Phenotypic heterogeneity, stability and plasticity in tumor‐promoting carcinoma‐associated fibroblasts

Reciprocal interactions between cancer cells and stromal cells in the tumor microenvironment (TME) are essential for full‐blown tumor development. Carcinoma‐associated fibroblasts (CAFs) are a key component of the TME together with a wide variety of stromal cell types including vascular, inflammator...

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Veröffentlicht in:	The FEBS journal 2022-05, Vol.289 (9), p.2429-2447
Hauptverfasser:	Mezawa, Yoshihiro, Orimo, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	activated fibroblastic phenotypes Cancer Cancer-Associated Fibroblasts - metabolism Carcinoma - metabolism carcinoma‐associated fibroblasts Extracellular matrix Fibroblasts Fibroblasts - metabolism Heterogeneity Humans Immune checkpoint inhibitors Immune system Inflammation Metastases Molecular modelling Phenotype Phenotypes Phenotypic plasticity Plastic properties Plasticity Populations Stability Stromal cells Tumor microenvironment Tumor Microenvironment - genetics Tumors
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