Highly cross-linked arabinoxylans microspheres as a microbiota-activated carrier for colon-specific insulin delivery
[Display omitted] In vivo evaluation of arabinoxylans (AX) microspheres showed to protect insulin from degradation in the upper gastrointestinal tract and carrier insulin to colon. Insulin-loaded AX microspheres (50 UI/kg) decreased blood glucose level by 39% in diabetic rats with a maximum effect a...
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| Veröffentlicht in: | European journal of pharmaceutics and biopharmaceutics 2021-06, Vol.163, p.16-22 |
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| container_title | European journal of pharmaceutics and biopharmaceutics |
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| creator | Morales-Burgos, A.M. Carvajal-Millan, E. Sotelo-Cruz, N. Rascón-Chu, A. Lizardi-Mendoza, J. López-Franco, Y.L. Martínez-Porchas, Marcel Canett-Romero, R. |
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In vivo evaluation of arabinoxylans (AX) microspheres showed to protect insulin from degradation in the upper gastrointestinal tract and carrier insulin to colon. Insulin-loaded AX microspheres (50 UI/kg) decreased blood glucose level by 39% in diabetic rats with a maximum effect at 18 h post-administration, indicating that insulin remains bioactive. The continuous administration (4 days) of insulin-loaded AX microspheres improved the polyuria and increased the production of short-chain fatty acids, as well as Bifidobacterium and Bacteroides in diabetic rats compared to untreated diabetic rats. AX microspheres are a potential microbiota-activated carrier for colon-specific drug delivery and could be useful as a complementary treatment for diabetes. |
| doi_str_mv | 10.1016/j.ejpb.2021.02.014 |
| format | Article |
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In vivo evaluation of arabinoxylans (AX) microspheres showed to protect insulin from degradation in the upper gastrointestinal tract and carrier insulin to colon. Insulin-loaded AX microspheres (50 UI/kg) decreased blood glucose level by 39% in diabetic rats with a maximum effect at 18 h post-administration, indicating that insulin remains bioactive. The continuous administration (4 days) of insulin-loaded AX microspheres improved the polyuria and increased the production of short-chain fatty acids, as well as Bifidobacterium and Bacteroides in diabetic rats compared to untreated diabetic rats. AX microspheres are a potential microbiota-activated carrier for colon-specific drug delivery and could be useful as a complementary treatment for diabetes.</description><identifier>ISSN: 0939-6411</identifier><identifier>EISSN: 1873-3441</identifier><identifier>DOI: 10.1016/j.ejpb.2021.02.014</identifier><identifier>PMID: 33774161</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Arabinoxylans ; Colon-targeted ; Drug-delivery ; Insulin carrier ; Microspheres</subject><ispartof>European journal of pharmaceutics and biopharmaceutics, 2021-06, Vol.163, p.16-22</ispartof><rights>2021 Elsevier B.V.</rights><rights>Copyright © 2021 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-80b68f3a53a99fe2bd3cd3d64df21b12053e8b6089ac24c0c37ea86c8eb5fc0e3</citedby><cites>FETCH-LOGICAL-c356t-80b68f3a53a99fe2bd3cd3d64df21b12053e8b6089ac24c0c37ea86c8eb5fc0e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0939641121000758$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33774161$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morales-Burgos, A.M.</creatorcontrib><creatorcontrib>Carvajal-Millan, E.</creatorcontrib><creatorcontrib>Sotelo-Cruz, N.</creatorcontrib><creatorcontrib>Rascón-Chu, A.</creatorcontrib><creatorcontrib>Lizardi-Mendoza, J.</creatorcontrib><creatorcontrib>López-Franco, Y.L.</creatorcontrib><creatorcontrib>Martínez-Porchas, Marcel</creatorcontrib><creatorcontrib>Canett-Romero, R.</creatorcontrib><title>Highly cross-linked arabinoxylans microspheres as a microbiota-activated carrier for colon-specific insulin delivery</title><title>European journal of pharmaceutics and biopharmaceutics</title><addtitle>Eur J Pharm Biopharm</addtitle><description>[Display omitted]
