Visceral Adipose Tissue and Non-alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes
Aim To explore the association of visceral adipose tissue (VAT) area and non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM). Methods This was a cross-sectional study comprising 100 patients with T2DM and 100 non-T2DM individuals, matched for age, sex, and body...
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| Veröffentlicht in: | Digestive diseases and sciences 2022-04, Vol.67 (4), p.1389-1398 |
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| creator | Nobarani, Sohrab Alaei-Shahmiri, Fariba Aghili, Rokhsareh Malek, Mojtaba Poustchi, Hossein Lahouti, Maryam Khamseh, Mohammad E. |
| description | Aim
To explore the association of visceral adipose tissue (VAT) area and non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM).
Methods
This was a cross-sectional study comprising 100 patients with T2DM and 100 non-T2DM individuals, matched for age, sex, and body mass index (BMI). Transient elastography was used to assess hepatic steatosis and liver stiffness measurements (LSM). Controlled attenuation parameter (CAP) was used to quantify hepatic steatosis. To distinguish grades of hepatic steatosis, cutoff values were as follows:
S
1 ≥ 302,
S
2 ≥ 331, and
S
3 ≥ 337 dB/m. Moreover, VAT area was measured by dual-energy X-ray absorptiometry in accordance with validated protocols.
Results
CAP score was significantly higher in participants with T2DM (294.61 ± 3.82 vs. 269.86 ± 3.86 dB/ m;
P
S
1: 302 dB/m), while this figure was 26% in non-T2DM group (
P
|
| doi_str_mv | 10.1007/s10620-021-06953-z |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2507725477</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A706398807</galeid><sourcerecordid>A706398807</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-bbf416095fd3704d68a14b1b99f74c933d916c5bd38a1982e61b9e2a5ea913c63</originalsourceid><addsrcrecordid>eNp9kU9vFCEYxonR2LX6BTwYEi9epvJvYDhuqlWTTeth9ShhmHdamllYgdFsP72sW9toTMMBwvN7nrzwIPSSkhNKiHqbKZGMNITRhkjd8ubmEVrQVvGGtbJ7jBaEynqmVB6hZzlfE0K0ovIpOuJcdR3R7QJ9--qzg2QnvBz8NmbAa5_zDNiGAZ_H0NjJxas4eYfPbCk7vPI_IOF3PoOtsA_4sy0eQsn4py9XeL3bAmZVtz0UyM_Rk9FOGV7c7sfoy9n79enHZnXx4dPpctU4IVhp-n4UVNaBxoErIgbZWSp62ms9KuE054Om0rX9wKugOwayasBsC1ZT7iQ_Rm8OudsUv8-Qi9ns3zVNNkCcs2EtUYq1QqmKvv4HvY5zCnU6w6SQXAvK2D11aScwPoyxJOv2oWapSKXq_-2zTv5D1TXAxrsYYPT1_i8DOxhcijknGM02-Y1NO0OJ2ZdqDqWaWqr5Xaq5qaZXtxPP_QaGO8ufFivAD0CuUriEdP-kB2J_AdbBqh4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2646394122</pqid></control><display><type>article</type><title>Visceral Adipose Tissue and Non-alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Nobarani, Sohrab ; Alaei-Shahmiri, Fariba ; Aghili, Rokhsareh ; Malek, Mojtaba ; Poustchi, Hossein ; Lahouti, Maryam ; Khamseh, Mohammad E.</creator><creatorcontrib>Nobarani, Sohrab ; Alaei-Shahmiri, Fariba ; Aghili, Rokhsareh ; Malek, Mojtaba ; Poustchi, Hossein ; Lahouti, Maryam ; Khamseh, Mohammad E.</creatorcontrib><description>Aim
To explore the association of visceral adipose tissue (VAT) area and non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM).
Methods
This was a cross-sectional study comprising 100 patients with T2DM and 100 non-T2DM individuals, matched for age, sex, and body mass index (BMI). Transient elastography was used to assess hepatic steatosis and liver stiffness measurements (LSM). Controlled attenuation parameter (CAP) was used to quantify hepatic steatosis. To distinguish grades of hepatic steatosis, cutoff values were as follows:
S
1 ≥ 302,
S
2 ≥ 331, and
S
3 ≥ 337 dB/m. Moreover, VAT area was measured by dual-energy X-ray absorptiometry in accordance with validated protocols.
