Differential functional connectivity of insular subdivisions in de novo Parkinson’s disease with mild cognitive impairment
The insula, consisting of functionally diverse subdivisions, plays a significant role in Parkinson’s disease (PD)-related cognitive disorders. However, the functional connectivity (FC) patterns of insular subdivisions in PD remain unclear. Our aim is to investigate the changes in FC patterns of insu...
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| creator | Pan, Chenxi Ren, Jingru Li, Lanting Li, Yuqian Xu, Jianxia Xue, Chen Hu, Guanjie Yu, Miao Chen, Yong Zhang, Li Zhang, Wenbing Hu, Xiao Sun, Yu Liu, Weiguo Chen, Jiu |
| description | The insula, consisting of functionally diverse subdivisions, plays a significant role in Parkinson’s disease (PD)-related cognitive disorders. However, the functional connectivity (FC) patterns of insular subdivisions in PD remain unclear. Our aim is to investigate the changes in FC patterns of insular subdivisions and their relationships with cognitive domains. Three groups of participants were recruited in this study, including PD patients with mild cognitive impairment (PD-MCI, n = 25), PD patients with normal cognition (PD-NC, n = 13), and healthy controls (HCs, n = 17). Resting-state functional magnetic resonance imaging (rs-fMRI) was used to investigate the FC in insular subdivisions of the three groups. Moreover, all participants underwent a neuropsychological battery to assess cognition so that the relationship between altered FC and cognitive performance could be elucidated. Compared with the PD-NC group, the PD-MCI group exhibited increased FC between the left dorsal anterior insular (dAI) and the right superior parietal gyrus (SPG), and altered FC was negatively correlated with memory and executive function. Compared with the HC group, the PD-MCI group showed significantly increased FC between the right dAI and the right median cingulate and paracingulate gyri (DCG), and altered FC was positively related to attention/working memory, visuospatial function, and language. Our findings highlighted the different abnormal FC patterns of insular subdivisions in PD patients with different cognitive abilities. Furthermore, dysfunction of the dAI may partly contribute to the decline in executive function and memory in early drug-naïve PD patients. |
| doi_str_mv | 10.1007/s11682-021-00471-2 |
| format | Article |
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However, the functional connectivity (FC) patterns of insular subdivisions in PD remain unclear. Our aim is to investigate the changes in FC patterns of insular subdivisions and their relationships with cognitive domains. Three groups of participants were recruited in this study, including PD patients with mild cognitive impairment (PD-MCI, n = 25), PD patients with normal cognition (PD-NC, n = 13), and healthy controls (HCs, n = 17). Resting-state functional magnetic resonance imaging (rs-fMRI) was used to investigate the FC in insular subdivisions of the three groups. Moreover, all participants underwent a neuropsychological battery to assess cognition so that the relationship between altered FC and cognitive performance could be elucidated. Compared with the PD-NC group, the PD-MCI group exhibited increased FC between the left dorsal anterior insular (dAI) and the right superior parietal gyrus (SPG), and altered FC was negatively correlated with memory and executive function. Compared with the HC group, the PD-MCI group showed significantly increased FC between the right dAI and the right median cingulate and paracingulate gyri (DCG), and altered FC was positively related to attention/working memory, visuospatial function, and language. Our findings highlighted the different abnormal FC patterns of insular subdivisions in PD patients with different cognitive abilities. Furthermore, dysfunction of the dAI may partly contribute to the decline in executive function and memory in early drug-naïve PD patients.