unclear whether this is of prognostic significance. We therefore sought to determine whether LTL is associated with outcomes in patients with heart failure.MethodsWe measured LTL in patients with heart failure from the BIOSTAT-CHF Index (n=2260) and BIOSTAT-CHF Tayside (n=1413) cohorts. Cox proportional hazards analyses were performed individually in each cohort and the estimates combined using meta-analysis. Our co-primary endpoints were all-cause mortality and heart failure hospitalisation.ResultsIn age-adjusted and sex-adjusted analyses, shorter LTL was associated with higher all-cause mortality in both cohorts individually and when combined (meta-analysis HR (per SD decrease in LTL)=1.16 (95% CI 1.08 to 1.24); p=2.66×10−5), an effect equivalent to that of being four years older. The association remained significant after adjustment for the BIOSTAT-CHF clinical risk score to account for known prognostic factors (HR=1.12 (95% CI 1.05 to 1.20); p=1.04×10−3). Shorter LTL was associated with both cardiovascular (HR=1.09 (95% CI 1.00 to 1.19); p=0.047) and non-cardiovascular deaths (HR=1.18 (95% CI 1.05 to 1.32); p=4.80×10−3). There was no association between LTL and heart failure hospitalisation (HR=0.99 (95% CI 0.92 to 1.07); p=0.855).ConclusionIn patients with heart failure, shorter mean LTL is independently associated with all-cause mortality.</description><identifier>ISSN: 1355-6037</identifier><identifier>EISSN: 1468-201X</identifier><identifier>DOI: 10.1136/heartjnl-2020-318654</identifier><identifier>PMID: 33789973</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and British Cardiovascular Society</publisher><subject>Age ; Beta blockers ; biomarkers ; Body mass index ; Cell division ; Chronic Disease ; Cohort Studies ; Diuretics ; Ejection fraction ; genetics ; Heart failure ; Heart Failure - diagnosis ; Heart Failure - genetics ; Heart failure and cardiomyopathies ; Hospitalization ; Humans ; Ischemia ; Laboratories ; Leukocytes ; Medical prognosis ; Mortality ; Patients ; Peptides ; Regression analysis ; Risk Factors ; Telomerase ; Telomere - genetics ; Variables</subject><ispartof>Heart (British Cardiac Society), 2022-01, Vol.108 (2), p.124-129</ispartof><rights>Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2022 Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b462t-d8d87ab3cd366acb2e2552e64e99037aa05dc3d511a5deddae4b172c6ebd153d3</citedby><cites>FETCH-LOGICAL-b462t-d8d87ab3cd366acb2e2552e64e99037aa05dc3d511a5deddae4b172c6ebd153d3</cites><orcidid>0000-0003-4732-7572 ; 0000-0002-1471-7016 ; 0000-0002-5417-4415</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33789973$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Romaine, Simon P R</creatorcontrib><creatorcontrib>Denniff, Matthew</creatorcontrib><creatorcontrib>Codd, Veryan</creatorcontrib><creatorcontrib>Nath, Mintu</creatorcontrib><creatorcontrib>Koekemoer, Andrea</creatorcontrib><creatorcontrib>Anker, Stefan D</creatorcontrib><creatorcontrib>Cleland, John G</creatorcontrib><creatorcontrib>Filippatos, Gerasimos</creatorcontrib><creatorcontrib>Levin, Daniel</creatorcontrib><creatorcontrib>Metra, Marco</creatorcontrib><creatorcontrib>Mordi, Ify R</creatorcontrib><creatorcontrib>Ouwerkerk, Wouter</creatorcontrib><creatorcontrib>ter Maaten, Jozine M</creatorcontrib><creatorcontrib>van Veldhuisen, Dirk J</creatorcontrib><creatorcontrib>Zannad, Faiez</creatorcontrib><creatorcontrib>Ng, Leong L</creatorcontrib><creatorcontrib>van der Harst, Pim</creatorcontrib><creatorcontrib>Lang, Chim