Results
CAP score was significantly higher in participants with T2DM (294.61 ± 3.82 vs. 269.86 ± 3.86 dB/ m;
P
< 0.001). Furthermore, 42% of participants with T2DM had hepatic steatosis (
S
>
S
1: 302 dB/m), while this figure was 26% in non-T2DM group (
P
< 0.003). The mean liver stiffness measuremen
t
was also significantly higher in patients with T2DM (5.53 vs. 4.79 kPa;
P
< 0.001). VAT area was greater in patients with T2DM compared to non-T2DM individuals: 163.79 ± 47.98 cm
2
versus 147.49 ± 39.09 cm
2
,
P
= 0.009. However, total and truncal fat mass were not different between the two groups. Age, BMI, waist circumference, ALT, CAP, and LSM were significantly associated with VAT area. BMI and VAT area were the important determinants of steatosis in both groups of participants with and without T2DM. Moreover, the VAT area was associated with the severity of hepatic steatosis and liver stiffness, independent of anthropometric measures of obesity.
Conclusion
VAT area is a major determinant of the severity of hepatic steatosis and liver stiffness in patient with T2DM.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/s10620-021-06953-z</identifier><identifier>PMID: 33788095</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adipose tissues ; Biochemistry ; Body fat ; Body mass index ; Care and treatment ; Cross-Sectional Studies ; Diabetes ; Diabetes Mellitus, Type 2 - complications ; Elasticity Imaging Techniques - methods ; Fatty liver ; Gastroenterology ; Hepatology ; Humans ; Intra-Abdominal Fat - diagnostic imaging ; Liver - diagnostic imaging ; Liver diseases ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Non-alcoholic Fatty Liver Disease - complications ; Non-alcoholic Fatty Liver Disease - diagnostic imaging ; Oncology ; Original Article ; Transplant Surgery ; Type 2 diabetes</subject><ispartof>Digestive diseases and sciences, 2022-04, Vol.67 (4), p.1389-1398</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><rights>COPYRIGHT 2022 Springer</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-bbf416095fd3704d68a14b1b99f74c933d916c5bd38a1982e61b9e2a5ea913c63</citedby><cites>FETCH-LOGICAL-c442t-bbf416095fd3704d68a14b1b99f74c933d916c5bd38a1982e61b9e2a5ea913c63</cites><orcidid>0000-0003-4313-8440</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10620-021-06953-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10620-021-06953-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33788095$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nobarani, Sohrab</creatorcontrib><creatorcontrib>Alaei-Shahmiri, Fariba</creatorcontrib><creatorcontrib>Aghili, Rokhsareh</creatorcontrib><creatorcontrib>Malek, Mojtaba</creatorcontrib><creatorcontrib>Poustchi, Hossein</creatorcontrib><creatorcontrib>Lahouti, Maryam</creatorcontrib><creatorcontrib>Khamseh, Mohammad E.</creatorcontrib><title>Visceral Adipose Tissue and Non-alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><addtitle>Dig Dis Sci</addtitle><description>Aim
To explore the association of visceral adipose tissue (VAT) area and non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM).
Methods
This was a cross-sectional study comprising 100 patients with T2DM and 100 non-T2DM individuals, matched for age, sex, and body mass index (BMI). Transient elastography was used to assess hepatic steatosis and liver stiffness measurements (LSM). Controlled attenuation parameter (CAP) was used to quantify hepatic steatosis. To distinguish grades of hepatic steatosis, cutoff values were as follows:
S
1 ≥ 302,
S
2 ≥ 331, and
S
3 ≥ 337 dB/m. Moreover, VAT area was measured by dual-energy X-ray absorptiometry in accordance with validated protocols.
