Effects of beclomethasone and aminophylline combined with enteral nutrition in chronic obstructive pulmonary disease on nutritional status and immune function in elders
Background and Objectives: To investigate the efficacy of beclomethasone and aminophylline combined with enteral nutrition in the treatment of elderly patients with chronic obstructive pulmonary disease (COPD) and the associated effects of these drugs on patient nutritional status and immune functio...
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| Veröffentlicht in: | Asia Pacific Journal of Clinical Nutrition 2021-03, Vol.30 (1), p.60-66 |
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| container_title | Asia Pacific Journal of Clinical Nutrition |
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| creator | Peng, Can Xiao, Dongjie Chen, Haiyan Rao, Lijie Xiao, Haiyan Li, Huahua |
| description | Background and Objectives: To investigate the efficacy of beclomethasone and aminophylline combined with enteral nutrition in the treatment of elderly patients with chronic obstructive pulmonary disease (COPD) and the associated effects of these drugs on patient nutritional status and immune function. Methods and Study Design: In total, 115 elderly patients with COPD were included and were randomized into an enteral nutrition (EN) group and a control (CON) group. Aminophylline, in combination with beclomethasone, was administered to the CON group, whereas aminophylline and beclomethasone in combination with EN was administered to the EN group. Results: Patients in the EN group showed significant improvement in partial pressure of carbon dioxide, forced expiratory volume in 1 sec/ expiratory forced vital capacity, and partial pressure of oxygen than those in the CON group. The levels of IgM, IgG, and IgA as well as the number of CD4+/CD8+ and CD4+/CD3+ T cells were higher in the EN group than those in the CON group (p＜0.05); the EN group also exhibited higher levels of inflammatory cytokines, such as tumor necrosis factor-α and interleukin (IL)-1β (p＜0.05), and lower levels of IL-6 than the CON group. In addition, patients in the EN group showed a significant increase in serum total protein, albumin, and transferrin levels than those in the CON group (p＜0.05). Conclusions: Elderly patients with COPD showed a marked response to a regimen of beclomethasone, aminophylline, and EN, which significantly improved their immune function and nutritional status. |
| doi_str_mv | 10.6133/apjcn.202103_30(1).0008 |
| format | Article |
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Methods and Study Design: In total, 115 elderly patients with COPD were included and were randomized into an enteral nutrition (EN) group and a control (CON) group. Aminophylline, in combination with beclomethasone, was administered to the CON group, whereas aminophylline and beclomethasone in combination with EN was administered to the EN group. Results: Patients in the EN group showed significant improvement in partial pressure of carbon dioxide, forced expiratory volume in 1 sec/ expiratory forced vital capacity, and partial pressure of oxygen than those in the CON group. The levels of IgM, IgG, and IgA as well as the number of CD4+/CD8+ and CD4+/CD3+ T cells were higher in the EN group than those in the CON group (p＜0.05); the EN group also exhibited higher levels of inflammatory cytokines, such as tumor necrosis factor-α and interleukin (IL)-1β (p＜0.05), and lower levels of IL-6 than the CON group. In addition, patients in the EN group showed a significant increase in serum total protein, albumin, and transferrin levels than those in the CON group (p＜0.05). Conclusions: Elderly patients with COPD showed a marked response to a regimen of beclomethasone, aminophylline, and EN, which significantly improved their immune function and nutritional status.