Polyploid giant cancer cells, stemness and epithelial-mesenchymal plasticity elicited by human cytomegalovirus

A growing body of evidence is recognizing human cytomegalovirus (HCMV) as a potential oncogenic virus. We hereby provide the first experimental in vitro evidence for HCMV as a reprogramming vector, through the induction of dedifferentiation of mature human mammary epithelial cells (HMECs), generatio...

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Veröffentlicht in:	Oncogene 2021-04, Vol.40 (17), p.3030-3046
Hauptverfasser:	Nehme, Zeina, Pasquereau, Sébastien, Haidar Ahmad, Sandy, Coaquette, Alain, Molimard, Chloé, Monnien, Franck, Algros, Marie-Paule, Adotevi, Olivier, Diab Assaf, Mona, Feugeas, Jean-Paul, Herbein, Georges
Format:	Artikel
Sprache:	eng
Schlagworte:	14/63 631/326 631/67 96/31 Adenocarcinoma Apoptosis Breast cancer Breast Neoplasms - pathology Breast Neoplasms - virology Cell Biology Cell transformation Cell Transformation, Neoplastic Cytomegalovirus Cytomegalovirus - physiology Cytomegalovirus Infections - pathology Cytomegalovirus Infections - virology Cytomegaloviruses Development and progression Embryo cells Epithelial cells Epithelial Cells - metabolism Epithelial Cells - pathology Epithelial Cells - virology Epithelial-Mesenchymal Transition Female Giant Cells - metabolism Giant Cells - pathology Giant Cells - virology Health aspects Human Genetics Humans Internal Medicine Mammary gland Mammary Glands, Human - pathology Mammary Glands, Human - virology Medicine Medicine & Public Health Mesenchyme Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Neoplastic Stem Cells - virology Oncology Phenotypes Plasticity Polyploidy Risk factors Stem cells Tumorigenesis
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