Meibum lipid composition in type 2 diabetics with dry eye
The purpose of this investigation was to analyze and compare the composition of meibum between type 2 diabetics with dry eye disease (DED) and control subjects to better reveal the pathologic mechanisms of the meibomian gland degeneration (MGD) and DED in type 2 diabetes mellitus (T2DM). 90 subjects...
Gespeichert in:
| Veröffentlicht in: | Experimental eye research 2021-05, Vol.206, p.108522-108522, Article 108522 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 108522 |
|---|---|
| container_issue | |
| container_start_page | 108522 |
| container_title | Experimental eye research |
| container_volume | 206 |
| creator | Yang, Qin Li, Bing Sheng, Minjie |
| description | The purpose of this investigation was to analyze and compare the composition of meibum between type 2 diabetics with dry eye disease (DED) and control subjects to better reveal the pathologic mechanisms of the meibomian gland degeneration (MGD) and DED in type 2 diabetes mellitus (T2DM).
90 subjects were divided into the following 4 groups: DM-DED group: T2DM patients with DED (n = 30); DM control group: DM patients without DED (n = 18); DED group: DED patients without DM (n = 26); naive control group: normal subjects (n = 16). The lipid composition of meibum samples collected from these subjects was analyzed by high-pressure liquid chromatography–mass spectrometry (HPLC-MS) system. The content of lipid features from 12 major lipid classes was compared among the 4 groups.
A significantly lower level of triacylglycerols (TG) and wax esters (WE) was found between DM-DED patients and normal controls (P |
| doi_str_mv | 10.1016/j.exer.2021.108522 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2507153297</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0014483521000877</els_id><sourcerecordid>2507153297</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-8b1b2ab998cdb7b23c533aab29993dbeb907b3e3048dffb740f8d0c8a75335583</originalsourceid><addsrcrecordid>eNp9kEtLxDAUhYMozjj6B1xIlm465tFMEnAjgy8YcaPr0CS3mKGd1qZV--_NUHXp6sLhOwfuh9A5JUtK6Opqu4Qv6JaMMJoCJRg7QHNK9CojhMhDNCeE5lmuuJihkxi3KeW5zI_RjHOpqBT5HOknCHaocRXa4LFr6raJoQ_NDocd7scWMMM-FBb64CL-DP0b9t2IYYRTdFQWVYSzn7tAr3e3L-uHbPN8_7i-2WSOi1WfKUstK6zWynkrLeNOcF4UlmmtubdgNZGWAye58mVpZU5K5YlThUycEIov0OW023bN-wCxN3WIDqqq2EEzRMMEkVRwpmVC2YS6romxg9K0XaiLbjSUmL0yszV7ZWavzEzKUuniZ3-wNfi_yq-jBFxPAKQvP0KqRxdg58CHDlxvfBP-2_8Gx1x7zQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2507153297</pqid></control><display><type>article</type><title>Meibum lipid composition in type 2 diabetics with dry eye</title><source>Elsevier ScienceDirect Journals</source><creator>Yang, Qin ; Li, Bing ; Sheng, Minjie</creator><creatorcontrib>Yang, Qin ; Li, Bing ; Sheng, Minjie</creatorcontrib><description>The purpose of this investigation was to analyze and compare the composition of meibum between type 2 diabetics with dry eye disease (DED) and control subjects to better reveal the pathologic mechanisms of the meibomian gland degeneration (MGD) and DED in type 2 diabetes mellitus (T2DM).
90 subjects were divided into the following 4 groups: DM-DED group: T2DM patients with DED (n = 30); DM control group: DM patients without DED (n = 18); DED group: DED patients without DM (n = 26); naive control group: normal subjects (n = 16). The lipid composition of meibum samples collected from these subjects was analyzed by high-pressure liquid chromatography–mass spectrometry (HPLC-MS) system. The content of lipid features from 12 major lipid classes was compared among the 4 groups.
A significantly lower level of triacylglycerols (TG) and wax esters (WE) was found between DM-DED patients and normal controls (P < 0.01), whereas the level of Cholesteryl Ester (CE) in DM-DED patients increased compared with DED patients (P < 0.05). The level of (O-acyl)-omega-hydroxy fatty acids (OAHFA) in DM-DED patients was significantly lower than that in normal controls (P < 0.01). An opposite higher level of phospholipids (PLs) was observed in DM-DED patients than that in normal controls (P < 0.01).
