Activation of anti-oxidant Keap1/Nrf2 pathway modulates efficacy of dihydroartemisinin-based monotherapy and combinatory therapy with ionizing radiation

The efficacy of radiotherapy depends not only on DNA damage but also on ROS production, both induced by ionizing radiation. Massive ROS production can induce cell death or activate protective pathways such as Keap1/Nrf2 pathway, which regulates intracellular cysteine availability through upregulatio...

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Veröffentlicht in:	Free radical biology & medicine 2021-05, Vol.168, p.44-54
Hauptverfasser:	Bader, Sina, Wilmers, Julia, Pelzer, Martin, Jendrossek, Verena, Rudner, Justine
Format:	Artikel
Sprache:	eng
Schlagworte:	Colorectal cancer Glutathione Lung cancer Oxidative damage Radiotherapy Reactive oxygen species
Online-Zugang:	Volltext
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