</description><identifier>ISSN: 0964-7058</identifier><identifier>EISSN: 1440-6047</identifier><identifier>DOI: 10.6133/apjcn.202103_30(1).0008</identifier><identifier>PMID: 33787041</identifier><language>eng</language><publisher>Australia: HEC Press</publisher><subject>Age ; Asthma ; Carbon dioxide ; Chronic obstructive pulmonary disease ; Cytokines ; Enteral nutrition ; Expected values ; Hospitals ; Nutrition research ; Nutritional status ; Nutritionists ; Patients ; Tumor necrosis factor-TNF</subject><ispartof>Asia Pacific Journal of Clinical Nutrition, 2021-03, Vol.30 (1), p.60-66</ispartof><rights>Copyright HEC Press Mar 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33787041$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peng, Can</creatorcontrib><creatorcontrib>Xiao, Dongjie</creatorcontrib><creatorcontrib>Chen, Haiyan</creatorcontrib><creatorcontrib>Rao, Lijie</creatorcontrib><creatorcontrib>Xiao, Haiyan</creatorcontrib><creatorcontrib>Li, Huahua</creatorcontrib><title>Effects of beclomethasone and aminophylline combined with enteral nutrition in chronic obstructive pulmonary disease on nutritional status and immune function in elders</title><title>Asia Pacific Journal of Clinical Nutrition</title><addtitle>Asia Pac J Clin Nutr</addtitle><description>Background and Objectives: To investigate the efficacy of beclomethasone and aminophylline combined with enteral nutrition in the treatment of elderly patients with chronic obstructive pulmonary disease (COPD) and the associated effects of these drugs on patient nutritional status and immune function. Methods and Study Design: In total, 115 elderly patients with COPD were included and were randomized into an enteral nutrition (EN) group and a control (CON) group. Aminophylline, in combination with beclomethasone, was administered to the CON group, whereas aminophylline and beclomethasone in combination with EN was administered to the EN group. Results: Patients in the EN group showed significant improvement in partial pressure of carbon dioxide, forced expiratory volume in 1 sec/ expiratory forced vital capacity, and partial pressure of oxygen than those in the CON group. The levels of IgM, IgG, and IgA as well as the number of CD4+/CD8+ and CD4+/CD3+ T cells were higher in the EN group than those in the CON group (p＜0.05); the EN group also exhibited higher levels of inflammatory cytokines, such as tumor necrosis factor-α and interleukin (IL)-1β (p＜0.05), and lower levels of IL-6 than the CON group. In addition, patients in the EN group showed a significant increase in serum total protein, albumin, and transferrin levels than those in the CON group (p＜0.05). Conclusions: Elderly patients with COPD showed a marked response to a regimen of beclomethasone, aminophylline, and EN, which significantly improved their immune function and nutritional status.</description><subject>Age</subject><subject>Asthma</subject><subject>Carbon dioxide</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Cytokines</subject><subject>Enteral nutrition</subject><subject>Expected values</subject><subject>Hospitals</subject><subject>Nutrition research</subject><subject>Nutritional status</subject><subject>Nutritionists</subject><subject>Patients</subject><subject>Tumor necrosis factor-TNF</subject><issn>0964-7058</issn><issn>1440-6047</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdkc1u1DAUhS0EotPCK4AlNmWR4fpnnGSJqpYiVWID68ixbzQeJXbwD6hvxGPiaacgWB3dq8_nyucQ8pbBVjEhPuj1YPyWA2cgBgGX7P0WALpnZMOkhEaBbJ-TDfRKNi3sujNyntKhEkLC7iU5E6LtWpBsQ35dTxOanGiY6IhmDgvmvU7BI9XeUr04H9b9_Ty7ujFhGata-tPlPUWfMeqZ-pKjyy546jw1-xi8MzSMKcdisvuBdC3zEryO99S6hDohreyfV9UhZZ1LejjolqXUS1Px5skSZ4sxvSIvJj0nfH3SC_Lt5vrr1W1z9-XT56uPd40WwHMzmra1eoSxnwRXDHotrQANOE4dUxaNVVpNnRFW7UYuax5Wtr3tkU9WKsXFBbl89F1j-F4w5WFxyeA8a4-hpIHvoFVKSdFV9N1_6CGUWD90pDhnPe96Vak3J6qMC9phjW6pWQxPHVTg5hHQ7pjIX5Njfcf2hlPPDyKhrT2yfwcFg1LiN34-ouk</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Peng, Can</creator><creator>Xiao, Dongjie</creator><creator>Chen, Haiyan</creator><creator>Rao, Lijie</creator><creator>Xiao, Haiyan</creator><creator>Li, Huahua</creator><general>HEC Press</general><scope>188</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BVBZV</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20210301</creationdate><title>Effects of beclomethasone and aminophylline combined