T2DM could influence the expression of meibum lipids to further aggravate DED and MGD. Lower expression of TG,WE and OAHFA, higher expression of CE and PLs were discovered in meibum lipids of T2DM-DED.
•The incidence of dry eye in diabetes was much higher with diabetes as a risk factor.•The abnormal expression of meibum lipids could break homeostasis of the tear film.•The meibum lipids composition was largely different in dry eye patients with type 2 diabetes from nondiabetic ones.•Type 2 diabetes mellitus could influence the expression of meibum lipids to further aggravate dry eye.</description><identifier>ISSN: 0014-4835</identifier><identifier>EISSN: 1096-0007</identifier><identifier>DOI: 10.1016/j.exer.2021.108522</identifier><identifier>PMID: 33781754</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Diabetes mellitus ; Dry eye disease ; Lipids ; Mass spectrometry ; Meibum</subject><ispartof>Experimental eye research, 2021-05, Vol.206, p.108522-108522, Article 108522</ispartof><rights>2021</rights><rights>Copyright © 2021. Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-8b1b2ab998cdb7b23c533aab29993dbeb907b3e3048dffb740f8d0c8a75335583</citedby><cites>FETCH-LOGICAL-c356t-8b1b2ab998cdb7b23c533aab29993dbeb907b3e3048dffb740f8d0c8a75335583</cites><orcidid>0000-0003-3176-7055</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0014483521000877$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33781754$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Qin</creatorcontrib><creatorcontrib>Li, Bing</creatorcontrib><creatorcontrib>Sheng, Minjie</creatorcontrib><title>Meibum lipid composition in type 2 diabetics with dry eye</title><title>Experimental eye research</title><addtitle>Exp Eye Res</addtitle><description>The purpose of this investigation was to analyze and compare the composition of meibum between type 2 diabetics with dry eye disease (DED) and control subjects to better reveal the pathologic mechanisms of the meibomian gland degeneration (MGD) and DED in type 2 diabetes mellitus (T2DM).
90 subjects were divided into the following 4 groups: DM-DED group: T2DM patients with DED (n = 30); DM control group: DM patients without DED (n = 18); DED group: DED patients without DM (n = 26); naive control group: normal subjects (n = 16). The lipid composition of meibum samples collected from these subjects was analyzed by high-pressure liquid chromatography–mass spectrometry (HPLC-MS) system. The content of lipid features from 12 major lipid classes was compared among the 4 groups.
A significantly lower level of triacylglycerols (TG) and wax esters (WE) was found between DM-DED patients and normal controls (P < 0.01), whereas the level of Cholesteryl Ester (CE) in DM-DED patients increased compared with DED patients (P < 0.05). The level of (O-acyl)-omega-hydroxy fatty acids (OAHFA) in DM-DED patients was significantly lower than that in normal controls (P < 0.01). An opposite higher level of phospholipids (PLs) was observed in DM-DED patients than that in normal controls (P < 0.01).
T2DM could influence the expression of meibum lipids to further aggravate DED and MGD. Lower expression of TG,WE and OAHFA, higher expression of CE and PLs were discovered in meibum lipids of T2DM-DED.
•The incidence of dry eye in diabetes was much higher with diabetes as a risk factor.•The abnormal expression of meibum lipids could break homeostasis of the tear film.•The meibum lipids composition was largely different in dry eye patients with type 2 diabetes from nondiabetic ones.•Type 2 diabetes mellitus could influence the expression of meibum lipids to further aggravate dry eye.</description><subject>Diabetes mellitus</subject><subject>Dry eye disease</subject><subject>Lipids</subject><subject>Mass spectrometry</subject><subject>Meibum</subject><issn>0014-4835</issn><issn>1096-0007</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kEtLxDAUhYMozjj6B1xIlm465tFMEnAjgy8YcaPr0CS3mKGd1qZV--_NUHXp6sLhOwfuh9A5JUtK6Opqu4Qv6JaMMJoCJRg7QHNK9CojhMhDNCeE5lmuuJihkxi3KeW5zI_RjHOpqBT5HOknCHaocRXa4LFr6raJoQ_NDocd7scWMMM-FBb64CL-DP0b9t2IYYRTdFQWVYSzn7tAr3e3L-uHbPN8_7i-2WSOi1WfKUstK6zWynkrLeNOcF4UlmmtubdgNZGWAye58mVpZU5K5YlThUycEIov0OW023bN-wCxN3WIDqqq2EEzRMMEkVRwpmVC2YS6romxg9K0XaiLbjSUmL0yszV7ZWavzEzKUuniZ3-wNfi_yq-jBFxPAKQvP0KqRxdg58CHDlxvfBP-2_8Gx1x7zQ</recordid><startdate>202105</startdate><enddate>202105</enddate><creator>Yang, Qin</creator><creator>Li, Bing</creator><creator>Sheng, Minjie</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3176-7055</orcidid></search><sort><creationdate>202105</creationdate><title>Meibum