The Roots of Genetic Coding in Aminoacyl-tRNA Synthetase Duality

Codon-dependent translation underlies genetics and phylogenetic inferences, but its origins pose two challenges. Prevailing narratives cannot account for the fact that aminoacyl-tRNA synthetases (aaRSs), which translate the genetic code, must collectively enforce the rules used to assemble themselve...

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Veröffentlicht in:	Annual review of biochemistry 2021-06, Vol.90 (1), p.349-373
Hauptverfasser:	Carter, Charles W, Wills, Peter R
Format:	Artikel
Sprache:	eng
Schlagworte:	amino acid phase transfer equilibria Amino acids Amino Acids - metabolism Amino Acyl-tRNA Synthetases - chemistry Amino Acyl-tRNA Synthetases - genetics Amino Acyl-tRNA Synthetases - metabolism Aminoacyl-tRNA ligase bidirectional coding ancestry Catalysis Differentiation Evolution, Molecular Genetic Code Genetics Genotype Phenotype Phylogeny Protein Biosynthesis Protein Folding protein folding rules Protein structure Protein Structure, Secondary protozymes reflexivity RNA, Transfer - genetics Secondary structure Selection, Genetic Substrates Thermodynamics tRNA Urzymes
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