Dietary daidzein inhibits hepatitis C virus replication by decreasing microRNA-122 levels
•MicroRNA-122 positively regulates hepatitis C virus replication.•IFN-α is the main antiviral agent of current therapy for hepatitis C.•Daidzein inhibits hepatitis C virus replication by decreasing microRNA-122 levels.•Daidzein enhances the antiviral effect of IFN-α on hepatitis C virus therapy. Mic...
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Veröffentlicht in: | Virus research 2021-06, Vol.298, p.198404-198404, Article 198404 |
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creator | He, Yujiao Huang, Maolin Tang, Chunyan Yue, Yan Liu, Xiao Zheng, Zhebin Dong, Hongbo Liu, Deming |
description | •MicroRNA-122 positively regulates hepatitis C virus replication.•IFN-α is the main antiviral agent of current therapy for hepatitis C.•Daidzein inhibits hepatitis C virus replication by decreasing microRNA-122 levels.•Daidzein enhances the antiviral effect of IFN-α on hepatitis C virus therapy.
MicroRNAs are emerging as critical endogenous regulators of gene function. Aberrant regulation of microRNAs is associated with various human diseases, most importantly cancer. MicroRNA-122 (miR-122), a liver-specific microRNA, has been implicated in the control of hepatitis C virus (HCV) RNA replication and its response to interferon (IFN) in human hepatoma cells. Here, we report that daidzein, a naturally occurring plant isoflavone, inhibits HCV replication and enhances the antiviral effect of IFN-α on HCV therapy by decreasing microRNA-122 levels in vitro without significantly affecting cell growth. Moreover, daidzein was found to inhibit the expression of miR-122 and miR-21 by down-regulating the expression of TRBP, indicating that daidzein is possibly a general inhibitor of the miRNA pathway. Thus, daidzein provides new insights for drug discovery and HCV prevention. |
doi_str_mv | 10.1016/j.virusres.2021.198404 |
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MicroRNAs are emerging as critical endogenous regulators of gene function. Aberrant regulation of microRNAs is associated with various human diseases, most importantly cancer. MicroRNA-122 (miR-122), a liver-specific microRNA, has been implicated in the control of hepatitis C virus (HCV) RNA replication and its response to interferon (IFN) in human hepatoma cells. Here, we report that daidzein, a naturally occurring plant isoflavone, inhibits HCV replication and enhances the antiviral effect of IFN-α on HCV therapy by decreasing microRNA-122 levels in vitro without significantly affecting cell growth. Moreover, daidzein was found to inhibit the expression of miR-122 and miR-21 by down-regulating the expression of TRBP, indicating that daidzein is possibly a general inhibitor of the miRNA pathway. Thus, daidzein provides new insights for drug discovery and HCV prevention.</description><identifier>ISSN: 0168-1702</identifier><identifier>EISSN: 1872-7492</identifier><identifier>DOI: 10.1016/j.virusres.2021.198404</identifier><identifier>PMID: 33775754</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Antiviral Agents - metabolism ; Antiviral Agents - pharmacology ; Daidzein ; Hepacivirus - physiology ; Hepatitis C - genetics ; Hepatitis C virus (HCV) ; Humans ; IFN-α ; Interferon-alpha - metabolism ; Isoflavones - metabolism ; Isoflavones - pharmacology ; MicroRNA ; MicroRNAs - genetics ; MicroRNAs - metabolism ; TRBP ; Virus Replication</subject><ispartof>Virus research, 2021-06, Vol.298, p.198404-198404, Article 198404</ispartof><rights>2021 Elsevier B.V.</rights><rights>Copyright © 2021 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-c0388d5fd78f84d843e20ae3e8d71c5a7f03d167736c6bbbaba1f10cc2f462893</citedby><cites>FETCH-LOGICAL-c434t-c0388d5fd78f84d843e20ae3e8d71c5a7f03d167736c6bbbaba1f10cc2f462893</cites><orcidid>0000-0001-6885-6284</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0168170221001118$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33775754$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>He, Yujiao</creatorcontrib><creatorcontrib>Huang, Maolin</creatorcontrib><creatorcontrib>Tang, Chunyan</creatorcontrib><creatorcontrib>Yue, Yan</creatorcontrib><creatorcontrib>Liu, Xiao</creatorcontrib><creatorcontrib>Zheng, Zhebin</creatorcontrib><creatorcontrib>Dong, Hongbo</creatorcontrib><creatorcontrib>Liu, Deming</creatorcontrib><title>Dietary daidzein inhibits hepatitis C virus replication by decreasing microRNA-122 levels</title><title>Virus research</title><addtitle>Virus Res</addtitle><description>•MicroRNA-122 positively regulates hepatitis C virus replication.•IFN-α is the main antiviral agent of current therapy for hepatitis C.•Daidzein inhibits hepatitis C virus replication by decreasing microRNA-122 levels.•Daidzein enhances the antiviral effect of IFN-α on hepatitis C virus therapy.