</description><identifier>ISSN: 1931-7557</identifier><identifier>EISSN: 1931-7565</identifier><identifier>DOI: 10.1007/s11682-021-00471-2</identifier><identifier>PMID: 33770371</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; Cognition ; Cognition & reasoning ; Cognition Disorders ; Cognitive ability ; Cognitive Dysfunction - diagnostic imaging ; Executive function ; Functional magnetic resonance imaging ; Humans ; Impairment ; Magnetic Resonance Imaging ; Memory ; Memory, Short-Term ; Movement disorders ; Neural networks ; Neurodegenerative diseases ; Neuropsychology ; Neuroradiology ; Neurosciences ; Original Research ; Parkinson Disease - diagnostic imaging ; Parkinson's disease ; Psychiatry ; Short term memory ; Spatial memory ; Subdivisions</subject><ispartof>Brain imaging and behavior, 2022-02, Vol.16 (1), p.1-10</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-db29fae68c601156840dfa84513e21129fd9b18dab6a2a259d6581ed5ebbb62a3</citedby><cites>FETCH-LOGICAL-c419t-db29fae68c601156840dfa84513e21129fd9b18dab6a2a259d6581ed5ebbb62a3</cites><orcidid>0000-0001-8185-8575</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11682-021-00471-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11682-021-00471-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33770371$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pan, Chenxi</creatorcontrib><creatorcontrib>Ren, Jingru</creatorcontrib><creatorcontrib>Li, Lanting</creatorcontrib><creatorcontrib>Li, Yuqian</creatorcontrib><creatorcontrib>Xu, Jianxia</creatorcontrib><creatorcontrib>Xue, Chen</creatorcontrib><creatorcontrib>Hu, Guanjie</creatorcontrib><creatorcontrib>Yu, Miao</creatorcontrib><creatorcontrib>Chen, Yong</creatorcontrib><creatorcontrib>Zhang, Li</creatorcontrib><creatorcontrib>Zhang, Wenbing</creatorcontrib><creatorcontrib>Hu, Xiao</creatorcontrib><creatorcontrib>Sun, Yu</creatorcontrib><creatorcontrib>Liu, Weiguo</creatorcontrib><creatorcontrib>Chen, Jiu</creatorcontrib><title>Differential functional connectivity of insular subdivisions in de novo Parkinson’s disease with mild cognitive impairment</title><title>Brain imaging and behavior</title><addtitle>Brain Imaging and Behavior</addtitle><addtitle>Brain Imaging Behav</addtitle><description>The insula, consisting of functionally diverse subdivisions, plays a significant role in Parkinson’s disease (PD)-related cognitive disorders. However, the functional connectivity (FC) patterns of insular subdivisions in PD remain unclear. Our aim is to investigate the changes in FC patterns of insular subdivisions and their relationships with cognitive domains. Three groups of participants were recruited in this study, including PD patients with mild cognitive impairment (PD-MCI, n = 25), PD patients with normal cognition (PD-NC, n = 13), and healthy controls (HCs, n = 17). Resting-state functional magnetic resonance imaging (rs-fMRI) was used to investigate the FC in insular subdivisions of the three groups. Moreover, all participants underwent a neuropsychological battery to assess cognition so that the relationship between altered FC and cognitive performance could be elucidated. Compared with the PD-NC group, the PD-MCI group exhibited increased FC between the left dorsal anterior insular (dAI) and the right superior parietal gyrus (SPG), and altered FC was negatively correlated with memory and executive function. Compared with the HC group, the PD-MCI group showed significantly increased FC between the right dAI and the right median cingulate and paracingulate gyri (DCG), and altered FC was positively related to attention/working memory, visuospatial function, and language. Our findings highlighted the different abnormal FC patterns of insular subdivisions in PD patients with different cognitive abilities. Furthermore, dysfunction of the dAI may partly contribute to the decline in executive function and memory in early drug-naïve PD patients.