TRIF-mediated antiviral signaling is differentially regulated by TRAF2 and TRAF6 in black carp

TRIF is an antiviral adaptor downstream of Toll-like receptors, the roles of teleost TRIF and their regulation remain largely unknown. In this study, a TRIF homologue (bcTRIF) of black carp (Mylopharyngodon piceus) has been cloned, and the transcription of bcTRIF in vivo and ex vivo increased in res...

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Veröffentlicht in:	Developmental and comparative immunology 2021-08, Vol.121, p.104073-104073, Article 104073
Hauptverfasser:	Peng, Fei, Jin, Saisai, Chen, Zhaoyuan, Chang, Haiyan, Xiao, Jun, Li, Jianzhong, Zou, Jun, Feng, Hao
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Vesicular Transport - genetics Adaptor Proteins, Vesicular Transport - metabolism Animals Antiviral activity Black carp Carp Carps - genetics Carps - immunology Carps - virology Cloning, Molecular Down-Regulation - immunology Fish Diseases - immunology Fish Diseases - virology Fish Proteins - genetics Fish Proteins - metabolism Homology Immunoprecipitation Interferon Receptors, Immunologic - genetics Receptors, Immunologic - metabolism Signaling TNF Receptor-Associated Factor 2 - metabolism TNF Receptor-Associated Factor 6 - metabolism Toll-like receptors TRAF2 TRAF2 protein TRAF6 TRAF6 protein Transcription TRIF Up-Regulation - immunology Viremia Viruses
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