In vivo evaluation of arabinoxylans (AX) microspheres showed to protect insulin from degradation in the upper gastrointestinal tract and carrier insulin to colon. Insulin-loaded AX microspheres (50 UI/kg) decreased blood glucose level by 39% in diabetic rats with a maximum effect at 18 h post-administration, indicating that insulin remains bioactive. The continuous administration (4 days) of insulin-loaded AX microspheres improved the polyuria and increased the production of short-chain fatty acids, as well as Bifidobacterium and Bacteroides in diabetic rats compared to untreated diabetic rats. AX microspheres are a potential microbiota-activated carrier for colon-specific drug delivery and could be useful as a complementary treatment for diabetes.</description><subject>Arabinoxylans</subject><subject>Colon-targeted</subject><subject>Drug-delivery</subject><subject>Insulin carrier</subject><subject>Microspheres</subject><issn>0939-6411</issn><issn>1873-3441</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kEFv1DAQhS0EokvLH-CAcuSSMLYTx5G4oKqlSJW40LNljyfUSzYOdnbF_vt62cIRaaSRZt570vsYe8eh4cDVx21D28U1AgRvQDTA2xdsw3Uva9m2_CXbwCCHWrWcX7A3OW8BoO07_ZpdSNn3LVd8w9a78ONxOlaYYs71FOaf5CubrAtz_H2c7JyrXTg9l0dKlCtb5nxxIa62triGg12LCW1KgVI1xlRhnOJc54UwjAGrMOd9ia48TeFA6XjFXo12yvT2eV-yh9ub79d39f23L1-vP9_XKDu11hqc0qO0nbTDMJJwXqKXXrV-FNxxAZ0k7RTowaJoEVD2ZLVCTa4bEUhesg_n3CXFX3vKq9mFjDSVWhT32YgOVMcLPl2k4iz9AyLRaJYUdjYdDQdzom225kTbnGgbEKbQLqb3z_l7tyP_z_IXbxF8OguotDwUOiZjoBnJh0S4Gh_D__KfAILjk9w</recordid><startdate>202106</startdate><enddate>202106</enddate><creator>Morales-Burgos, A.M.</creator><creator>Carvajal-Millan, E.</creator><creator>Sotelo-Cruz, N.</creator><creator>Rascón-Chu, A.</creator><creator>Lizardi-Mendoza, J.</creator><creator>López-Franco, Y.L.</creator><creator>Martínez-Porchas, Marcel</creator><creator>Canett-Romero, R.</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202106</creationdate><title>Highly cross-linked arabinoxylans microspheres as a microbiota-activated carrier for colon-specific insulin delivery</title><author>Morales-Burgos, A.M. ; Carvajal-Millan, E. ; Sotelo-Cruz, N. ; Rascón-Chu, A. ; Lizardi-Mendoza, J. ; López-Franco, Y.L. ; Martínez-Porchas, Marcel ; Canett-Romero, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-80b68f3a53a99fe2bd3cd3d64df21b12053e8b6089ac24c0c37ea86c8eb5fc0e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Arabinoxylans</topic><topic>Colon-targeted</topic><topic>Drug-delivery</topic><topic>Insulin carrier</topic><topic>Microspheres</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morales-Burgos, A.M.</creatorcontrib><creatorcontrib>Carvajal-Millan, E.</creatorcontrib><creatorcontrib>Sotelo-Cruz, N.</creatorcontrib><creatorcontrib>Rascón-Chu, A.</creatorcontrib><creatorcontrib>Lizardi-Mendoza, J.</creatorcontrib><creatorcontrib>López-Franco, Y.L.</creatorcontrib><creatorcontrib>Martínez-Porchas, Marcel</creatorcontrib><creatorcontrib>Canett-Romero, R.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmaceutics and biopharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morales-Burgos, A.M.</au><au>Carvajal-Millan, E.</au><au>Sotelo-Cruz, N.</au><au>Rascón-Chu, A.</au><au>Lizardi-Mendoza, J.</au><au>López-Franco, Y.L.</au><au>Martínez-Porchas, Marcel</au><au>Canett-Romero, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Highly cross-linked arabinoxylans microspheres as a microbiota-activated carrier for colon-specific insulin delivery</atitle><jtitle>European journal of pharmaceutics and biopharmaceutics</jtitle><addtitle>Eur J Pharm Biopharm</addtitle><date>2021-06</date><risdate>2021</risdate><volume>163</volume><spage>16</spage><epage>22</epage><pages>16-22</pages><issn>0939-6411</issn><eissn>1873-3441</eissn><abstract>[Display omitted]
In vivo evaluation of arabinoxylans (AX) microspheres showed to protect insulin from degradation in the upper gastrointestinal tract and carrier insulin to colon. Insulin-loaded AX microspheres (50 UI/kg) decreased blood glucose level by 39% in diabetic rats with a maximum effect at 18 h post-administration, indicating that insulin remains bioactive. The continuous administration (4 days) of insulin-loaded AX microspheres improved the polyuria and increased the production of short-chain fatty acids, as well as Bifidobacterium and Bacteroides in diabetic rats compared to untreated diabetic rats. AX microspheres are a potential microbiota-activated carrier for colon-specific drug delivery and could be useful as a complementary treatment for diabetes.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>33774161</pmid><doi>10.1016/j.ejpb.2021.02.014</doi><tpages>7</tpages></addata></record> |
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| ispartof | European journal of pharmaceutics and biopharmaceutics, 2021-06, Vol.163, p.16-22 |
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| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Arabinoxylans Colon-targeted Drug-delivery Insulin carrier Microspheres |
| title | Highly cross-linked arabinoxylans microspheres as a microbiota-activated carrier for colon-specific insulin delivery |
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