Results
CAP score was significantly higher in participants with T2DM (294.61 ± 3.82 vs. 269.86 ± 3.86 dB/ m;
P
< 0.001). Furthermore, 42% of participants with T2DM had hepatic steatosis (
S
>
S
1: 302 dB/m), while this figure was 26% in non-T2DM group (
P
< 0.003). The mean liver stiffness measuremen
t
was also significantly higher in patients with T2DM (5.53 vs. 4.79 kPa;
P
< 0.001). VAT area was greater in patients with T2DM compared to non-T2DM individuals: 163.79 ± 47.98 cm
2
versus 147.49 ± 39.09 cm
2
,
P
= 0.009. However, total and truncal fat mass were not different between the two groups. Age, BMI, waist circumference, ALT, CAP, and LSM were significantly associated with VAT area. BMI and VAT area were the important determinants of steatosis in both groups of participants with and without T2DM. Moreover, the VAT area was associated with the severity of hepatic steatosis and liver stiffness, independent of anthropometric measures of obesity.
Conclusion
VAT area is a major determinant of the severity of hepatic steatosis and liver stiffness in patient with T2DM.</description><subject>Adipose tissues</subject><subject>Biochemistry</subject><subject>Body fat</subject><subject>Body mass index</subject><subject>Care and treatment</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Elasticity Imaging Techniques - methods</subject><subject>Fatty liver</subject><subject>Gastroenterology</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Intra-Abdominal Fat - diagnostic imaging</subject><subject>Liver - diagnostic imaging</subject><subject>Liver diseases</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Non-alcoholic Fatty Liver Disease - complications</subject><subject>Non-alcoholic Fatty Liver Disease - diagnostic imaging</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Transplant Surgery</subject><subject>Type 2 diabetes</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kU9vFCEYxonR2LX6BTwYEi9epvJvYDhuqlWTTeth9ShhmHdamllYgdFsP72sW9toTMMBwvN7nrzwIPSSkhNKiHqbKZGMNITRhkjd8ubmEVrQVvGGtbJ7jBaEynqmVB6hZzlfE0K0ovIpOuJcdR3R7QJ9--qzg2QnvBz8NmbAa5_zDNiGAZ_H0NjJxas4eYfPbCk7vPI_IOF3PoOtsA_4sy0eQsn4py9XeL3bAmZVtz0UyM_Rk9FOGV7c7sfoy9n79enHZnXx4dPpctU4IVhp-n4UVNaBxoErIgbZWSp62ms9KuE054Om0rX9wKugOwayasBsC1ZT7iQ_Rm8OudsUv8-Qi9ns3zVNNkCcs2EtUYq1QqmKvv4HvY5zCnU6w6SQXAvK2D11aScwPoyxJOv2oWapSKXq_-2zTv5D1TXAxrsYYPT1_i8DOxhcijknGM02-Y1NO0OJ2ZdqDqWaWqr5Xaq5qaZXtxPP_QaGO8ufFivAD0CuUriEdP-kB2J_AdbBqh4</recordid><startdate>20220401</startdate><enddate>20220401</enddate><creator>Nobarani, Sohrab</creator><creator>Alaei-Shahmiri, Fariba</creator><creator>Aghili, Rokhsareh</creator><creator>Malek, Mojtaba</creator><creator>Poustchi, Hossein</creator><creator>Lahouti, Maryam</creator><creator>Khamseh, Mohammad E.</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4313-8440</orcidid></search><sort><creationdate>20220401</creationdate><title>Visceral Adipose Tissue and Non-alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes</title><author>Nobarani, Sohrab ; Alaei-Shahmiri, Fariba ; Aghili, Rokhsareh ; Malek, Mojtaba ; Poustchi, Hossein ; Lahouti, Maryam ; Khamseh, Mohammad E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-bbf416095fd3704d68a14b1b99f74c933d916c5bd38a1982e61b9e2a5ea913c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adipose tissues</topic><topic>Biochemistry</topic><topic>Body fat</topic><topic>Body mass index</topic><topic>Care and treatment</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Elasticity Imaging Techniques - methods</topic><topic>Fatty liver</topic><topic>Gastroenterology</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Intra-Abdominal Fat - diagnostic imaging</topic><topic>Liver - diagnostic imaging</topic><topic>Liver diseases</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Non-alcoholic Fatty Liver Disease - complications</topic><topic>Non-alcoholic Fatty Liver Disease - diagnostic imaging</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Transplant