Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization

Glioblastomas are aggressive primary brain cancers that recur as therapy-resistant tumors. Myeloid cells control glioblastoma malignancy, but their dynamics during disease progression remain poorly understood. Here, we employed single-cell RNA sequencing and CITE-seq to map the glioblastoma immune l...

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Veröffentlicht in:Nature neuroscience 2021-04, Vol.24 (4), p.595-610
Hauptverfasser: Pombo Antunes, Ana Rita, Scheyltjens, Isabelle, Lodi, Francesca, Messiaen, Julie, Antoranz, Asier, Duerinck, Johnny, Kancheva, Daliya, Martens, Liesbet, De Vlaminck, Karen, Van Hove, Hannah, Kjølner Hansen, Signe Schmidt, Bosisio, Francesca Maria, Van der Borght, Koen, De Vleeschouwer, Steven, Sciot, Raf, Bouwens, Luc, Verfaillie, Michiel, Vandamme, Niels, Vandenbroucke, Roosmarijn E., De Wever, Olivier, Saeys, Yvan, Guilliams, Martin, Gysemans, Conny, Neyns, Bart, De Smet, Frederik, Lambrechts, Diether, Van Ginderachter, Jo A., Movahedi, Kiavash
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Sprache:eng
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