Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis

Mitochondria have an independent genome (mtDNA) and protein synthesis machinery that coordinately activate for mitochondrial generation. Here, we report that the Krebs cycle intermediate fumarate links metabolism to mitobiogenesis through binding to malic enzyme 2 (ME2). Mechanistically, fumarate bi...

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Veröffentlicht in:	Cell metabolism 2021-05, Vol.33 (5), p.1027-1041.e8
Hauptverfasser:	Wang, Yi-Ping, Sharda, Azeem, Xu, Shuang-Nian, van Gastel, Nick, Man, Cheuk Him, Choi, Una, Leong, Wei Zhong, Li, Xi, Scadden, David T.
Format:	Artikel
Sprache:	eng
Schlagworte:	acute myeloid leukemia Animals arginine methylation Cell Line Citric Acid Cycle deoxyuridine 5′-triphosphate nucleotidohydrolase Dimerization DNA, Mitochondrial - metabolism fumarate Fumarates - metabolism Humans Leukemia - pathology Leukemia - veterinary Malate Dehydrogenase - antagonists & inhibitors Malate Dehydrogenase - genetics Malate Dehydrogenase - metabolism malic enzyme 2 Mice Mice, Inbred C57BL Mice, Inbred NOD mitobiogenesis Mitochondria - genetics Mitochondria - metabolism mitochondrial ribosome mitochondrial ribosome protein L45 protein arginine methyltransferase 1 Protein Binding Protein-Arginine N-Methyltransferases - antagonists & inhibitors Protein-Arginine N-Methyltransferases - genetics Protein-Arginine N-Methyltransferases - metabolism Pyrophosphatases - metabolism Ribosomal Proteins - metabolism RNA Interference RNA, Small Interfering - metabolism Thymidine - metabolism
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