Surgery</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nobarani, Sohrab</creatorcontrib><creatorcontrib>Alaei-Shahmiri, Fariba</creatorcontrib><creatorcontrib>Aghili, Rokhsareh</creatorcontrib><creatorcontrib>Malek, Mojtaba</creatorcontrib><creatorcontrib>Poustchi, Hossein</creatorcontrib><creatorcontrib>Lahouti, Maryam</creatorcontrib><creatorcontrib>Khamseh, Mohammad E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nobarani, Sohrab</au><au>Alaei-Shahmiri, Fariba</au><au>Aghili, Rokhsareh</au><au>Malek, Mojtaba</au><au>Poustchi, Hossein</au><au>Lahouti, Maryam</au><au>Khamseh, Mohammad E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Visceral Adipose Tissue and Non-alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes</atitle><jtitle>Digestive diseases and sciences</jtitle><stitle>Dig Dis Sci</stitle><addtitle>Dig Dis Sci</addtitle><date>2022-04-01</date><risdate>2022</risdate><volume>67</volume><issue>4</issue><spage>1389</spage><epage>1398</epage><pages>1389-1398</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><abstract>Aim
To explore the association of visceral adipose tissue (VAT) area and non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM).
Methods
This was a cross-sectional study comprising 100 patients with T2DM and 100 non-T2DM individuals, matched for age, sex, and body mass index (BMI). Transient elastography was used to assess hepatic steatosis and liver stiffness measurements (LSM). Controlled attenuation parameter (CAP) was used to quantify hepatic steatosis. To distinguish grades of hepatic steatosis, cutoff values were as follows:
S
1 ≥ 302,
S
2 ≥ 331, and
S
3 ≥ 337 dB/m. Moreover, VAT area was measured by dual-energy X-ray absorptiometry in accordance with validated protocols.
Results
CAP score was significantly higher in participants with T2DM (294.61 ± 3.82 vs. 269.86 ± 3.86 dB/ m;
P
< 0.001). Furthermore, 42% of participants with T2DM had hepatic steatosis (
S
>
S
1: 302 dB/m), while this figure was 26% in non-T2DM group (
P
< 0.003). The mean liver stiffness measuremen
t
was also significantly higher in patients with T2DM (5.53 vs. 4.79 kPa;
P
< 0.001). VAT area was greater in patients with T2DM compared to non-T2DM individuals: 163.79 ± 47.98 cm
2
versus 147.49 ± 39.09 cm
2
,
P
= 0.009. However, total and truncal fat mass were not different between the two groups. Age, BMI, waist circumference, ALT, CAP, and LSM were significantly associated with VAT area. BMI and VAT area were the important determinants of steatosis in both groups of participants with and without T2DM. Moreover, the VAT area was associated with the severity of hepatic steatosis and liver stiffness, independent of anthropometric measures of obesity.
Conclusion
VAT area is a major determinant of the severity of hepatic steatosis and liver stiffness in patient with T2DM.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>33788095</pmid><doi>10.1007/s10620-021-06953-z</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-4313-8440</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0163-2116 |
| ispartof | Digestive diseases and sciences, 2022-04, Vol.67 (4), p.1389-1398 |
| issn | 0163-2116 1573-2568 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2507725477 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adipose tissues Biochemistry Body fat Body mass index Care and treatment Cross-Sectional Studies Diabetes Diabetes Mellitus, Type 2 - complications Elasticity Imaging Techniques - methods Fatty liver Gastroenterology Hepatology Humans Intra-Abdominal Fat - diagnostic imaging Liver - diagnostic imaging Liver diseases Medical research Medicine Medicine & Public Health Medicine, Experimental Non-alcoholic Fatty Liver Disease - complications Non-alcoholic Fatty Liver Disease - diagnostic imaging Oncology Original Article Transplant Surgery Type 2 diabetes |
| title | Visceral Adipose Tissue and Non-alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes |
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