Kinetic Resolution of Tertiary Benzyl Alcohols via Palladium/Chiral Norbornene Cooperative Catalysis

Herein we report a highly enantioselective kinetic resolution of tertiary benzyl alcohols via palladium/chiral norbornene cooperative catalysis. With simple aryl iodides as the resolution reagent, a wide range of readily available racemic tertiary benzyl alcohols are applicable to this method. Both...

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Veröffentlicht in:	Angewandte Chemie International Edition 2021-06, Vol.60 (23), p.12824-12828
Hauptverfasser:	Hua, Yu, Liu, Ze‐Shui, Xie, Pei‐Pei, Ding, Bo, Cheng, Hong‐Gang, Hong, Xin, Zhou, Qianghui
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Alcohols Benzyl alcohol Catalysis chiral norbornene Chirality cooperative catalysis Enantiomers Iodides kinetic resolution Palladium Reagents Selectivity tertiary benzyl alcohol transient axial chirality
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