C</creatorcontrib><creatorcontrib>Voors, Adriaan A</creatorcontrib><creatorcontrib>Nelson, Christopher P</creatorcontrib><creatorcontrib>Samani, Nilesh J</creatorcontrib><title>Telomere length is independently associated with all-cause mortality in chronic heart failure</title><title>Heart (British Cardiac Society)</title><addtitle>Heart</addtitle><addtitle>Heart</addtitle><description>ObjectivePatients with heart failure have shorter mean leucocyte telomere length (LTL), a marker of biological age, compared with healthy subjects, but it is unclear whether this is of prognostic significance. We therefore sought to determine whether LTL is associated with outcomes in patients with heart failure.MethodsWe measured LTL in patients with heart failure from the BIOSTAT-CHF Index (n=2260) and BIOSTAT-CHF Tayside (n=1413) cohorts. Cox proportional hazards analyses were performed individually in each cohort and the estimates combined using meta-analysis. Our co-primary endpoints were all-cause mortality and heart failure hospitalisation.ResultsIn age-adjusted and sex-adjusted analyses, shorter LTL was associated with higher all-cause mortality in both cohorts individually and when combined (meta-analysis HR (per SD decrease in LTL)=1.16 (95% CI 1.08 to 1.24); p=2.66×10−5), an effect equivalent to that of being four years older. The association remained significant after adjustment for the BIOSTAT-CHF clinical risk score to account for known prognostic factors (HR=1.12 (95% CI 1.05 to 1.20); p=1.04×10−3). Shorter LTL was associated with both cardiovascular (HR=1.09 (95% CI 1.00 to 1.19); p=0.047) and non-cardiovascular deaths (HR=1.18 (95% CI 1.05 to 1.32); p=4.80×10−3). There was no association between LTL and heart failure hospitalisation (HR=0.99 (95% CI 0.92 to 1.07); p=0.855).ConclusionIn patients with heart failure, shorter mean LTL is independently associated with all-cause mortality.</description><subject>Age</subject><subject>Beta blockers</subject><subject>biomarkers</subject><subject>Body mass index</subject><subject>Cell division</subject><subject>Chronic Disease</subject><subject>Cohort Studies</subject><subject>Diuretics</subject><subject>Ejection fraction</subject><subject>genetics</subject><subject>Heart failure</subject><subject>Heart Failure - diagnosis</subject><subject>Heart Failure - genetics</subject><subject>Heart failure and cardiomyopathies</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Ischemia</subject><subject>Laboratories</subject><subject>Leukocytes</subject><subject>Medical prognosis</subject><subject>Mortality</subject><subject>Patients</subject><subject>Peptides</subject><subject>Regression analysis</subject><subject>Risk Factors</subject><subject>Telomerase</subject><subject>Telomere - genetics</subject><subject>Variables</subject><issn>1355-6037</issn><issn>1468-201X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkEtLxDAYRYMoPkb_gUjAjZtqHk3SLkV8geBGwY2ENPnGyZC2Y9Ii8--Njo7gQtwkIZx7uRyEDik5pZTLsxmYOMy7UDDCSMFpJUW5gXZpKav8RZ8285sLUUjC1Q7aS2lOCCnrSm6jHc5VVdeK76LnBwh9CxFwgO5lmGGfsO8cLCAf3RCW2KTUW28GcPjNZ8CEUFgzJsBtHwcT_LDMCWxnse-8xZ-z8NT4MEbYR1tTExIcfN0T9Hh1-XBxU9zdX99enN8VTSnZULjKVco03DoupbENAyYEA1lCXef1xhDhLHeCUiMcOGegbKhiVkLjqOCOT9DJqncR-9cR0qBbnyyEYDrox6SZIEqxiqkyo8e_0Hk_xi6v00xSJmpFVZ2pckXZ2KcUYaoX0bcmLjUl-kO__tavP_Trlf4cO_oqH5sW3Dr07TsDZyugaef_rSQ_ifXUPyPvytmjIg</recordid><startdate>20220101</startdate><enddate>20220101</enddate><creator>Romaine, Simon P