with enteral nutrition in chronic obstructive pulmonary disease on nutritional status and immune function in elders</title><author>Peng, Can ; Xiao, Dongjie ; Chen, Haiyan ; Rao, Lijie ; Xiao, Haiyan ; Li, Huahua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a302t-bc77dab0b9f326109a4d30a0ebf816decd6a6f8c3d65b24340d479d9e2fd46623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Age</topic><topic>Asthma</topic><topic>Carbon dioxide</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Cytokines</topic><topic>Enteral nutrition</topic><topic>Expected values</topic><topic>Hospitals</topic><topic>Nutrition research</topic><topic>Nutritional status</topic><topic>Nutritionists</topic><topic>Patients</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peng, Can</creatorcontrib><creatorcontrib>Xiao, Dongjie</creatorcontrib><creatorcontrib>Chen, Haiyan</creatorcontrib><creatorcontrib>Rao, Lijie</creatorcontrib><creatorcontrib>Xiao, Haiyan</creatorcontrib><creatorcontrib>Li, Huahua</creatorcontrib><collection>Airiti Library</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>East & South Asia Database</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Asia Pacific Journal of Clinical Nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peng, Can</au><au>Xiao, Dongjie</au><au>Chen, Haiyan</au><au>Rao, Lijie</au><au>Xiao, Haiyan</au><au>Li, Huahua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of beclomethasone and aminophylline combined with enteral nutrition in chronic obstructive pulmonary disease on nutritional status and immune function in elders</atitle><jtitle>Asia Pacific Journal of Clinical Nutrition</jtitle><addtitle>Asia Pac J Clin Nutr</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>30</volume><issue>1</issue><spage>60</spage><epage>66</epage><pages>60-66</pages><issn>0964-7058</issn><eissn>1440-6047</eissn><abstract>Background and Objectives: To investigate the efficacy of beclomethasone and aminophylline combined with enteral nutrition in the treatment of elderly patients with chronic obstructive pulmonary disease (COPD) and the associated effects of these drugs on patient nutritional status and immune function. Methods and Study Design: In total, 115 elderly patients with COPD were included and were randomized into an enteral nutrition (EN) group and a control (CON) group. Aminophylline, in combination with beclomethasone, was administered to the CON group, whereas aminophylline and beclomethasone in combination with EN was administered to the EN group. Results: Patients in the EN group showed significant improvement in partial pressure of carbon dioxide, forced expiratory volume in 1 sec/ expiratory forced vital capacity, and partial pressure of oxygen than those in the CON group. The levels of IgM, IgG, and IgA as well as the number of CD4+/CD8+ and CD4+/CD3+ T cells were higher in the EN group than those in the CON group (p＜0.05); the EN group also exhibited higher levels of inflammatory cytokines, such as tumor necrosis factor-α and interleukin (IL)-1β (p＜0.05), and lower levels of IL-6 than the CON group. In addition, patients in the EN group showed a significant increase in serum total protein, albumin, and transferrin levels than those in the CON group (p＜0.05). Conclusions: Elderly patients with COPD showed a marked response to a regimen of beclomethasone, aminophylline, and EN, which significantly improved their immune function and nutritional status.</abstract><cop>Australia</cop><pub>HEC Press</pub><pmid>33787041</pmid><doi>10.6133/apjcn.202103_30(1).0008</doi><tpages>7</tpages></addata></record> |
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| subjects | Age Asthma Carbon dioxide Chronic obstructive pulmonary disease Cytokines Enteral nutrition Expected values Hospitals Nutrition research Nutritional status Nutritionists Patients Tumor necrosis factor-TNF |
| title | Effects of beclomethasone and aminophylline combined with enteral nutrition in chronic obstructive pulmonary disease on nutritional status and immune function in elders |
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