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cognition</subject><subject>Cognition & reasoning</subject><subject>Cognition Disorders</subject><subject>Cognitive ability</subject><subject>Cognitive Dysfunction - diagnostic imaging</subject><subject>Executive function</subject><subject>Functional magnetic resonance imaging</subject><subject>Humans</subject><subject>Impairment</subject><subject>Magnetic Resonance Imaging</subject><subject>Memory</subject><subject>Memory, Short-Term</subject><subject>Movement disorders</subject><subject>Neural networks</subject><subject>Neurodegenerative diseases</subject><subject>Neuropsychology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Original Research</subject><subject>Parkinson Disease - diagnostic imaging</subject><subject>Parkinson's disease</subject><subject>Psychiatry</subject><subject>Short term memory</subject><subject>Spatial memory</subject><subject>Subdivisions</subject><issn>1931-7557</issn><issn>1931-7565</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kc1u1TAQhS0EoqXwAl1UltiwCXic2HGWqC0FqRIsYG058aR1m9i3dtKqEgteg9frkzBwSyuxYDV_35yR5jC2D-ItCNG-KwDayEpIqIRoWqjkE7YLXQ1Vq7R6-pCrdoe9KOVCCNWYDp6znbpuW1G3sMu-H4VxxIxxCW7i4xqHJaRI6ZBiRCquw3LL08hDLOvkMi9r76lZiCrU5B55TNeJf3H5kpgU7378LNyHgq4gvwnLOZ_D5EnvLAaSQx7mjQt5ppMv2bPRTQVf3cc99u3D8dfDj9Xp55NPh-9Pq6GBbql8L7vRoTaDFgBKm0b40ZlGQY0SgIa-68F412snnVSd18oAeoV932vp6j32Zqu7yelqxbLYOZQBp8lFTGuxUgktO5CmJfT1P-hFWjM9hCgtdWO0AUGU3FJDTqVkHO0mh9nlWwvC_vbGbr2x5I39442VtHRwL732M_qHlb9mEFBvgUKjeIb58fZ_ZH8BvdqdOg</recordid><startdate>20220201</startdate><enddate>20220201</enddate><creator>Pan, Chenxi</creator><creator>Ren, Jingru</creator><creator>Li, Lanting</creator><creator>Li, Yuqian</creator><creator>Xu, Jianxia</creator><creator>Xue, Chen</creator><creator>Hu, Guanjie</creator><creator>Yu, Miao</creator><creator>Chen, Yong</creator><creator>Zhang, Li</creator><creator>Zhang, Wenbing</creator><creator>Hu, Xiao</creator><creator>Sun, Yu</creator><creator>Liu, Weiguo</creator><creator>Chen, Jiu</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8185-8575</orcidid></search><sort><creationdate>20220201</creationdate><title>Differential functional connectivity of insular subdivisions in de novo Parkinson’s disease with mild cognitive impairment</title><author>Pan, Chenxi ; Ren, Jingru ; Li, Lanting ; Li, Yuqian ; Xu, Jianxia ; Xue, Chen ; Hu, Guanjie ; Yu, Miao ; Chen, Yong ; Zhang, Li ; Zhang, Wenbing ; Hu, Xiao ; Sun, Yu ; Liu, Weiguo ; Chen, Jiu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-db29fae68c601156840dfa84513e21129fd9b18dab6a2a259d6581ed5ebbb62a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cognition</topic><topic>Cognition & reasoning</topic><topic>Cognition Disorders</topic><topic>Cognitive ability</topic><topic>Cognitive Dysfunction - diagnostic imaging</topic><topic>Executive function</topic><topic>Functional magnetic resonance imaging</topic><topic>Humans</topic><topic>Impairment</topic><topic>Magnetic Resonance Imaging</topic><topic>Memory</topic><topic>Memory, Short-Term</topic><topic>Movement disorders</topic><topic>Neural networks</topic><topic>Neurodegenerative diseases</topic><topic>Neuropsychology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Original Research</topic><topic>Parkinson Disease - diagnostic imaging</topic><topic>Parkinson's disease</topic><topic>Psychiatry</topic><topic>Short term memory</topic><topic>Spatial