MicroRNAs are emerging as critical endogenous regulators of gene function. Aberrant regulation of microRNAs is associated with various human diseases, most importantly cancer. MicroRNA-122 (miR-122), a liver-specific microRNA, has been implicated in the control of hepatitis C virus (HCV) RNA replication and its response to interferon (IFN) in human hepatoma cells. Here, we report that daidzein, a naturally occurring plant isoflavone, inhibits HCV replication and enhances the antiviral effect of IFN-α on HCV therapy by decreasing microRNA-122 levels in vitro without significantly affecting cell growth. Moreover, daidzein was found to inhibit the expression of miR-122 and miR-21 by down-regulating the expression of TRBP, indicating that daidzein is possibly a general inhibitor of the miRNA pathway. Thus, daidzein provides new insights for drug discovery and HCV prevention.</description><subject>Antiviral Agents - metabolism</subject><subject>Antiviral Agents - pharmacology</subject><subject>Daidzein</subject><subject>Hepacivirus - physiology</subject><subject>Hepatitis C - genetics</subject><subject>Hepatitis C virus (HCV)</subject><subject>Humans</subject><subject>IFN-α</subject><subject>Interferon-alpha - metabolism</subject><subject>Isoflavones - metabolism</subject><subject>Isoflavones - pharmacology</subject><subject>MicroRNA</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>TRBP</subject><subject>Virus Replication</subject><issn>0168-1702</issn><issn>1872-7492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PGzEQhi0EgjTwF5CPXDb119rOrVHol4RAQu2hJ8trzzYTbXaDvYlEfz2mIVw5jWQ9r9-Zh5Brzmaccf15Pdtj2uUEeSaY4DM-t4qpEzLh1ojKqLk4JZMC2oobJi7Ip5zXjDEtjT4nF1IaU5taTcifW4TRp2caPcZ_gD3FfoUNjpmuYOtHHDHTJf1fRhNsOwzlcehpUyIQEviM_V-6wZCGx_tFxYWgHeyhy5fkrPVdhqu3OSW_v339tfxR3T18_7lc3FVBSTVWgUlrY91GY1urolUSBPMgwUbDQ-1Ny2Tk2hipg26axjeet5yFIFqlhZ3LKbk5_LtNw9MO8ug2mAN0ne9h2GUnaqZrVhujCqoPaFk2F3et2ybclOsdZ-5Vq1u7o1b3qtUdtJbg9VvHrtlAfI8dPRbgywEoh8MeIbkcEPoAEROE0cUBP-p4AQGXjVo</recordid><startdate>202106</startdate><enddate>202106</enddate><creator>He, Yujiao</creator><creator>Huang, Maolin</creator><creator>Tang, Chunyan</creator><creator>Yue, Yan</creator><creator>Liu, Xiao</creator><creator>Zheng, Zhebin</creator><creator>Dong, Hongbo</creator><creator>Liu, Deming</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6885-6284</orcidid></search><sort><creationdate>202106</creationdate><title>Dietary daidzein inhibits hepatitis C virus replication by decreasing microRNA-122 levels</title><author>He, Yujiao ; Huang, Maolin ; Tang, Chunyan ; Yue, Yan ; Liu, Xiao ; Zheng, Zhebin ; Dong, Hongbo ; Liu, Deming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-c0388d5fd78f84d843e20ae3e8d71c5a7f03d167736c6bbbaba1f10cc2f462893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Antiviral Agents - metabolism</topic><topic>Antiviral Agents - pharmacology</topic><topic>Daidzein</topic><topic>Hepacivirus - physiology</topic><topic>Hepatitis C - genetics</topic><topic>Hepatitis C virus (HCV)</topic><topic>Humans</topic><topic>IFN-α</topic><topic>Interferon-alpha - metabolism</topic><topic>Isoflavones - metabolism</topic><topic>Isoflavones - pharmacology</topic><topic>MicroRNA</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - metabolism</topic><topic>TRBP</topic><topic>Virus Replication</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>He, Yujiao</creatorcontrib><creatorcontrib>Huang, Maolin</creatorcontrib><creatorcontrib>Tang, Chunyan</creatorcontrib><creatorcontrib>Yue, Yan</creatorcontrib><creatorcontrib>Liu, Xiao</creatorcontrib><creatorcontrib>Zheng, Zhebin</creatorcontrib><creatorcontrib>Dong, Hongbo</creatorcontrib><creatorcontrib>Liu, Deming</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Virus research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>He, Yujiao</au><au>Huang, Maolin</au><au>Tang, Chunyan</au><au>Yue, Yan</au><au>Liu, Xiao</au><au>Zheng, Zhebin</au><au>Dong, Hongbo</au><au>Liu, Deming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary daidzein inhibits hepatitis C virus replication by decreasing microRNA-122 levels</atitle><jtitle>Virus research</jtitle><addtitle>Virus Res</addtitle><date>2021-06</date><risdate>2021</risdate><volume>298</volume><spage>198404</spage><epage>198404</epage><pages>198404-198404</pages><artnum>198404</artnum><issn>0168-1702</issn><eissn>1872-7492</eissn><abstract>•MicroRNA-122 positively regulates hepatitis C virus replication.•IFN-α is the main antiviral agent of current therapy for hepatitis C.•Daidzein inhibits hepatitis C virus replication by decreasing microRNA-122 levels.•Daidzein enhances the antiviral effect of IFN-α on hepatitis C virus therapy.
MicroRNAs are emerging as critical endogenous regulators of gene function. Aberrant regulation of microRNAs is associated with various human diseases, most importantly cancer. MicroRNA-122 (miR-122), a liver-specific microRNA, has been implicated in the control of hepatitis C virus (HCV) RNA replication and its response to interferon (IFN) in human hepatoma cells. Here, we report that daidzein, a naturally occurring plant isoflavone, inhibits HCV replication and enhances the antiviral effect of IFN-α on HCV therapy by decreasing microRNA-122 levels in vitro without significantly affecting cell growth. Moreover, daidzein was found to inhibit the expression of miR-122 and miR-21 by down-regulating the expression of TRBP, indicating that daidzein is possibly a general inhibitor of the miRNA pathway. Thus, daidzein provides new insights for drug discovery and HCV prevention.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>33775754</pmid><doi>10.1016/j.virusres.2021.198404</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-6885-6284</orcidid></addata></record> |
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subjects | Antiviral Agents - metabolism Antiviral Agents - pharmacology Daidzein Hepacivirus - physiology Hepatitis C - genetics Hepatitis C virus (HCV) Humans IFN-α Interferon-alpha - metabolism Isoflavones - metabolism Isoflavones - pharmacology MicroRNA MicroRNAs - genetics MicroRNAs - metabolism TRBP Virus Replication |
title | Dietary daidzein inhibits hepatitis C virus replication by decreasing microRNA-122 levels |
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