The subfornical organ drives hypertension in polycystic kidney disease via the hypothalamic paraventricular nucleus

Abstract Aims Hypertension is a prevalent yet poorly understood feature of polycystic kidney disease. Previously, we demonstrated that increased glutamatergic neurotransmission within the hypothalamic paraventricular nucleus produces hypertension in the Lewis Polycystic Kidney (LPK) rat model of pol...

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Veröffentlicht in:	Cardiovascular research 2022-03, Vol.118 (4), p.1138-1149
Hauptverfasser:	Underwood, Conor F, McMullan, Simon, Goodchild, Ann K, Phillips, Jacqueline K, Hildreth, Cara M
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - metabolism Animals Female Humans Hypertension Male Paraventricular Hypothalamic Nucleus - metabolism Polycystic Kidney Diseases - metabolism Rats Rats, Inbred Lew Receptors, Ionotropic Glutamate - metabolism Subfornical Organ - metabolism
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