Post-transcriptional regulation of MMP2 mRNA by its interaction with miR-20a and Nucleolin in breast cancer cell lines

Matrix-metalloproteinase-2 (MMP2) is a foremost MMP, governing invasion of breast cancer cells during metastasis. miR-20a was reported to induce mesenchymal to epithelial transition in MDA-MB-231 cells and its endogenous expression varies directly with invasiveness of breast cancer cells. The invers...

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Veröffentlicht in:	Molecular biology reports 2021-03, Vol.48 (3), p.2315-2324
Hauptverfasser:	Das, Sayantani, De, Soumasree, Sengupta, Sumita
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated regions 3' Untranslated Regions - genetics Animal Anatomy Animal Biochemistry Argonaute 2 protein Base Sequence Binding sites Binding Sites - genetics Biomedical and Life Sciences Breast cancer Breast Neoplasms - enzymology Breast Neoplasms - genetics Cell Line, Tumor Computer Simulation Down-regulation Down-Regulation - genetics Enzymatic activity Female Gelatinase A Gene Expression Regulation, Neoplastic Gene regulation Histology Humans Immunoprecipitation Invasiveness Life Sciences Matrix metalloproteinase Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 2 - metabolism Mesenchyme Metalloproteinase Metastases MicroRNAs - genetics MicroRNAs - metabolism miRNA Morphology mRNA stability Nucleolin Original Article Overexpression Phosphoproteins - metabolism Post-transcription Protein Binding Proteins RNA Stability - genetics RNA, Messenger - genetics RNA, Messenger - metabolism RNA-Binding Proteins - metabolism Tumor cell lines
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