R</creator><creator>Denniff, Matthew</creator><creator>Codd, Veryan</creator><creator>Nath, Mintu</creator><creator>Koekemoer, Andrea</creator><creator>Anker, Stefan D</creator><creator>Cleland, John G</creator><creator>Filippatos, Gerasimos</creator><creator>Levin, Daniel</creator><creator>Metra, Marco</creator><creator>Mordi, Ify R</creator><creator>Ouwerkerk, Wouter</creator><creator>ter Maaten, Jozine M</creator><creator>van Veldhuisen, Dirk J</creator><creator>Zannad, Faiez</creator><creator>Ng, Leong L</creator><creator>van der Harst, Pim</creator><creator>Lang, Chim C</creator><creator>Voors, Adriaan A</creator><creator>Nelson, Christopher P</creator><creator>Samani, Nilesh J</creator><general>BMJ Publishing Group Ltd and British Cardiovascular Society</general><general>BMJ Publishing Group LTD</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4732-7572</orcidid><orcidid>https://orcid.org/0000-0002-1471-7016</orcidid><orcidid>https://orcid.org/0000-0002-5417-4415</orcidid></search><sort><creationdate>20220101</creationdate><title>Telomere length is independently associated with all-cause mortality in chronic heart failure</title><author>Romaine, Simon P R ; Denniff, Matthew ; Codd, Veryan ; Nath, Mintu ; Koekemoer, Andrea ; Anker, Stefan D ; Cleland, John G ; Filippatos, Gerasimos ; Levin, Daniel ; Metra, Marco ; Mordi, Ify R ; Ouwerkerk, Wouter ; ter Maaten, Jozine M ; van Veldhuisen, Dirk J ; Zannad, Faiez ; Ng, Leong L ; van der Harst, Pim ; Lang, Chim C ; Voors, Adriaan A ; Nelson, Christopher P ; Samani, Nilesh J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b462t-d8d87ab3cd366acb2e2552e64e99037aa05dc3d511a5deddae4b172c6ebd153d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Age</topic><topic>Beta blockers</topic><topic>biomarkers</topic><topic>Body mass index</topic><topic>Cell division</topic><topic>Chronic Disease</topic><topic>Cohort Studies</topic><topic>Diuretics</topic><topic>Ejection fraction</topic><topic>genetics</topic><topic>Heart failure</topic><topic>Heart Failure - diagnosis</topic><topic>Heart Failure - genetics</topic><topic>Heart failure and cardiomyopathies</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Ischemia</topic><topic>Laboratories</topic><topic>Leukocytes</topic><topic>Medical prognosis</topic><topic>Mortality</topic><topic>Patients</topic><topic>Peptides</topic><topic>Regression analysis</topic><topic>Risk Factors</topic><topic>Telomerase</topic><topic>Telomere - genetics</topic><topic>Variables</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Romaine, Simon P R</creatorcontrib><creatorcontrib>Denniff, Matthew</creatorcontrib><creatorcontrib>Codd, Veryan</creatorcontrib><creatorcontrib>Nath, Mintu</creatorcontrib><creatorcontrib>Koekemoer, Andrea</creatorcontrib><creatorcontrib>Anker, Stefan D</creatorcontrib><creatorcontrib>Cleland, John G</creatorcontrib><creatorcontrib>Filippatos, Gerasimos</creatorcontrib><creatorcontrib>Levin, Daniel</creatorcontrib><creatorcontrib>Metra, Marco</creatorcontrib><creatorcontrib>Mordi, Ify R</creatorcontrib><creatorcontrib>Ouwerkerk, Wouter</creatorcontrib><creatorcontrib>ter Maaten, Jozine M</creatorcontrib><creatorcontrib>van Veldhuisen, Dirk J</creatorcontrib><creatorcontrib>Zannad, Faiez</creatorcontrib><creatorcontrib>Ng, Leong L</creatorcontrib><creatorcontrib>van der Harst, Pim</creatorcontrib><creatorcontrib>Lang, Chim C</creatorcontrib><creatorcontrib>Voors, Adriaan A</creatorcontrib><creatorcontrib>Nelson, Christopher P</creatorcontrib><creatorcontrib>Samani, Nilesh J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Heart (British Cardiac Society)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Romaine, Simon P R</au><au>Denniff, Matthew</au><au>Codd, Veryan</au><au>Nath, Mintu</au><au>Koekemoer, Andrea</au><au>Anker, Stefan D</au><au>Cleland, John G</au><au>Filippatos, Gerasimos</au><au>Levin, Daniel</au><au>Metra, Marco</au><au>Mordi, Ify R</au><au>Ouwerkerk, Wouter</au><au>ter Maaten, Jozine M</au><au>van Veldhuisen, Dirk J</au><au>Zannad, Faiez</au><au>Ng, Leong L</au><au>van der Harst, Pim</au><au>Lang, Chim C</au><au>Voors, Adriaan A</au><au>Nelson, Christopher P</au><au>Samani, Nilesh J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Telomere length is independently associated with all-cause mortality in chronic heart failure</atitle><jtitle>Heart (British Cardiac Society)</jtitle><stitle>Heart</stitle><addtitle>Heart</addtitle><date>2022-01-01</date><risdate>2022</risdate><volume>108</volume><issue>2</issue><spage>124</spage><epage>129</epage><pages>124-129</pages><issn>1355-6037</issn><eissn>1468-201X</eissn><abstract>ObjectivePatients with heart failure have shorter mean leucocyte telomere length (LTL), a marker of biological age, compared with healthy subjects, but it is unclear whether this is of prognostic significance. We therefore sought to determine whether LTL is associated with outcomes in patients with heart failure.MethodsWe measured LTL in patients with heart failure from the BIOSTAT-CHF Index (n=2260) and BIOSTAT-CHF Tayside (n=1413) cohorts. Cox proportional hazards analyses were performed individually in each cohort and the estimates combined using meta-analysis. Our co-primary endpoints were all-cause mortality and heart failure hospitalisation.ResultsIn age-adjusted and sex-adjusted analyses, shorter LTL was associated with higher all-cause mortality in both cohorts individually and when combined (meta-analysis HR (per SD decrease in LTL)=1.16 (95% CI 1.08 to 1.24); p=2.66×10−5), an effect equivalent to that of being four years older. The association remained significant after adjustment for the BIOSTAT-CHF clinical risk score to account for known prognostic factors (HR=1.12 (95% CI 1.05 to 1.20); p=1.04×10−3). Shorter LTL was associated with both cardiovascular (HR=1.09 (95% CI 1.00 to 1.19); p=0.047) and non-cardiovascular deaths (HR=1.18 (95% CI 1.05 to 1.32); p=4.80×10−3). There was no association between LTL and heart failure hospitalisation (HR=0.99 (95% CI 0.92 to 1.07); p=0.855).ConclusionIn patients with heart failure, shorter mean LTL is independently associated with all-cause mortality.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd and British Cardiovascular Society</pub><pmid>33789973</pmid><doi>10.1136/heartjnl-2020-318654</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-4732-7572</orcidid><orcidid>https://orcid.org/0000-0002-1471-7016</orcidid><orcidid>https://orcid.org/0000-0002-5417-4415</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Age Beta blockers biomarkers Body mass index Cell division Chronic Disease Cohort Studies Diuretics Ejection fraction genetics Heart failure Heart Failure - diagnosis Heart Failure - genetics Heart failure and cardiomyopathies Hospitalization Humans Ischemia Laboratories Leukocytes Medical prognosis Mortality Patients Peptides Regression analysis Risk Factors Telomerase Telomere - genetics Variables |
| title | Telomere length is independently associated with all-cause mortality in chronic heart failure |
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