lipid composition in type 2 diabetics with dry eye</title><author>Yang, Qin ; Li, Bing ; Sheng, Minjie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-8b1b2ab998cdb7b23c533aab29993dbeb907b3e3048dffb740f8d0c8a75335583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Diabetes mellitus</topic><topic>Dry eye disease</topic><topic>Lipids</topic><topic>Mass spectrometry</topic><topic>Meibum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Qin</creatorcontrib><creatorcontrib>Li, Bing</creatorcontrib><creatorcontrib>Sheng, Minjie</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental eye research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Qin</au><au>Li, Bing</au><au>Sheng, Minjie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Meibum lipid composition in type 2 diabetics with dry eye</atitle><jtitle>Experimental eye research</jtitle><addtitle>Exp Eye Res</addtitle><date>2021-05</date><risdate>2021</risdate><volume>206</volume><spage>108522</spage><epage>108522</epage><pages>108522-108522</pages><artnum>108522</artnum><issn>0014-4835</issn><eissn>1096-0007</eissn><abstract>The purpose of this investigation was to analyze and compare the composition of meibum between type 2 diabetics with dry eye disease (DED) and control subjects to better reveal the pathologic mechanisms of the meibomian gland degeneration (MGD) and DED in type 2 diabetes mellitus (T2DM).
90 subjects were divided into the following 4 groups: DM-DED group: T2DM patients with DED (n = 30); DM control group: DM patients without DED (n = 18); DED group: DED patients without DM (n = 26); naive control group: normal subjects (n = 16). The lipid composition of meibum samples collected from these subjects was analyzed by high-pressure liquid chromatography–mass spectrometry (HPLC-MS) system. The content of lipid features from 12 major lipid classes was compared among the 4 groups.
A significantly lower level of triacylglycerols (TG) and wax esters (WE) was found between DM-DED patients and normal controls (P < 0.01), whereas the level of Cholesteryl Ester (CE) in DM-DED patients increased compared with DED patients (P < 0.05). The level of (O-acyl)-omega-hydroxy fatty acids (OAHFA) in DM-DED patients was significantly lower than that in normal controls (P < 0.01). An opposite higher level of phospholipids (PLs) was observed in DM-DED patients than that in normal controls (P < 0.01).
T2DM could influence the expression of meibum lipids to further aggravate DED and MGD. Lower expression of TG,WE and OAHFA, higher expression of CE and PLs were discovered in meibum lipids of T2DM-DED.
•The incidence of dry eye in diabetes was much higher with diabetes as a risk factor.•The abnormal expression of meibum lipids could break homeostasis of the tear film.•The meibum lipids composition was largely different in dry eye patients with type 2 diabetes from nondiabetic ones.•Type 2 diabetes mellitus could influence the expression of meibum lipids to further aggravate dry eye.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>33781754</pmid><doi>10.1016/j.exer.2021.108522</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-3176-7055</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-4835 |
| ispartof | Experimental eye research, 2021-05, Vol.206, p.108522-108522, Article 108522 |
| issn | 0014-4835 1096-0007 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2507153297 |
| source | Elsevier ScienceDirect Journals |
| subjects | Diabetes mellitus Dry eye disease Lipids Mass spectrometry Meibum |
| title | Meibum lipid composition in type 2 diabetics with dry eye |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T03%3A02%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Meibum%20lipid%20composition%20in%20type%202%20diabetics%20with%20dry%20eye&rft.jtitle=Experimental%20eye%20research&rft.au=Yang,%20Qin&rft.date=2021-05&rft.volume=206&rft.spage=108522&rft.epage=108522&rft.pages=108522-108522&rft.artnum=108522&rft.issn=0014-4835&rft.eissn=1096-0007&rft_id=info:doi/10.1016/j.exer.2021.108522&rft_dat=%3Cproquest_cross%3E2507153297%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2507153297&rft_id=info:pmid/33781754&rft_els_id=S0014483521000877&rfr_iscdi=true |