Isolation of New Colibactin Metabolites from Wild-Type Escherichia coli and In Situ Trapping of a Mature Colibactin Derivative

Colibactin is a polyketide-nonribosomal peptide hybrid secondary metabolite that can form interstrand cross-links in double-stranded DNA. Colibactin-producing Escherichia coli has also been linked to colorectal oncogenesis. Thus, there is a strong interest in understanding the role colibactin may pl...

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Veröffentlicht in:	Journal of the American Chemical Society 2021-04, Vol.143 (14), p.5526-5533
Hauptverfasser:	Zhou, Tao, Hirayama, Yuichiro, Tsunematsu, Yuta, Suzuki, Nanami, Tanaka, Seiji, Uchiyama, Nahoko, Goda, Yukihiro, Yoshikawa, Yuko, Iwashita, Yuji, Sato, Michio, Miyoshi, Noriyuki, Mutoh, Michihiro, Ishikawa, Hideki, Sugimura, Haruhiko, Wakabayashi, Keiji, Watanabe, Kenji
Format:	Artikel
Sprache:	eng
Schlagworte:	Biopolymers - chemistry Biopolymers - metabolism Escherichia coli - chemistry Escherichia coli - metabolism Peptides - chemistry Peptides - metabolism Polyketides - chemistry Polyketides - metabolism
Online-Zugang:	Volltext
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