memory</topic><topic>Subdivisions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pan, Chenxi</creatorcontrib><creatorcontrib>Ren, Jingru</creatorcontrib><creatorcontrib>Li, Lanting</creatorcontrib><creatorcontrib>Li, Yuqian</creatorcontrib><creatorcontrib>Xu, Jianxia</creatorcontrib><creatorcontrib>Xue, Chen</creatorcontrib><creatorcontrib>Hu, Guanjie</creatorcontrib><creatorcontrib>Yu, Miao</creatorcontrib><creatorcontrib>Chen, Yong</creatorcontrib><creatorcontrib>Zhang, Li</creatorcontrib><creatorcontrib>Zhang, Wenbing</creatorcontrib><creatorcontrib>Hu, Xiao</creatorcontrib><creatorcontrib>Sun, Yu</creatorcontrib><creatorcontrib>Liu, Weiguo</creatorcontrib><creatorcontrib>Chen, Jiu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Brain imaging and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pan, Chenxi</au><au>Ren, Jingru</au><au>Li, Lanting</au><au>Li, Yuqian</au><au>Xu, Jianxia</au><au>Xue, Chen</au><au>Hu, Guanjie</au><au>Yu, Miao</au><au>Chen, Yong</au><au>Zhang, Li</au><au>Zhang, Wenbing</au><au>Hu, Xiao</au><au>Sun, Yu</au><au>Liu, Weiguo</au><au>Chen, Jiu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential functional connectivity of insular subdivisions in de novo Parkinson’s disease with mild cognitive impairment</atitle><jtitle>Brain imaging and behavior</jtitle><stitle>Brain Imaging and Behavior</stitle><addtitle>Brain Imaging Behav</addtitle><date>2022-02-01</date><risdate>2022</risdate><volume>16</volume><issue>1</issue><spage>1</spage><epage>10</epage><pages>1-10</pages><issn>1931-7557</issn><eissn>1931-7565</eissn><abstract>The insula, consisting of functionally diverse subdivisions, plays a significant role in Parkinson’s disease (PD)-related cognitive disorders. However, the functional connectivity (FC) patterns of insular subdivisions in PD remain unclear. Our aim is to investigate the changes in FC patterns of insular subdivisions and their relationships with cognitive domains. Three groups of participants were recruited in this study, including PD patients with mild cognitive impairment (PD-MCI, n = 25), PD patients with normal cognition (PD-NC, n = 13), and healthy controls (HCs, n = 17). Resting-state functional magnetic resonance imaging (rs-fMRI) was used to investigate the FC in insular subdivisions of the three groups. Moreover, all participants underwent a neuropsychological battery to assess cognition so that the relationship between altered FC and cognitive performance could be elucidated. Compared with the PD-NC group, the PD-MCI group exhibited increased FC between the left dorsal anterior insular (dAI) and the right superior parietal gyrus (SPG), and altered FC was negatively correlated with memory and executive function. Compared with the HC group, the PD-MCI group showed significantly increased FC between the right dAI and the right median cingulate and paracingulate gyri (DCG), and altered FC was positively related to attention/working memory, visuospatial function, and language. Our findings highlighted the different abnormal FC patterns of insular subdivisions in PD patients with different cognitive abilities. Furthermore, dysfunction of the dAI may partly contribute to the decline in executive function and memory in early drug-naïve PD patients.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>33770371</pmid><doi>10.1007/s11682-021-00471-2</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-8185-8575</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Biomedical and Life Sciences Biomedicine Cognition Cognition & reasoning Cognition Disorders Cognitive ability Cognitive Dysfunction - diagnostic imaging Executive function Functional magnetic resonance imaging Humans Impairment Magnetic Resonance Imaging Memory Memory, Short-Term Movement disorders Neural networks Neurodegenerative diseases Neuropsychology Neuroradiology Neurosciences Original Research Parkinson Disease - diagnostic imaging Parkinson's disease Psychiatry Short term memory Spatial memory Subdivisions |
| title | Differential functional connectivity of insular subdivisions in de novo Parkinson’s disease with mild cognitive impairment |
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