Enantiomeric 4′-truncated 6′-fluoro-3-deazaneplanocin and its 3-bromo derivative: Synthesis and antiviral properties, including Ebola and Marburg

[Display omitted] In seeking to increase the library of fluorine containing adenine-derived carbocyclic nucleoside antiviral candidates, d-like and l-like 6′-fluoro-3-deazaneplanocin and its 3-bromo derivative lacking the 4′-hydroxylmethylene substituent (2/3 and 4/5, respectively) are presented. Th...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2021-06, Vol.41, p.127985-127985, Article 127985
Hauptverfasser:	Haverkamp, Chloe, Liu, Chong, Schneller, Stewart W.
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Deazaneplanocin Ebola Enantiomeric carbocyclic nucleosides Marburg Measles Mitsunobu reaction Norovirus α-Fluorocyclopentenones
Online-Zugang:	Volltext
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